Build-up functionalization of anti-EGFR × anti-CD3 bispecific diabodies by integrating high-affinity mutants and functional molecular formats

Designing non-natural antibody formats is a practical method for developing highly functional next-generation antibody drugs, particularly for improving the therapeutic efficacy of cancer treatments. One approach is constructing bispecific antibodies (bsAbs). We previously reported a functional huma...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.4913-4913, Article 4913
Hauptverfasser:	Asano, Ryutaro, Hosokawa, Katsuhiro, Taki, Shintaro, Konno, Shota, Shimomura, Ippei, Ogata, Hiromi, Okada, Mai, Arai, Kyoko, Onitsuka, Masayoshi, Omasa, Takeshi, Nakanishi, Takeshi, Umetsu, Mitsuo, Kumagai, Izumi
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 631/1647/664/2228 631/61/338/469 64/60 692/4017 82/103 82/80 82/83 Affinity Antibodies, Bispecific - chemistry Antibodies, Bispecific - genetics Antibodies, Bispecific - immunology Antibodies, Bispecific - pharmacology Antineoplastic Agents, Immunological - chemistry Antineoplastic Agents, Immunological - pharmacology Bispecific antibodies CD3 antigen CD3 Complex - antagonists & inhibitors CD3 Complex - chemistry Cytotoxicity Drug Design Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors ErbB Receptors - chemistry Fc receptors Fusion protein Humanities and Social Sciences multidisciplinary Mutants Mutation Phage display Protein Binding Protein Engineering Recombinant Fusion Proteins Science Science (multidisciplinary) Structure-Activity Relationship
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