Anticancer effects of epigallocatechin-3-gallate nanoemulsion on lung cancer cells through the activation of AMP-activated protein kinase signaling pathway

Epigallocatechin-3-gallate (EGCG), a green tea–derived polyphenol, exhibits antitumor activities. An EGCG nanoemulsion (nano-EGCG) was prepared to improve the stability and reduce the side effects of EGCG for treatment of human lung cancer cells, and the antitumor effects were studied. The possible...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.5163-5163, Article 5163
Hauptverfasser:	Chen, Bing-Huei, Hsieh, Chia-Hung, Tsai, Su-Yun, Wang, Chian-Yu, Wang, Chi-Chung
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 38/1 631/67/1612/1350 692/4028/67/1612/1350 82/80 AMP AMP-activated protein kinase AMP-Activated Protein Kinases - drug effects AMP-Activated Protein Kinases - metabolism Antitumor activity Catechin - analogs & derivatives Catechin - metabolism Catechin - pharmacology Cell activation Cell Line, Tumor Cell migration Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Colonies Drug Delivery Systems - methods Emulsions Epigallocatechin-3-gallate Gelatinase B Green tea Humanities and Social Sciences Humans Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - pathology MAP Kinase Signaling System - drug effects Matrix metalloproteinase Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Metalloproteinase multidisciplinary Nanoemulsions p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Regulatory proteins Science Science (multidisciplinary) Signal transduction Signal Transduction - drug effects
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