Clinical pharmacological study of dotinurad administered to male and female elderly or young subjects

Background Dotinurad is a novel selective urate reabsorption inhibitor (SURI) that selectively inhibits the reabsorption of uric acid in renal tubules and promotes the excretion of uric acid into urine. In this study, the effects of age and gender on the pharmacokinetics (PK), pharmacodynamics (PD),...

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Veröffentlicht in:	Clinical and experimental nephrology 2020-03, Vol.24 (Suppl 1), p.8-16
Hauptverfasser:	Nakatani, Hiroshi, Fushimi, Masahiko, Sasaki, Tomomitsu, Okui, Daisuke, Ohashi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Factors Aged Benzothiazoles - administration & dosage Benzothiazoles - adverse effects Body weight Clinical trials Female Females Gender Geriatrics Glucuronides - blood Glucuronides - urine Healthy Volunteers Humans Japan Male Males Medicine Medicine & Public Health Metabolic Clearance Rate Nephrology Oral administration Original Original Article Pharmacodynamics Pharmacokinetics Reabsorption Renal tubules Safety Sex Factors Sulfates - blood Sulfates - urine Uric acid Uric Acid - blood Uric Acid - urine Uricosuric Agents - administration & dosage Urology Young Adult
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