Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice

Schwann cell-derived exosomes communicate with dorsal root ganglia (DRG) neurons. The current study investigated the therapeutic effect of exosomes derived from healthy Schwann cells (SC-Exos) on diabetic peripheral neuropathy (DPN). We found that intravenous administration of SC-Exos to type 2 diab...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2020-04, Vol.69 (4), p.749-759
Hauptverfasser:	Wang, Lei, Chopp, Michael, Szalad, Alexandra, Lu, XueRong, Zhang, Yi, Wang, Xinli, Cepparulo, Pasquale, Lu, Mei, Li, Chao, Zhang, Zheng Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - physiopathology Diabetic Neuropathies - physiopathology Dorsal root ganglia Exosomes Exosomes - transplantation Ganglia, Spinal - physiopathology Intravenous administration Male Mice miRNA Myelination Nerve conduction NF-κB protein Peripheral neuropathy Pharmacology and Therapeutics Polymerase chain reaction PTEN protein RhoA protein Schwann cells Schwann Cells - cytology Sciatic nerve Sciatic Nerve - physiopathology Tensin
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