Pre-treatment serum bicarbonate predicts for primary tumor control after stereotactic body radiation therapy in patients with localized non-small cell lung cancer

•Pre-treatment bicarbonate is associated with tumor recurrence after lung SBRT.•This remained after accounting for dose, T-stage, tumor volume, and histology.•Findings were validated in an independent cohort from three institutions. Tumor aggressiveness and hypoxia are linked to acidosis in the tumo...

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Veröffentlicht in:	Radiotherapy and oncology 2019-11, Vol.140, p.26-33
Hauptverfasser:	Sebastian, Nikhil, Wu, Trudy, Driscoll, Erin, Willers, Henning, Kelly, Suzanne, Musunuru, Hima Bindu, Mo, Xiaokui, Tan, Yubo, Bazan, Jose, Haglund, Karl, Xu-Welliver, Meng, Baschnagel, Andrew M., Ju, Andrew, Keane, Florence, Williams, Terence M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Bicarbonate Bicarbonates - blood Carcinoma, Non-Small-Cell Lung - blood Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - radiotherapy Female Humans Lung Neoplasms - blood Lung Neoplasms - mortality Lung Neoplasms - radiotherapy Male Middle Aged Non-small cell lung cancer Primary tumor recurrence Radiosurgery Stereotactic body radiation therapy Tumor Microenvironment
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