Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity in Wistar rats
The present study was designed to investigate the chemoprotective effect of green tea extract (GTE), rosmarinic acid (RA) and rosemary extract (RE) against diethylnitrosamine (DEN) initiated and ferric nitrilotriacetate (Fe-NTA) promoted nephrotoxicity in rats. Forty male rats were categorized into...
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| creator | El-Desouky, Mohamed A. Mahmoud, Maha H. Riad, Bahia Y. Taha, Yara M. |
| description | The present study was designed to investigate the chemoprotective effect of green tea extract (GTE), rosmarinic acid (RA) and rosemary extract (RE) against diethylnitrosamine (DEN) initiated and ferric nitrilotriacetate (Fe-NTA) promoted nephrotoxicity in rats. Forty male rats were categorized into five: Group I included healthy rats, group II received DEN+Fe-NTA, group III received 200 mg/kg b.wt. of RE+DEN+Fe-NTA, group IV received 1 g/kg b.wt. of GTE+DEN+Fe-NTA and group V received 50 mg/kg b.wt. of RA+DEN+Fe-NTA. RE, GTE, RA were given orally for 14 days before single intraperitoneal administration of DEN (160 mg/kg) till the end of the experiment. Eighteen days after DEN, a single intraperitoneal dose of Fe-NTA (5 mg Fe/kg) was administrated to rats to promote nephrotoxicity. The biochemical parameters were analyzed in serum at time intervals while the malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) were assessed in both serum and renal tissues. Kidney from each group was histopathologically examined at time intervals. The administration of Fe-NTA after DEN dose to albino rats resulted in acute nephrotoxicity which was characterized by a highly significant elevation of serum urea, creatinine, uric acid (
=0.000), serum and renal MDA and TNF-α (
=0.000) with vacuolation of epithelial lining renal tubules. The administration of RE, GTE and RA prior to DEN+Fe-NTA treatment significantly ameliorated the observed increased levels of the above mentioned parameters. GTE, RA & RE exerted a protective effect against renal toxicity with GTE showing a more pronounced effect on renal function parameters while RA showed the best antioxidant impact. |
| doi_str_mv | 10.2478/intox-2019-0012 |
| format | Article |
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=0.000), serum and renal MDA and TNF-α (
=0.000) with vacuolation of epithelial lining renal tubules. The administration of RE, GTE and RA prior to DEN+Fe-NTA treatment significantly ameliorated the observed increased levels of the above mentioned parameters. GTE, RA & RE exerted a protective effect against renal toxicity with GTE showing a more pronounced effect on renal function parameters while RA showed the best antioxidant impact.</description><identifier>ISSN: 1337-6853</identifier><identifier>ISSN: 1337-9569</identifier><identifier>EISSN: 1337-9569</identifier><identifier>DOI: 10.2478/intox-2019-0012</identifier><identifier>PMID: 32206031</identifier><language>eng</language><publisher>Slovakia: Sciendo</publisher><subject>acidic component ; acute toxicity ; Antioxidants ; Creatinine ; Diethylnitrosamine ; Green tea ; Intervals ; Malondialdehyde ; Original ; Parameters ; phospholipase A ; Renal function ; Renal tubules ; Rodents ; Rosemary ; Rosmarinic acid ; Tea ; Toxicity ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Urea ; Uric acid ; vipoxin</subject><ispartof>Interdisciplinary toxicology, 2019-10, Vol.12 (2), p.98-110</ispartof><rights>Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4558-4e2a8d3bc6a5d3675097003695661e6fff775f807e6a8950c26207f19a05344f3</citedby><cites>FETCH-LOGICAL-c4558-4e2a8d3bc6a5d3675097003695661e6fff775f807e6a8950c26207f19a05344f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071836/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071836/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797,76168,76169</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32206031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Desouky, Mohamed A.</creatorcontrib><creatorcontrib>Mahmoud, Maha H.</creatorcontrib><creatorcontrib>Riad, Bahia Y.</creatorcontrib><creatorcontrib>Taha, Yara M.</creatorcontrib><title>Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity in Wistar rats</title><title>Interdisciplinary toxicology</title><addtitle>Interdiscip Toxicol</addtitle><description>The present study was designed to investigate the chemoprotective effect of green tea extract (GTE), rosmarinic acid (RA) and rosemary extract (RE) against diethylnitrosamine (DEN) initiated and ferric nitrilotriacetate (Fe-NTA) promoted nephrotoxicity in rats. Forty male rats were categorized into five: Group I included healthy rats, group II received DEN+Fe-NTA, group III received 200 mg/kg b.wt. of RE+DEN+Fe-NTA, group IV received 1 g/kg b.wt. of GTE+DEN+Fe-NTA and group V received 50 mg/kg b.wt. of RA+DEN+Fe-NTA. RE, GTE, RA were given orally for 14 days before single intraperitoneal administration of DEN (160 mg/kg) till the end of the experiment. Eighteen days after DEN, a single intraperitoneal dose of Fe-NTA (5 mg Fe/kg) was administrated to rats to promote nephrotoxicity. The biochemical parameters were analyzed in serum at time intervals while the malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) were assessed in both serum and renal tissues. Kidney from each group was histopathologically examined at time intervals. The administration of Fe-NTA after DEN dose to albino rats resulted in acute nephrotoxicity which was characterized by a highly significant elevation of serum urea, creatinine, uric acid (
=0.000), serum and renal MDA and TNF-α (
=0.000) with vacuolation of epithelial lining renal tubules. The administration of RE, GTE and RA prior to DEN+Fe-NTA treatment significantly ameliorated the observed increased levels of the above mentioned parameters. GTE, RA & RE exerted a protective effect against renal toxicity with GTE showing a more pronounced effect on renal function parameters while RA showed the best antioxidant impact.</description><subject>acidic component</subject><subject>acute toxicity</subject><subject>Antioxidants</subject><subject>Creatinine</subject><subject>Diethylnitrosamine</subject><subject>Green tea</subject><subject>Intervals</subject><subject>Malondialdehyde</subject><subject>Original</subject><subject>Parameters</subject><subject>phospholipase A</subject><subject>Renal function</subject><subject>Renal tubules</subject><subject>Rodents</subject><subject>Rosemary</subject><subject>Rosmarinic acid</subject><subject>Tea</subject><subject>Toxicity</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Urea</subject><subject>Uric acid</subject><subject>vipoxin</subject><issn>1337-6853</issn><issn>1337-9569</issn><issn>1337-9569</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kktv1DAQxyMEotXSMzdkiQsHQv1IbEdCSKiigFSVC4ij5TrjXVeJvThOYb8Un7GT7lIeEj7Y4_HPf3seVfWU0Ve8Ufo0xJJ-1JyyrqaU8QfVMRNC1V0ru4cHW-pWHFUn03RNcQjW6kY-ro4E51Ti9rj6eQnbTU7bnAq4Em6AgPdokeTJOgNEUsC-JDlNo80hBkesCz2xsV98gM4dSZFc1n2AstkNMRT02zFEIIiXYAvscQ854_UFCEPCyTooeErw7THdUW7GbYZoB4KRBRfKDkXI1zAVm0m2ZXpSPfJ2mODksK6qL-fvPp99qC8-vf949vaidk3b6roBbnUvrpy0bS-kammnMHyJqZEMpPdeqdZrqkBa3bXUccmp8qyztBVN48WqerPX3c5XI_QOYsl2MNsclohNssH8fRLDxqzTjVFUMS0kCrw4COT0bYapmDFMDobBRkjzZLjQXMqmUQv6_B_0Os0Zk7BQWKWOaazlqjrdUw7zO2Xw959h1CztYO7awSztYJZ2wBvP_ozhnv9VfARe74HvdiiQe1jneYfG7_f_I80477S4BR9Xyfw</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>El-Desouky, Mohamed A.</creator><creator>Mahmoud, Maha H.</creator><creator>Riad, Bahia Y.</creator><creator>Taha, Yara M.</creator><general>Sciendo</general><general>De Gruyter Poland</general><general>Slovak Toxicology Society SETOX</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20191001</creationdate><title>Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity in Wistar rats</title><author>El-Desouky, Mohamed A. ; Mahmoud, Maha H. ; Riad, Bahia Y. ; Taha, Yara M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4558-4e2a8d3bc6a5d3675097003695661e6fff775f807e6a8950c26207f19a05344f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>acidic component</topic><topic>acute toxicity</topic><topic>Antioxidants</topic><topic>Creatinine</topic><topic>Diethylnitrosamine</topic><topic>Green tea</topic><topic>Intervals</topic><topic>Malondialdehyde</topic><topic>Original</topic><topic>Parameters</topic><topic>phospholipase A</topic><topic>Renal function</topic><topic>Renal tubules</topic><topic>Rodents</topic><topic>Rosemary</topic><topic>Rosmarinic acid</topic><topic>Tea</topic><topic>Toxicity</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Urea</topic><topic>Uric acid</topic><topic>vipoxin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Desouky, Mohamed A.</creatorcontrib><creatorcontrib>Mahmoud, Maha H.</creatorcontrib><creatorcontrib>Riad, Bahia Y.</creatorcontrib><creatorcontrib>Taha, Yara M.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Interdisciplinary toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Desouky, Mohamed A.</au><au>Mahmoud, Maha H.</au><au>Riad, Bahia Y.</au><au>Taha, Yara M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity in Wistar rats</atitle><jtitle>Interdisciplinary toxicology</jtitle><addtitle>Interdiscip Toxicol</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>12</volume><issue>2</issue><spage>98</spage><epage>110</epage><pages>98-110</pages><issn>1337-6853</issn><issn>1337-9569</issn><eissn>1337-9569</eissn><abstract>The present study was designed to investigate the chemoprotective effect of green tea extract (GTE), rosmarinic acid (RA) and rosemary extract (RE) against diethylnitrosamine (DEN) initiated and ferric nitrilotriacetate (Fe-NTA) promoted nephrotoxicity in rats. Forty male rats were categorized into five: Group I included healthy rats, group II received DEN+Fe-NTA, group III received 200 mg/kg b.wt. of RE+DEN+Fe-NTA, group IV received 1 g/kg b.wt. of GTE+DEN+Fe-NTA and group V received 50 mg/kg b.wt. of RA+DEN+Fe-NTA. RE, GTE, RA were given orally for 14 days before single intraperitoneal administration of DEN (160 mg/kg) till the end of the experiment. Eighteen days after DEN, a single intraperitoneal dose of Fe-NTA (5 mg Fe/kg) was administrated to rats to promote nephrotoxicity. The biochemical parameters were analyzed in serum at time intervals while the malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) were assessed in both serum and renal tissues. Kidney from each group was histopathologically examined at time intervals. The administration of Fe-NTA after DEN dose to albino rats resulted in acute nephrotoxicity which was characterized by a highly significant elevation of serum urea, creatinine, uric acid (
=0.000), serum and renal MDA and TNF-α (
=0.000) with vacuolation of epithelial lining renal tubules. The administration of RE, GTE and RA prior to DEN+Fe-NTA treatment significantly ameliorated the observed increased levels of the above mentioned parameters. GTE, RA & RE exerted a protective effect against renal toxicity with GTE showing a more pronounced effect on renal function parameters while RA showed the best antioxidant impact.</abstract><cop>Slovakia</cop><pub>Sciendo</pub><pmid>32206031</pmid><doi>10.2478/intox-2019-0012</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acidic component acute toxicity Antioxidants Creatinine Diethylnitrosamine Green tea Intervals Malondialdehyde Original Parameters phospholipase A Renal function Renal tubules Rodents Rosemary Rosmarinic acid Tea Toxicity Tumor necrosis factor-TNF Tumor necrosis factor-α Urea Uric acid vipoxin |
| title | Nephroprotective effect of green tea, rosmarinic acid and rosemary on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute renal toxicity in Wistar rats |
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