Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform

Overexpression of a gene of interest is a general approach used in both basic research and therapeutic applications. However, the conventional approach involving overexpression of exogenous genes has difficulty achieving complete genome coverage, and is also limited by the cloning capacity of viral...

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Veröffentlicht in:	International journal of molecular sciences 2020-02, Vol.21 (5), p.1574
Hauptverfasser:	Morita, Sumiyo, Horii, Takuro, Kimura, Mika, Hatada, Izuho
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Amino acids Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Cloning vectors Communication CRISPR-Associated Protein 9 - genetics CRISPR-Associated Protein 9 - metabolism CRISPR-Cas Systems Deoxyribonucleic acid DNA Expression vectors Format Gene expression Gene therapy Genes Genetic Engineering - methods Genomes Humans Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular weight Peptides Promoter Regions, Genetic Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism RNA, Guide, CRISPR-Cas Systems - genetics RNA, Guide, CRISPR-Cas Systems - metabolism Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism Tethering Therapeutic applications Tiling Transcription activation Transcription factors Up-Regulation
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