Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2

In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used CYP2E1-enriched human liver microsomes (HLM) obtained by the incorporation of purified CYP2E1. Using a techni...

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Veröffentlicht in:	Biochemical journal 2019-12, Vol.476 (23), p.3661-3685
Hauptverfasser:	Davydova, Nadezhda Y, Dangi, Bikash, Maldonado, Marc A, Vavilov, Nikita E, Zgoda, Victor G, Davydov, Dmitri R
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Membrane - metabolism Cytochrome P-450 CYP1A2 - metabolism Cytochrome P-450 CYP2C19 - metabolism Cytochrome P-450 CYP2E1 - metabolism Dealkylation Escherichia coli - metabolism Female Humans Liver - cytology Male Mass Spectrometry Microsomes, Liver - metabolism NADPH-Ferrihemoprotein Reductase - metabolism Oxazines - metabolism Oxidation-Reduction Spectrometry, Fluorescence Substrate Specificity Tissue Donors
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