Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas
Large inoperable sacral chordomas show unsatisfactory local control rates even when treated with high dose proton therapy (PT). The aim of this study is assessing feasibility and reporting early results of patients treated with PT and concomitant hyperthermia (HT). Patients had histologically proven...
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| Veröffentlicht in: | British journal of radiology 2020-03, Vol.93 (1107), p.20180883-20180883 |
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| container_title | British journal of radiology |
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| creator | Tran, Sebastien Puric, Emsad Walser, Marc Poel, Robert Datta, Niloy Ranjan Heuberger, Juerg Pica, Alessia Marder, Dietmar Lomax, Nicoletta Bolsi, Alessandra Morach, Petra Bachtiary, Barbara Seddon, Beatrice M Schneider, Ralf Bodis, Stephan Weber, Damien C |
| description | Large inoperable sacral chordomas show unsatisfactory local control rates even when treated with high dose proton therapy (PT). The aim of this study is assessing feasibility and reporting early results of patients treated with PT and concomitant hyperthermia (HT).
Patients had histologically proven unresectable sacral chordomas and received 70 Gy (relative biological effectiveness) in 2.5 Gy fractions with concomitant weekly HT. Toxicity was assessed according to CTCAE_v4. A volumetric tumor response analysis was performed.
Five patients were treated with the combined approach. Median baseline tumor volume was 735 cc (range, 369-1142). All patients completed PT and received a median of 5 HT sessions (range, 2-6). Median follow-up was 18 months (range, 9-26). The volumetric analysis showed an objective response of all tumors (median shrinkage 46%; range, 9-72). All patients experienced acute Grade 2-3 local pain. One patient presented with a late Grade 3 iliac fracture.
Combining PT and HT in large inoperable sacral chordomas is feasible and causes acceptable toxicity. Volumetric analysis shows promising early results, warranting confirmation in the framework of a prospective trial.
This is an encouraging first report of the feasibility and early results of concomitant HT and PT in treating inoperable sacral chordoma. |
| doi_str_mv | 10.1259/bjr.20180883 |
| format | Article |
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Patients had histologically proven unresectable sacral chordomas and received 70 Gy (relative biological effectiveness) in 2.5 Gy fractions with concomitant weekly HT. Toxicity was assessed according to CTCAE_v4. A volumetric tumor response analysis was performed.
Five patients were treated with the combined approach. Median baseline tumor volume was 735 cc (range, 369-1142). All patients completed PT and received a median of 5 HT sessions (range, 2-6). Median follow-up was 18 months (range, 9-26). The volumetric analysis showed an objective response of all tumors (median shrinkage 46%; range, 9-72). All patients experienced acute Grade 2-3 local pain. One patient presented with a late Grade 3 iliac fracture.
Combining PT and HT in large inoperable sacral chordomas is feasible and causes acceptable toxicity. Volumetric analysis shows promising early results, warranting confirmation in the framework of a prospective trial.
This is an encouraging first report of the feasibility and early results of concomitant HT and PT in treating inoperable sacral chordoma.</description><identifier>ISSN: 0007-1285</identifier><identifier>EISSN: 1748-880X</identifier><identifier>DOI: 10.1259/bjr.20180883</identifier><identifier>PMID: 30943055</identifier><language>eng</language><publisher>England: The British Institute of Radiology</publisher><subject>Aged ; Chordoma - diagnostic imaging ; Chordoma - pathology ; Chordoma - therapy ; Combined Modality Therapy - methods ; Feasibility Studies ; Follow-Up Studies ; Humans ; Hyperthermia, Induced - methods ; Male ; Middle Aged ; Proton Therapy - methods ; Proton therapy special feature: Short Communication ; Radiotherapy Dosage ; Relative Biological Effectiveness ; Retrospective Studies ; Sacrum ; Spinal Neoplasms - diagnostic imaging ; Spinal Neoplasms - pathology ; Spinal Neoplasms - therapy ; Time Factors ; Treatment Outcome ; Tumor Burden</subject><ispartof>British journal of radiology, 2020-03, Vol.93 (1107), p.20180883-20180883</ispartof><rights>2020 The Authors. Published by the British Institute of Radiology 2020 The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-acdc434e03de321404cb69e8978254e4b7f917d119b7fceca287f211ade38ec13</citedby><cites>FETCH-LOGICAL-c384t-acdc434e03de321404cb69e8978254e4b7f917d119b7fceca287f211ade38ec13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30943055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tran, Sebastien</creatorcontrib><creatorcontrib>Puric, Emsad</creatorcontrib><creatorcontrib>Walser, Marc</creatorcontrib><creatorcontrib>Poel, Robert</creatorcontrib><creatorcontrib>Datta, Niloy Ranjan</creatorcontrib><creatorcontrib>Heuberger, Juerg</creatorcontrib><creatorcontrib>Pica, Alessia</creatorcontrib><creatorcontrib>Marder, Dietmar</creatorcontrib><creatorcontrib>Lomax, Nicoletta</creatorcontrib><creatorcontrib>Bolsi, Alessandra</creatorcontrib><creatorcontrib>Morach, Petra</creatorcontrib><creatorcontrib>Bachtiary, Barbara</creatorcontrib><creatorcontrib>Seddon, Beatrice M</creatorcontrib><creatorcontrib>Schneider, Ralf</creatorcontrib><creatorcontrib>Bodis, Stephan</creatorcontrib><creatorcontrib>Weber, Damien C</creatorcontrib><title>Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>Large inoperable sacral chordomas show unsatisfactory local control rates even when treated with high dose proton therapy (PT). The aim of this study is assessing feasibility and reporting early results of patients treated with PT and concomitant hyperthermia (HT).
Patients had histologically proven unresectable sacral chordomas and received 70 Gy (relative biological effectiveness) in 2.5 Gy fractions with concomitant weekly HT. Toxicity was assessed according to CTCAE_v4. A volumetric tumor response analysis was performed.
Five patients were treated with the combined approach. Median baseline tumor volume was 735 cc (range, 369-1142). All patients completed PT and received a median of 5 HT sessions (range, 2-6). Median follow-up was 18 months (range, 9-26). The volumetric analysis showed an objective response of all tumors (median shrinkage 46%; range, 9-72). All patients experienced acute Grade 2-3 local pain. One patient presented with a late Grade 3 iliac fracture.
Combining PT and HT in large inoperable sacral chordomas is feasible and causes acceptable toxicity. Volumetric analysis shows promising early results, warranting confirmation in the framework of a prospective trial.
This is an encouraging first report of the feasibility and early results of concomitant HT and PT in treating inoperable sacral chordoma.</description><subject>Aged</subject><subject>Chordoma - diagnostic imaging</subject><subject>Chordoma - pathology</subject><subject>Chordoma - therapy</subject><subject>Combined Modality Therapy - methods</subject><subject>Feasibility Studies</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proton Therapy - methods</subject><subject>Proton therapy special feature: Short Communication</subject><subject>Radiotherapy Dosage</subject><subject>Relative Biological Effectiveness</subject><subject>Retrospective Studies</subject><subject>Sacrum</subject><subject>Spinal Neoplasms - diagnostic imaging</subject><subject>Spinal Neoplasms - pathology</subject><subject>Spinal Neoplasms - therapy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><issn>0007-1285</issn><issn>1748-880X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUuLFTEQhYMoznV051qydGGPefXt9EaQYXzAgBsFd6E6XX1vhnTSJumR_g3-aXOZB7qqqlMfpwoOIa85u-Ci7d8PN-lCMK6Z1vIJ2fFO6UZr9vMp2THGuoYL3Z6RFznfnMa2Z8_JmWS9kqxtd-TPFSS_0YR59SVTCCO9jX6dsSRn6wh-y67qU8FE8xJLky2E4MKBLimWGGg5YoJlo79dOVIbg42zKxAKPW4LptN2dkBdoB7SAWsTqwyDR5rBJvDUHmMa4wz5JXk2gc_46r6ekx-frr5ffmmuv33-evnxurFSq9KAHa2SCpkcUQqumLLDvkfdd1q0CtXQTT3vRs772lm0IHQ3Cc6h4hotl-fkw53vsg4zjhZDqX-YJbkZ0mYiOPP_JrijOcRb07H9vleqGry9N0jx14q5mNlli95DwLhmIwSTXAmtZEXf3aE2xZwTTo9nODOn_EzNzzzkV_E3_772CD8EJv8CRPWcUA</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Tran, Sebastien</creator><creator>Puric, Emsad</creator><creator>Walser, Marc</creator><creator>Poel, Robert</creator><creator>Datta, Niloy Ranjan</creator><creator>Heuberger, Juerg</creator><creator>Pica, Alessia</creator><creator>Marder, Dietmar</creator><creator>Lomax, Nicoletta</creator><creator>Bolsi, Alessandra</creator><creator>Morach, Petra</creator><creator>Bachtiary, Barbara</creator><creator>Seddon, Beatrice M</creator><creator>Schneider, Ralf</creator><creator>Bodis, Stephan</creator><creator>Weber, Damien C</creator><general>The British Institute of Radiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200301</creationdate><title>Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas</title><author>Tran, Sebastien ; Puric, Emsad ; Walser, Marc ; Poel, Robert ; Datta, Niloy Ranjan ; Heuberger, Juerg ; Pica, Alessia ; Marder, Dietmar ; Lomax, Nicoletta ; Bolsi, Alessandra ; Morach, Petra ; Bachtiary, Barbara ; Seddon, Beatrice M ; Schneider, Ralf ; Bodis, Stephan ; Weber, Damien C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-acdc434e03de321404cb69e8978254e4b7f917d119b7fceca287f211ade38ec13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Chordoma - diagnostic imaging</topic><topic>Chordoma - pathology</topic><topic>Chordoma - therapy</topic><topic>Combined Modality Therapy - methods</topic><topic>Feasibility Studies</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proton Therapy - methods</topic><topic>Proton therapy special feature: Short Communication</topic><topic>Radiotherapy Dosage</topic><topic>Relative Biological Effectiveness</topic><topic>Retrospective Studies</topic><topic>Sacrum</topic><topic>Spinal Neoplasms - diagnostic imaging</topic><topic>Spinal Neoplasms - pathology</topic><topic>Spinal Neoplasms - therapy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tran, Sebastien</creatorcontrib><creatorcontrib>Puric, Emsad</creatorcontrib><creatorcontrib>Walser, Marc</creatorcontrib><creatorcontrib>Poel, Robert</creatorcontrib><creatorcontrib>Datta, Niloy Ranjan</creatorcontrib><creatorcontrib>Heuberger, Juerg</creatorcontrib><creatorcontrib>Pica, Alessia</creatorcontrib><creatorcontrib>Marder, Dietmar</creatorcontrib><creatorcontrib>Lomax, Nicoletta</creatorcontrib><creatorcontrib>Bolsi, Alessandra</creatorcontrib><creatorcontrib>Morach, Petra</creatorcontrib><creatorcontrib>Bachtiary, Barbara</creatorcontrib><creatorcontrib>Seddon, Beatrice M</creatorcontrib><creatorcontrib>Schneider, Ralf</creatorcontrib><creatorcontrib>Bodis, Stephan</creatorcontrib><creatorcontrib>Weber, Damien C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tran, Sebastien</au><au>Puric, Emsad</au><au>Walser, Marc</au><au>Poel, Robert</au><au>Datta, Niloy Ranjan</au><au>Heuberger, Juerg</au><au>Pica, Alessia</au><au>Marder, Dietmar</au><au>Lomax, Nicoletta</au><au>Bolsi, Alessandra</au><au>Morach, Petra</au><au>Bachtiary, Barbara</au><au>Seddon, Beatrice M</au><au>Schneider, Ralf</au><au>Bodis, Stephan</au><au>Weber, Damien C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>93</volume><issue>1107</issue><spage>20180883</spage><epage>20180883</epage><pages>20180883-20180883</pages><issn>0007-1285</issn><eissn>1748-880X</eissn><abstract>Large inoperable sacral chordomas show unsatisfactory local control rates even when treated with high dose proton therapy (PT). The aim of this study is assessing feasibility and reporting early results of patients treated with PT and concomitant hyperthermia (HT).
Patients had histologically proven unresectable sacral chordomas and received 70 Gy (relative biological effectiveness) in 2.5 Gy fractions with concomitant weekly HT. Toxicity was assessed according to CTCAE_v4. A volumetric tumor response analysis was performed.
Five patients were treated with the combined approach. Median baseline tumor volume was 735 cc (range, 369-1142). All patients completed PT and received a median of 5 HT sessions (range, 2-6). Median follow-up was 18 months (range, 9-26). The volumetric analysis showed an objective response of all tumors (median shrinkage 46%; range, 9-72). All patients experienced acute Grade 2-3 local pain. One patient presented with a late Grade 3 iliac fracture.
Combining PT and HT in large inoperable sacral chordomas is feasible and causes acceptable toxicity. Volumetric analysis shows promising early results, warranting confirmation in the framework of a prospective trial.
This is an encouraging first report of the feasibility and early results of concomitant HT and PT in treating inoperable sacral chordoma.</abstract><cop>England</cop><pub>The British Institute of Radiology</pub><pmid>30943055</pmid><doi>10.1259/bjr.20180883</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Chordoma - diagnostic imaging Chordoma - pathology Chordoma - therapy Combined Modality Therapy - methods Feasibility Studies Follow-Up Studies Humans Hyperthermia, Induced - methods Male Middle Aged Proton Therapy - methods Proton therapy special feature: Short Communication Radiotherapy Dosage Relative Biological Effectiveness Retrospective Studies Sacrum Spinal Neoplasms - diagnostic imaging Spinal Neoplasms - pathology Spinal Neoplasms - therapy Time Factors Treatment Outcome Tumor Burden |
| title | Early results and volumetric analysis after spot-scanning proton therapy with concomitant hyperthermia in large inoperable sacral chordomas |
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