Chronic alcohol disrupts hypothalamic responses to stress by modifying CRF and NMDA receptor function

The chronic inability of alcoholics to effectively cope with relapse-inducing stressors has been linked to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and corticotropin-releasing factor (CRF) signaling. However, the cellular mechanisms responsible for this dysregulation are yet to...

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Veröffentlicht in:	Neuropharmacology 2020-05, Vol.167, p.107991-107991, Article 107991
Hauptverfasser:	Marty, Vincent N., Mulpuri, Yatendra, Munier, Joseph J., Spigelman, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcoholism - metabolism Alcoholism - psychology Animals Corticotropin release factor Corticotropin-Releasing Hormone - physiology Ethanol - administration & dosage Ethanol - toxicity Excitatory Postsynaptic Potentials - drug effects Glutamate HPA axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Hypothalamus Male Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Synaptic plasticity
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