Whole genome analysis identifies the association of TP53 genomic deletions with lower survival in Stage III colorectal cancer

DNA copy number aberrations (CNA) are frequently observed in colorectal cancers (CRC) . There is an urgent need for CNA-based biomarkers in clinics,. n For Stage III CRC, if combined with imaging or pathologic evidence, these markers promise more precise care. We conducted this Stage III specific bi...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.5009, Article 5009
Hauptverfasser:	Xia, Li C., Van Hummelen, Paul, Kubit, Matthew, Lee, HoJoon, Bell, John M., Grimes, Susan M., Wood-Bouwens, Christina, Greer, Stephanie U., Barker, Tyler, Haslem, Derrick S., Ford, James M., Fulde, Gail, Ji, Hanlee P., Nadauld, Lincoln D.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 631/67/1504 631/67/69 Adult Aged Aged, 80 and over Biomarkers Biomarkers, Tumor Chromosome 17 Chromosome Deletion Chromosomes, Human, Pair 17 - genetics Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Copy number DNA Copy Number Variations - genetics DNA microarrays Female Gene Deletion Genetic Markers Genomes Humanities and Social Sciences Humans Male Medical prognosis Middle Aged multidisciplinary Neoplasm Staging p53 Protein Prognosis Regression analysis Science Science (multidisciplinary) Smith-Magenis Syndrome - diagnosis Smith-Magenis Syndrome - genetics Survival Survival Rate Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Whole genome sequencing Whole Genome Sequencing - methods Young Adult
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