A moonlighting nuclease puts CRISPR in its place

Integration of spacers into CRISPR loci requires the Cas1/Cas2 integrase complex, frequently in combination with Cas4 exonuclease. However, several CRISPR-Cas systems lack Cas4. Whether Cas4-like activity is dispensable in these systems or provided by an unidentified actor was not known. In this iss...

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Veröffentlicht in:	The Journal of biological chemistry 2020-03, Vol.295 (11), p.3415-3416
1. Verfasser:	Lawrence, C. Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Associated Proteins - genetics CRISPR-Cas Systems DNA Polymerase III Editors' Picks Highlights Endonucleases - genetics Endonucleases - metabolism Escherichia coli - metabolism Escherichia coli Proteins - metabolism Exonucleases
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