STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination

Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. Dysregulation of STAT3, a transcription factor pivotal to various cellular processes including Th17 cell differentiation, has been implicated in MS. Here, we report that STAT3 is activated in i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-03, Vol.117 (10), p.5430-5441
Hauptverfasser:	Lu, Hsueh Chung, Kim, Sunja, Steelman, Andrew J., Tracy, Kevin, Zhou, Beiyan, Michaud, Danielle, Hillhouse, Andrew E., Konganti, Kranti, Li, Jianrong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Autoimmune diseases Biological Sciences CD11b Antigen - analysis Cell activation Cell Differentiation Central nervous system Demyelinating diseases Demyelination Differentiation (biology) Disruption Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Gene expression Helper cells Humans Immunization Leukocytes Lymphocyte Activation Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL Mice, Mutant Strains Monocytes Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Mutants Myelin Myeloid cells Myeloid Cells - immunology Signaling Single-Cell Analysis Stat3 protein STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism T-Lymphocyte Subsets - immunology Therapeutic applications Transcriptome
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