FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma
Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations. Cytogenetic, RNA sequencing, and molecular analyses were performed. A FOS-ANKH transcript was found in the first...
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| Veröffentlicht in: | Cancer genomics & proteomics 2020-03, Vol.17 (2), p.161-168 |
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| container_title | Cancer genomics & proteomics |
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| creator | Panagopoulos, Ioannis Gorunova, Ludmila Lobmaier, Ingvild Andersen, Kristin Kostolomov, Ilyá Lund-Iversen, Marius Bjerkehagen, Bodil Heim, Sverre |
| description | Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.
Cytogenetic, RNA sequencing, and molecular analyses were performed.
A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second. Exon 4 of FOS fused with sequences either from intron 1 of ANKH or intron 5 of RUNX2. The fusion events introduced a stop codon and removed sequences involved in the regulation of FOS.
Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3'-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors. |
| doi_str_mv | 10.21873/cgp.20176 |
| format | Article |
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Cytogenetic, RNA sequencing, and molecular analyses were performed.
A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second. Exon 4 of FOS fused with sequences either from intron 1 of ANKH or intron 5 of RUNX2. The fusion events introduced a stop codon and removed sequences involved in the regulation of FOS.
Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3'-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors.</description><identifier>ISSN: 1109-6535</identifier><identifier>EISSN: 1790-6245</identifier><identifier>DOI: 10.21873/cgp.20176</identifier><identifier>PMID: 32108038</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>3' Untranslated regions ; Benign ; Biomedical materials ; Bones ; Cbfa-1 protein ; Connective tissues ; Cytogenetics ; Fibroids ; Gene expression ; Gene sequencing ; Osteoblastoma ; Ribonucleic acid ; RNA ; Stop codon ; Transcription ; Tumors</subject><ispartof>Cancer genomics & proteomics, 2020-03, Vol.17 (2), p.161-168</ispartof><rights>Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.</rights><rights>Copyright International Institute of Anticancer Research Mar/Apr 2020</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>Copyright 2020, International Institute of Anticancer Research 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-7c612d4dbcb768e3c74d047a2a23a772ab5be6f447c325bb3135749e2789be5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078835/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078835/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,26567,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32108038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Panagopoulos, Ioannis</creatorcontrib><creatorcontrib>Gorunova, Ludmila</creatorcontrib><creatorcontrib>Lobmaier, Ingvild</creatorcontrib><creatorcontrib>Andersen, Kristin</creatorcontrib><creatorcontrib>Kostolomov, Ilyá</creatorcontrib><creatorcontrib>Lund-Iversen, Marius</creatorcontrib><creatorcontrib>Bjerkehagen, Bodil</creatorcontrib><creatorcontrib>Heim, Sverre</creatorcontrib><title>FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma</title><title>Cancer genomics & proteomics</title><addtitle>Cancer Genomics Proteomics</addtitle><description>Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.
Cytogenetic, RNA sequencing, and molecular analyses were performed.
A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second. Exon 4 of FOS fused with sequences either from intron 1 of ANKH or intron 5 of RUNX2. The fusion events introduced a stop codon and removed sequences involved in the regulation of FOS.
Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3'-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors.</description><subject>3' Untranslated regions</subject><subject>Benign</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Cbfa-1 protein</subject><subject>Connective tissues</subject><subject>Cytogenetics</subject><subject>Fibroids</subject><subject>Gene expression</subject><subject>Gene sequencing</subject><subject>Osteoblastoma</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Stop codon</subject><subject>Transcription</subject><subject>Tumors</subject><issn>1109-6535</issn><issn>1790-6245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNpVUU1LAzEQDaLYWr34A3TBm7A1ySSb3YtQim3F0oJa8BaS3bRuaZO62RX898Z-iJ5mhnm8eW8eQpcEdylJBdzli02XYiKSI9QmIsNxQhk_Dj3BWZxw4C105v0SYyaA4VPUAkpwiiFtIzaYvsS9ydMoUraIfobn2eSNRoPGl85GQ2ONj0obTX1tnF4pX7u1Okcnc7Xy5mJfO2g2eHjtj-LxdPjY743jnAGuY5EnhBas0LkWSWogF6wIEhRVFJQQVGmuTTJnTORAudZAgAuWGSrSTBuuoIPud7ybRq9NkRtbV2olN1W5VtWXdKqU_ze2fJcL9ykFFmkKPBBc7wjyqvR1aaV1lZLBO6cyhQRYQNzsT1TuozG-lkvXVDa4khQyIIQHaQF1e-Bx3ldm_quBYLnNQIYM5DaDAL76q_oXeng6fAMW634N</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Panagopoulos, Ioannis</creator><creator>Gorunova, Ludmila</creator><creator>Lobmaier, Ingvild</creator><creator>Andersen, Kristin</creator><creator>Kostolomov, Ilyá</creator><creator>Lund-Iversen, Marius</creator><creator>Bjerkehagen, Bodil</creator><creator>Heim, Sverre</creator><general>International Institute of Anticancer Research</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>3HK</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma</title><author>Panagopoulos, Ioannis ; Gorunova, Ludmila ; Lobmaier, Ingvild ; Andersen, Kristin ; Kostolomov, Ilyá ; Lund-Iversen, Marius ; Bjerkehagen, Bodil ; Heim, Sverre</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-7c612d4dbcb768e3c74d047a2a23a772ab5be6f447c325bb3135749e2789be5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3' Untranslated regions</topic><topic>Benign</topic><topic>Biomedical materials</topic><topic>Bones</topic><topic>Cbfa-1 protein</topic><topic>Connective tissues</topic><topic>Cytogenetics</topic><topic>Fibroids</topic><topic>Gene expression</topic><topic>Gene sequencing</topic><topic>Osteoblastoma</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>Stop codon</topic><topic>Transcription</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Panagopoulos, Ioannis</creatorcontrib><creatorcontrib>Gorunova, Ludmila</creatorcontrib><creatorcontrib>Lobmaier, Ingvild</creatorcontrib><creatorcontrib>Andersen, Kristin</creatorcontrib><creatorcontrib>Kostolomov, Ilyá</creatorcontrib><creatorcontrib>Lund-Iversen, Marius</creatorcontrib><creatorcontrib>Bjerkehagen, Bodil</creatorcontrib><creatorcontrib>Heim, Sverre</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer genomics & proteomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Panagopoulos, Ioannis</au><au>Gorunova, Ludmila</au><au>Lobmaier, Ingvild</au><au>Andersen, Kristin</au><au>Kostolomov, Ilyá</au><au>Lund-Iversen, Marius</au><au>Bjerkehagen, Bodil</au><au>Heim, Sverre</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma</atitle><jtitle>Cancer genomics & proteomics</jtitle><addtitle>Cancer Genomics Proteomics</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>17</volume><issue>2</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>1109-6535</issn><eissn>1790-6245</eissn><abstract>Osteoblastoma is a rare benign tumor of the bones in which recurrent rearrangements of FOS have been found. Our aim was to investigate two osteoblastomas for possible genetic aberrations.
Cytogenetic, RNA sequencing, and molecular analyses were performed.
A FOS-ANKH transcript was found in the first tumor, whereas a FOS-RUNX2 was detected in the second. Exon 4 of FOS fused with sequences either from intron 1 of ANKH or intron 5 of RUNX2. The fusion events introduced a stop codon and removed sequences involved in the regulation of FOS.
Rearrangements and fusions of FOS show similarities with those of HMGA2 (a feature of leiomyomas and lipomas) and CSF1 (tenosynovial giant cell tumors). The replacement of a 3'-untranslated region, controlling the gene's expression, by a new sequence is thus a common pathogenetic theme shared by FOS, HMGA2, and CSF1 in many benign connective tissue tumors.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>32108038</pmid><doi>10.21873/cgp.20176</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3' Untranslated regions Benign Biomedical materials Bones Cbfa-1 protein Connective tissues Cytogenetics Fibroids Gene expression Gene sequencing Osteoblastoma Ribonucleic acid RNA Stop codon Transcription Tumors |
| title | FOS-ANKH and FOS-RUNX2 Fusion Genes in Osteoblastoma |
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