Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress
We aimed to study the effects of an ethyl acetate fraction of (PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg r...
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| Veröffentlicht in: | International journal of molecular sciences 2020-03, Vol.21 (5), p.1836 |
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| creator | Sun, Kaiyue Sun, Yingting Li, Heyang Han, Dongyao Bai, Yuting Zhao, Rong Guo, Zijiao |
| description | We aimed to study the effects of an ethyl acetate fraction of
(PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated
-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders. |
| doi_str_mv | 10.3390/ijms21051836 |
| format | Article |
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(PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated
-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21051836</identifier><identifier>PMID: 32155871</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acetic acid ; Aging ; Aging (artificial) ; D-Galactose ; Diabetes ; Disease ; Ethyl acetate ; Flavonoids ; Galactose ; Galactosidase ; Gallic acid ; Hippocampus ; Histopathology ; Injury prevention ; Liver ; Memory ; Oleanolic acid ; Oxidative stress ; Pattern recognition ; Phenols ; Physalis alkekengi ; Plasma ; Rutin ; Saponins ; Senescence ; Spleen ; β-Galactosidase</subject><ispartof>International journal of molecular sciences, 2020-03, Vol.21 (5), p.1836</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-806ba4cb167aed14b3ad2cd40beed0a84de365fb88bb769b1a93d694e5a7ede43</citedby><cites>FETCH-LOGICAL-c412t-806ba4cb167aed14b3ad2cd40beed0a84de365fb88bb769b1a93d694e5a7ede43</cites><orcidid>0000-0003-3642-6970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084245/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084245/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32155871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Kaiyue</creatorcontrib><creatorcontrib>Sun, Yingting</creatorcontrib><creatorcontrib>Li, Heyang</creatorcontrib><creatorcontrib>Han, Dongyao</creatorcontrib><creatorcontrib>Bai, Yuting</creatorcontrib><creatorcontrib>Zhao, Rong</creatorcontrib><creatorcontrib>Guo, Zijiao</creatorcontrib><title>Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>We aimed to study the effects of an ethyl acetate fraction of
(PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated
-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.</description><subject>Acetic acid</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>D-Galactose</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Ethyl acetate</subject><subject>Flavonoids</subject><subject>Galactose</subject><subject>Galactosidase</subject><subject>Gallic acid</subject><subject>Hippocampus</subject><subject>Histopathology</subject><subject>Injury prevention</subject><subject>Liver</subject><subject>Memory</subject><subject>Oleanolic acid</subject><subject>Oxidative stress</subject><subject>Pattern recognition</subject><subject>Phenols</subject><subject>Physalis alkekengi</subject><subject>Plasma</subject><subject>Rutin</subject><subject>Saponins</subject><subject>Senescence</subject><subject>Spleen</subject><subject>β-Galactosidase</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU1v1DAQhiMEoqVw44wsceFAwF_5uiCtVgtUWlRE4RxN7EnirdcutlOxv4c_iqGlWrh4LM3jd-b1WxTPGX0jREffmt0-ckYr1or6QXHKJOclpXXz8Oh-UjyJcUcpF7zqHhcngrOqaht2WvxcuWTK1YTGTWQzjqgS8SP5PB8iWBMJ2Cu8QjcZsknzwZKVwgQJyRYOGIh3BIguJ7Cgko9Ynju9KNTkk18i5lOjJWkOfpnmXJF8wdxPJr_LQ9Zo7WIhkEt0GBU6hQScJhc_jIZkbpBcpoAxPi0ejWAjPrurZ8W395uv64_l9uLD-Xq1LZVkPJUtrQeQamB1A6iZHARorrSkA6Km0EqNoq7GoW2Hoam7gUEndN1JrKBBjVKcFe9uda-XYY86L5QC2P46mD2EQ-_B9P92nJn7yd_0DW0ll1UWeHUnEPz3BWPq9yb7shYc5g_puWhqLjkVXUZf_ofu_BJctveHolKIlmbq9S2lgo8x4Hi_DKP97_T74_Qz_uLYwD38N27xC1uOrsI</recordid><startdate>20200306</startdate><enddate>20200306</enddate><creator>Sun, Kaiyue</creator><creator>Sun, Yingting</creator><creator>Li, Heyang</creator><creator>Han, Dongyao</creator><creator>Bai, Yuting</creator><creator>Zhao, Rong</creator><creator>Guo, Zijiao</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3642-6970</orcidid></search><sort><creationdate>20200306</creationdate><title>Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress</title><author>Sun, Kaiyue ; Sun, Yingting ; Li, Heyang ; Han, Dongyao ; Bai, Yuting ; Zhao, Rong ; Guo, Zijiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-806ba4cb167aed14b3ad2cd40beed0a84de365fb88bb769b1a93d694e5a7ede43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetic acid</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>D-Galactose</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Ethyl acetate</topic><topic>Flavonoids</topic><topic>Galactose</topic><topic>Galactosidase</topic><topic>Gallic acid</topic><topic>Hippocampus</topic><topic>Histopathology</topic><topic>Injury prevention</topic><topic>Liver</topic><topic>Memory</topic><topic>Oleanolic acid</topic><topic>Oxidative stress</topic><topic>Pattern recognition</topic><topic>Phenols</topic><topic>Physalis alkekengi</topic><topic>Plasma</topic><topic>Rutin</topic><topic>Saponins</topic><topic>Senescence</topic><topic>Spleen</topic><topic>β-Galactosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Kaiyue</creatorcontrib><creatorcontrib>Sun, Yingting</creatorcontrib><creatorcontrib>Li, Heyang</creatorcontrib><creatorcontrib>Han, Dongyao</creatorcontrib><creatorcontrib>Bai, Yuting</creatorcontrib><creatorcontrib>Zhao, Rong</creatorcontrib><creatorcontrib>Guo, Zijiao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Kaiyue</au><au>Sun, Yingting</au><au>Li, Heyang</au><au>Han, Dongyao</au><au>Bai, Yuting</au><au>Zhao, Rong</au><au>Guo, Zijiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-03-06</date><risdate>2020</risdate><volume>21</volume><issue>5</issue><spage>1836</spage><pages>1836-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>We aimed to study the effects of an ethyl acetate fraction of
(PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated
-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Overall, this study showed the potential application of PAE for the prevention or treatment of ageing-associated disorders.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32155871</pmid><doi>10.3390/ijms21051836</doi><orcidid>https://orcid.org/0000-0003-3642-6970</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acetic acid Aging Aging (artificial) D-Galactose Diabetes Disease Ethyl acetate Flavonoids Galactose Galactosidase Gallic acid Hippocampus Histopathology Injury prevention Liver Memory Oleanolic acid Oxidative stress Pattern recognition Phenols Physalis alkekengi Plasma Rutin Saponins Senescence Spleen β-Galactosidase |
| title | Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress |
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