Streptococcus gallolyticus abrogates anti-carcinogenic properties of tannic acid on low-passage colorectal carcinomas

The tannase-producing Gram-positive bacterial species Streptococcus gallolyticus subsp. gallolyticus ( Sgg ) is an opportunistic pathogen of the human gut and strongly associated with colorectal cancer (CRC). A unique feature of Sgg is its ability to degrade tannic acids (TA). TA constitute an impor...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.4714, Article 4714
Hauptverfasser:	Oehmcke-Hecht, Sonja, Mandl, Vanessa, Naatz, Lukas Tim, Dühring, Lara, Köhler, Juliane, Kreikemeyer, Bernd, Maletzki, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 14/63 631/67 631/67/1504 96/31 Antineoplastic Agents Biodegradation Biotransformation Carcinogenesis - drug effects Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - drug therapy Colorectal Neoplasms - pathology Cytotoxicity Dose-Response Relationship, Drug Humanities and Social Sciences Humans multidisciplinary Neoplasm Invasiveness Opportunist infection Phytotherapy Pyrogallol Science Science (multidisciplinary) Senescence Streptococcus Streptococcus gallolyticus Streptococcus gallolyticus subspecies gallolyticus - physiology Streptococcus infections Tannase Tannic acid Tannins - metabolism Tannins - pharmacology Tannins - therapeutic use Tumor cells Tumorigenesis
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