Tuned near infrared fluorescent hyaluronic acid conjugates for delivery to pancreatic cancer for intraoperative imaging

The prognosis of pancreatic cancer remains poor. Intraoperative fluorescence imaging of tumors could improve staging and surgical resection, thereby improving prognosis. However, imaging pancreatic cancer with macromolecular delivery systems, is often hampered by nonspecific organ accumulation. : We...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (8), p.3413-3429
Hauptverfasser:	Qi, Bowen, Crawford, Ayrianne J, Wojtynek, Nicholas E, Talmon, Geoffrey A, Hollingsworth, Michael A, Ly, Quan P, Mohs, Aaron M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnostic imaging Adenocarcinoma - surgery Aggregates Animals Chromatography Contrast agents Contrast Media - administration & dosage Contrast Media - chemistry Drug Delivery Systems Dyes Female Fluorescent Dyes - administration & dosage Fluorescent Dyes - chemistry Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemistry Intraoperative Care Metastasis Mice, Inbred C57BL Molecular Structure Noise Optical properties Pancreatic cancer Pancreatic Neoplasms - diagnostic imaging Pancreatic Neoplasms - surgery Pharmacokinetics Proteins Research Paper Serum Albumin, Bovine Tumors
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