Influence of cytoskeleton organization on recombinant protein expression by CHO cells

In this study, we assessed the importance of cytoskeleton organization in the mammalian cells used to produce therapeutic proteins. Two cytoskeletal genes, Actin alpha cardiac muscle 1 (ACTC1) and a guanosine triphosphate GTPase‐activating protein (TAGAP), were found to be upregulated in highly prod...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-04, Vol.117 (4), p.1117-1126
Hauptverfasser:	Pourcel, Lucille, Buron, Flavien, Arib, Ghislaine, Le Fourn, Valérie, Regamey, Alexandre, Bodenmann, Iris, Girod, Pierre‐Alain, Mermod, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - chemistry Actin Cytoskeleton - genetics Actin Cytoskeleton - metabolism actin polymerization Actins - genetics Actins - metabolism Animals Cardiac muscle CHO Cells Cricetinae Cricetulus Cytoskeleton cytoskeleton regulation Depolymerization Deprivation GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Guanosine Guanosine triphosphatases Lactic acid Mammalian cells Metabolism Muscles Proteins recombinant protein production Recombinant Proteins - analysis Recombinant Proteins - genetics Recombinant Proteins - metabolism Toxicity Vitamin deficiency
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