Targeting GRP78-dependent AR-V7 protein degradation overcomes castration-resistance in prostate cancer therapy

: Androgen receptor splice variant 7 (AR-V7) is a leading cause of the development of castration-resistant prostate cancer (CRPC). However, the regulation and function of AR-V7 at levels of post-translational modifications in prostate cancer therapy remain poorly understood. Here, we conducted a lib...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (8), p.3366-3381
Hauptverfasser:	Liao, Yuning, Liu, Yuan, Xia, Xiaohong, Shao, Zhenlong, Huang, Chuyi, He, Jinchan, Jiang, Lili, Tang, Daolin, Liu, Jinbao, Huang, Hongbiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - therapeutic use Androgen Receptor Antagonists - therapeutic use Androgens Animals Antibodies Antineoplastic Agents, Phytogenic - therapeutic use Castration Cell Line, Tumor Heat-Shock Proteins - antagonists & inhibitors HEK293 Cells Humans Male Mice Mice, Inbred BALB C Nuclear Proteins - metabolism Plasmids Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Proteolysis Receptors, Androgen - genetics Receptors, Androgen - metabolism Research Paper Ubiquitin-Protein Ligases - metabolism Ubiquitination Xenograft Model Antitumor Assays
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