Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study
This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model. A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of...
Gespeichert in:
| Veröffentlicht in: | Türk göğüs kalp damar cerrahisi dergisi 2020-01, Vol.28 (1), p.151-157 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 157 |
|---|---|
| container_issue | 1 |
| container_start_page | 151 |
| container_title | Türk göğüs kalp damar cerrahisi dergisi |
| container_volume | 28 |
| creator | Durceylan, Erhan Aksu, Ebubekir Boztepe, Hacer Çengelli, Çiğdem Çiftçi Yılmaz, Evrim Dündar Kasapoğlu, Emine Erol, Kevser Sivrikoz, Muammer Cumhur |
| description | This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model.
A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of one-lung ventilation, followed by 30 min of two-lung ventilation. In the melatonin group, the rats were administered 10 mg/kg melatonin intraperitoneally 10 min before the start of the experiment. At the end of both ventilation periods, tissue samples were obtained from the lungs of the control and melatonin groups for biochemical analysis and histopathological examinations. Tissue superoxide dismutase, malondialdehyde, and tumor necrosis factor-alpha levels were measured. Lung tissue samples were examined based on the presence and amount of alveolar congestion, intra-alveolar bleeding, and leukocyte and lymphocyte infiltration.
At the end of the study, lung tissue malondialdehyde (3.8±0.9 vs. 1.8±0.8 μM; p |
| doi_str_mv | 10.5606/tgkdc.dergisi.2020.18261 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7067025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2377683182</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-c649e649ba25384ad0cc0201e656a6cbeadcb9c9bdee3746fe87036b11e17edb3</originalsourceid><addsrcrecordid>eNpVUV1PwyAUJUajy9xfMDz60gmlpZ0PJsviV2KiD_pMKNx2zBZmoVP_vbhNoySEG8459x44CGFKpjkn_CI0r1pNNfSN8WaakpRMaZlyeoBGKc1mSUlzfohGlBGa5LwkJ2ji_YrExSnLyvwYnbCUFnmkjdDqqXcBVDAbwFDXsfLY1biDVgZnjcXO4nawDdaykw1g6b1TRgbQ-N2EZYQh2eIbsMFEkXH2Es8tho819KaLt7LFPgz68xQd1bL1MNmfY_Ryc_28uEseHm_vF_OHRGUpCYni2QzirmSaszKTmigV30iB51xyVYHUqpqpWaUBWJHxGsqCMF5RCrQAXbExutr1XQ9VB1pFC71sxTq6kf2ncNKI_4g1S9G4jSgIL0gcOkbn-wa9exvAB9EZr6BtpQU3eJGyouAli58eqeWOqnrnfQ_17xhKxHdaYpuW2KclvtMS27Si9OyvzV_hTzbsCyZZmKA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2377683182</pqid></control><display><type>article</type><title>Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study</title><source>PubMed Central</source><creator>Durceylan, Erhan ; Aksu, Ebubekir ; Boztepe, Hacer ; Çengelli, Çiğdem ; Çiftçi Yılmaz, Evrim ; Dündar Kasapoğlu, Emine ; Erol, Kevser ; Sivrikoz, Muammer Cumhur</creator><creatorcontrib>Durceylan, Erhan ; Aksu, Ebubekir ; Boztepe, Hacer ; Çengelli, Çiğdem ; Çiftçi Yılmaz, Evrim ; Dündar Kasapoğlu, Emine ; Erol, Kevser ; Sivrikoz, Muammer Cumhur</creatorcontrib><description>This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model.
A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of one-lung ventilation, followed by 30 min of two-lung ventilation. In the melatonin group, the rats were administered 10 mg/kg melatonin intraperitoneally 10 min before the start of the experiment. At the end of both ventilation periods, tissue samples were obtained from the lungs of the control and melatonin groups for biochemical analysis and histopathological examinations. Tissue superoxide dismutase, malondialdehyde, and tumor necrosis factor-alpha levels were measured. Lung tissue samples were examined based on the presence and amount of alveolar congestion, intra-alveolar bleeding, and leukocyte and lymphocyte infiltration.
At the end of the study, lung tissue malondialdehyde (3.8±0.9 vs. 1.8±0.8 μM; p<0.001) and tumor necrosis factor-alpha levels (47.2±15.0 vs. 21.8±7.2 pg/mL; p<0.001) of the melatonin group were found to significantly decrease, compared to the control group. Superoxide dismutase levels of the melatonin group increased at the end of both ventilation periods, and the increase at the end of one-lung ventilation was found to be statistically significant (0.6±0.2 vs. 1.3±0.7 U/mL; p<0.05). Histopathological examination demonstrated that the tissue damage was less in the melatonin group. There was a significant decrease in the alveolar congestion in this group (p=0.0401). Although other histopathological parameters decreased in the melatonin group, no significant difference was found.
Our study results demonstrate that melatonin has protective effects on the lung damage induced by one-lung ventilation both at biochemical and histopathological levels in rats.</description><identifier>ISSN: 1301-5680</identifier><identifier>EISSN: 2149-8156</identifier><identifier>DOI: 10.5606/tgkdc.dergisi.2020.18261</identifier><identifier>PMID: 32175156</identifier><language>eng</language><publisher>Turkey: Bayçınar Medical Publishing</publisher><subject>Original</subject><ispartof>Türk göğüs kalp damar cerrahisi dergisi, 2020-01, Vol.28 (1), p.151-157</ispartof><rights>Copyright © 2020, Turkish Society of Cardiovascular Surgery.</rights><rights>Copyright © 2020, Turkish Society of Cardiovascular Surgery 2020 Turkish Society of Cardiovascular Surgery</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-c649e649ba25384ad0cc0201e656a6cbeadcb9c9bdee3746fe87036b11e17edb3</citedby><orcidid>0000-0002-1054-1156</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067025/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067025/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32175156$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durceylan, Erhan</creatorcontrib><creatorcontrib>Aksu, Ebubekir</creatorcontrib><creatorcontrib>Boztepe, Hacer</creatorcontrib><creatorcontrib>Çengelli, Çiğdem</creatorcontrib><creatorcontrib>Çiftçi Yılmaz, Evrim</creatorcontrib><creatorcontrib>Dündar Kasapoğlu, Emine</creatorcontrib><creatorcontrib>Erol, Kevser</creatorcontrib><creatorcontrib>Sivrikoz, Muammer Cumhur</creatorcontrib><title>Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study</title><title>Türk göğüs kalp damar cerrahisi dergisi</title><addtitle>Turk Gogus Kalp Damar Cerrahisi Derg</addtitle><description>This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model.
A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of one-lung ventilation, followed by 30 min of two-lung ventilation. In the melatonin group, the rats were administered 10 mg/kg melatonin intraperitoneally 10 min before the start of the experiment. At the end of both ventilation periods, tissue samples were obtained from the lungs of the control and melatonin groups for biochemical analysis and histopathological examinations. Tissue superoxide dismutase, malondialdehyde, and tumor necrosis factor-alpha levels were measured. Lung tissue samples were examined based on the presence and amount of alveolar congestion, intra-alveolar bleeding, and leukocyte and lymphocyte infiltration.
At the end of the study, lung tissue malondialdehyde (3.8±0.9 vs. 1.8±0.8 μM; p<0.001) and tumor necrosis factor-alpha levels (47.2±15.0 vs. 21.8±7.2 pg/mL; p<0.001) of the melatonin group were found to significantly decrease, compared to the control group. Superoxide dismutase levels of the melatonin group increased at the end of both ventilation periods, and the increase at the end of one-lung ventilation was found to be statistically significant (0.6±0.2 vs. 1.3±0.7 U/mL; p<0.05). Histopathological examination demonstrated that the tissue damage was less in the melatonin group. There was a significant decrease in the alveolar congestion in this group (p=0.0401). Although other histopathological parameters decreased in the melatonin group, no significant difference was found.
Our study results demonstrate that melatonin has protective effects on the lung damage induced by one-lung ventilation both at biochemical and histopathological levels in rats.</description><subject>Original</subject><issn>1301-5680</issn><issn>2149-8156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVUV1PwyAUJUajy9xfMDz60gmlpZ0PJsviV2KiD_pMKNx2zBZmoVP_vbhNoySEG8459x44CGFKpjkn_CI0r1pNNfSN8WaakpRMaZlyeoBGKc1mSUlzfohGlBGa5LwkJ2ji_YrExSnLyvwYnbCUFnmkjdDqqXcBVDAbwFDXsfLY1biDVgZnjcXO4nawDdaykw1g6b1TRgbQ-N2EZYQh2eIbsMFEkXH2Es8tho819KaLt7LFPgz68xQd1bL1MNmfY_Ryc_28uEseHm_vF_OHRGUpCYni2QzirmSaszKTmigV30iB51xyVYHUqpqpWaUBWJHxGsqCMF5RCrQAXbExutr1XQ9VB1pFC71sxTq6kf2ncNKI_4g1S9G4jSgIL0gcOkbn-wa9exvAB9EZr6BtpQU3eJGyouAli58eqeWOqnrnfQ_17xhKxHdaYpuW2KclvtMS27Si9OyvzV_hTzbsCyZZmKA</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Durceylan, Erhan</creator><creator>Aksu, Ebubekir</creator><creator>Boztepe, Hacer</creator><creator>Çengelli, Çiğdem</creator><creator>Çiftçi Yılmaz, Evrim</creator><creator>Dündar Kasapoğlu, Emine</creator><creator>Erol, Kevser</creator><creator>Sivrikoz, Muammer Cumhur</creator><general>Bayçınar Medical Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1054-1156</orcidid></search><sort><creationdate>20200101</creationdate><title>Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study</title><author>Durceylan, Erhan ; Aksu, Ebubekir ; Boztepe, Hacer ; Çengelli, Çiğdem ; Çiftçi Yılmaz, Evrim ; Dündar Kasapoğlu, Emine ; Erol, Kevser ; Sivrikoz, Muammer Cumhur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c649e649ba25384ad0cc0201e656a6cbeadcb9c9bdee3746fe87036b11e17edb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Durceylan, Erhan</creatorcontrib><creatorcontrib>Aksu, Ebubekir</creatorcontrib><creatorcontrib>Boztepe, Hacer</creatorcontrib><creatorcontrib>Çengelli, Çiğdem</creatorcontrib><creatorcontrib>Çiftçi Yılmaz, Evrim</creatorcontrib><creatorcontrib>Dündar Kasapoğlu, Emine</creatorcontrib><creatorcontrib>Erol, Kevser</creatorcontrib><creatorcontrib>Sivrikoz, Muammer Cumhur</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Türk göğüs kalp damar cerrahisi dergisi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durceylan, Erhan</au><au>Aksu, Ebubekir</au><au>Boztepe, Hacer</au><au>Çengelli, Çiğdem</au><au>Çiftçi Yılmaz, Evrim</au><au>Dündar Kasapoğlu, Emine</au><au>Erol, Kevser</au><au>Sivrikoz, Muammer Cumhur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study</atitle><jtitle>Türk göğüs kalp damar cerrahisi dergisi</jtitle><addtitle>Turk Gogus Kalp Damar Cerrahisi Derg</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>28</volume><issue>1</issue><spage>151</spage><epage>157</epage><pages>151-157</pages><issn>1301-5680</issn><eissn>2149-8156</eissn><abstract>This study aims to investigate the protective effect of melatonin on lung damage induced by one-lung ventilation in a rat model.
A total of 20 healthy, Sprague-Dawley male rats were randomized into two equal groups as control (n=10) and melatonin groups (n=10). The control group underwent 60 min of one-lung ventilation, followed by 30 min of two-lung ventilation. In the melatonin group, the rats were administered 10 mg/kg melatonin intraperitoneally 10 min before the start of the experiment. At the end of both ventilation periods, tissue samples were obtained from the lungs of the control and melatonin groups for biochemical analysis and histopathological examinations. Tissue superoxide dismutase, malondialdehyde, and tumor necrosis factor-alpha levels were measured. Lung tissue samples were examined based on the presence and amount of alveolar congestion, intra-alveolar bleeding, and leukocyte and lymphocyte infiltration.
At the end of the study, lung tissue malondialdehyde (3.8±0.9 vs. 1.8±0.8 μM; p<0.001) and tumor necrosis factor-alpha levels (47.2±15.0 vs. 21.8±7.2 pg/mL; p<0.001) of the melatonin group were found to significantly decrease, compared to the control group. Superoxide dismutase levels of the melatonin group increased at the end of both ventilation periods, and the increase at the end of one-lung ventilation was found to be statistically significant (0.6±0.2 vs. 1.3±0.7 U/mL; p<0.05). Histopathological examination demonstrated that the tissue damage was less in the melatonin group. There was a significant decrease in the alveolar congestion in this group (p=0.0401). Although other histopathological parameters decreased in the melatonin group, no significant difference was found.
Our study results demonstrate that melatonin has protective effects on the lung damage induced by one-lung ventilation both at biochemical and histopathological levels in rats.</abstract><cop>Turkey</cop><pub>Bayçınar Medical Publishing</pub><pmid>32175156</pmid><doi>10.5606/tgkdc.dergisi.2020.18261</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1054-1156</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1301-5680 |
| ispartof | Türk göğüs kalp damar cerrahisi dergisi, 2020-01, Vol.28 (1), p.151-157 |
| issn | 1301-5680 2149-8156 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7067025 |
| source | PubMed Central |
| subjects | Original |
| title | Protective effects of melatonin on lung damage associated with one-lung ventilation: An experimental study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T22%3A16%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effects%20of%20melatonin%20on%20lung%20damage%20associated%20with%20one-lung%20ventilation:%20An%20experimental%20study&rft.jtitle=T%C3%BCrk%20g%C3%B6%C4%9F%C3%BCs%20kalp%20damar%20cerrahisi%20dergisi&rft.au=Durceylan,%20Erhan&rft.date=2020-01-01&rft.volume=28&rft.issue=1&rft.spage=151&rft.epage=157&rft.pages=151-157&rft.issn=1301-5680&rft.eissn=2149-8156&rft_id=info:doi/10.5606/tgkdc.dergisi.2020.18261&rft_dat=%3Cproquest_pubme%3E2377683182%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2377683182&rft_id=info:pmid/32175156&rfr_iscdi=true |