Nonenzymatic function of Aldolase A downregulates miR-145 to promote the Oct4/DUSP4/TRAF4 axis and the acquisition of lung cancer stemness

Drug resistance remains a serious issue of clinical importance and is a consequence of cancer stemness. In this study, we showed that the level of Aldolase A (ALDOA) expression is significantly associated with the IC50 value of chemotherapy drugs in lung cancer. Our data revealed that ALDOA overexpr...

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Veröffentlicht in:	Cell death & disease 2020-03, Vol.11 (3), p.195-195, Article 195
Hauptverfasser:	Chang, Yu-Chan, Yang, Yi-Fang, Chiou, Jean, Tsai, Hsing-Fang, Fang, Chih-Yeu, Yang, Chih-Jen, Chen, Chi-Long, Hsiao, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 38/77 38/89 631/67/2327 631/67/71 64/60 82/51 82/80 Animals Antibodies Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell Line, Tumor Cell Proliferation - physiology Chemotherapy Down-Regulation Drug resistance Dual-Specificity Phosphatases - metabolism Enzymatic activity Fructose-Bisphosphate Aldolase - genetics Fructose-Bisphosphate Aldolase - metabolism Glycolysis Heterografts Humans Immunology Life Sciences Lung cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mice Mice, Inbred NOD Mice, SCID MicroRNAs - genetics MicroRNAs - metabolism Mitogen-Activated Protein Kinase Phosphatases - metabolism Mutants Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oct-4 protein Octamer Transcription Factor-3 - metabolism Signal Transduction TNF Receptor-Associated Factor 4 - metabolism Transcription activation Tumorigenicity Xenografts
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