Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya
Indoor residual spraying (IRS) of insecticides is a major vector control strategy for malaria prevention. We evaluated the impact of a single round of IRS with the organophosphate, pirimiphos-methyl (Actellic 300CS), on entomological and parasitological parameters of malaria in Migori County, wester...
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| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.4518, Article 4518 |
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| creator | Abong’o, Bernard Gimnig, John E. Torr, Stephen J. Longman, Bradley Omoke, Diana Muchoki, Margaret ter Kuile, Feiko Ochomo, Eric Munga, Stephen Samuels, Aaron M. Njagi, Kiambo Maas, James Perry, Robert T. Fornadel, Christen Donnelly, Martin J. Oxborough, Richard M. |
| description | Indoor residual spraying (IRS) of insecticides is a major vector control strategy for malaria prevention. We evaluated the impact of a single round of IRS with the organophosphate, pirimiphos-methyl (Actellic 300CS), on entomological and parasitological parameters of malaria in Migori County, western Kenya in 2017, in an area where primary vectors are resistant to pyrethroids but susceptible to the IRS compound. Entomological monitoring was conducted by indoor CDC light trap, pyrethrum spray catches (PSC) and human landing collection (HLC) before and after IRS. The residual effect of the insecticide was assessed monthly by exposing susceptible
An. gambiae
s.s. Kisumu strain to sprayed surfaces in cone assays and measuring mortality at 24 hours. Malaria case burden data were extracted from laboratory records of four health facilities within the sprayed area and two adjacent unsprayed areas. IRS was associated with reductions in
An. funestus
numbers in the intervention areas compared to non-intervention areas by 88% with light traps (risk ratio [RR] 0.12, 95% CI 0.07–0.21, p |
| doi_str_mv | 10.1038/s41598-020-61350-2 |
| format | Article |
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An. gambiae
s.s. Kisumu strain to sprayed surfaces in cone assays and measuring mortality at 24 hours. Malaria case burden data were extracted from laboratory records of four health facilities within the sprayed area and two adjacent unsprayed areas. IRS was associated with reductions in
An. funestus
numbers in the intervention areas compared to non-intervention areas by 88% with light traps (risk ratio [RR] 0.12, 95% CI 0.07–0.21, p < 0.001) and 93% with PSC collections (RR = 0.07, 0.03–0.17, p < 0.001). The corresponding reductions in the numbers of
An. arabiensis
collected by PSC were 69% in the intervention compared to the non-intervention areas (RR = 0.31, 0.14–0.68, p = 0.006), but there was no significant difference with light traps (RR = 0.45, 0.21–0.96, p = 0.05). Before IRS,
An. funestus
accounted for over 80% of
Anopheles
mosquitoes collected by light trap and PSC in all sites. After IRS,
An. arabiensis
accounted for 86% of
Anopheles
collected by PSC and 66% by CDC light trap in the sprayed sites while the proportion in non-intervention sites remained unchanged. No sporozoite infections were detected in intervention areas after IRS and biting rates by
An. funestus
were reduced to near zero.
Anopheles funestus
and
An. arabiensis
were fully susceptible to pirimiphos-methyl and resistant to pyrethroids. The residual effect of Actellic 300CS lasted ten months on mud and concrete walls. Malaria case counts among febrile patients within IRS areas was lower post- compared to pre-IRS by 44%, 65% and 47% in Rongo, Uriri and Nyatike health facilities respectively. A single application of IRS with Actellic 300CS in Migori County provided ten months protection and resulted in the near elimination of the primary malaria vector
An. funestus
and a corresponding reduction of malaria case count among out-patients. The impact was less on
An. arabiensis
, most likely due to their exophilic nature.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-61350-2</identifier><identifier>PMID: 32161302</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45 ; 45/29 ; 45/77 ; 631/158/1745 ; 631/601/1466 ; 692/700/478/174 ; Animals ; Anopheles ; Biting ; Disease transmission ; Disease Vectors ; Entomology ; Geography, Medical ; Health facilities ; Humanities and Social Sciences ; Humans ; Insect Control - methods ; Insecticides ; Insecticides - administration & dosage ; Intervention ; Kenya - epidemiology ; Light traps ; Malaria ; Malaria - epidemiology ; Malaria - parasitology ; Malaria - prevention & control ; Malaria - transmission ; multidisciplinary ; Organophosphates ; Organothiophosphorus Compounds - administration & dosage ; Pirimiphos-methyl ; Pyrethroids ; Residual effects ; Science ; Science (multidisciplinary) ; Seasons ; Spraying ; Vector-borne diseases ; Vectors</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.4518, Article 4518</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-efe25a63a37d0aad6ddc82614165bf57d0d6815af23c97c592270e3ea8e8f36e3</citedby><cites>FETCH-LOGICAL-c532t-efe25a63a37d0aad6ddc82614165bf57d0d6815af23c97c592270e3ea8e8f36e3</cites><orcidid>0000-0003-3663-5617 ; 0000-0002-5038-604X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066154/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066154/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27915,27916,41111,42180,51567,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32161302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abong’o, Bernard</creatorcontrib><creatorcontrib>Gimnig, John E.</creatorcontrib><creatorcontrib>Torr, Stephen J.</creatorcontrib><creatorcontrib>Longman, Bradley</creatorcontrib><creatorcontrib>Omoke, Diana</creatorcontrib><creatorcontrib>Muchoki, Margaret</creatorcontrib><creatorcontrib>ter Kuile, Feiko</creatorcontrib><creatorcontrib>Ochomo, Eric</creatorcontrib><creatorcontrib>Munga, Stephen</creatorcontrib><creatorcontrib>Samuels, Aaron M.</creatorcontrib><creatorcontrib>Njagi, Kiambo</creatorcontrib><creatorcontrib>Maas, James</creatorcontrib><creatorcontrib>Perry, Robert T.</creatorcontrib><creatorcontrib>Fornadel, Christen</creatorcontrib><creatorcontrib>Donnelly, Martin J.</creatorcontrib><creatorcontrib>Oxborough, Richard M.</creatorcontrib><title>Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Indoor residual spraying (IRS) of insecticides is a major vector control strategy for malaria prevention. We evaluated the impact of a single round of IRS with the organophosphate, pirimiphos-methyl (Actellic 300CS), on entomological and parasitological parameters of malaria in Migori County, western Kenya in 2017, in an area where primary vectors are resistant to pyrethroids but susceptible to the IRS compound. Entomological monitoring was conducted by indoor CDC light trap, pyrethrum spray catches (PSC) and human landing collection (HLC) before and after IRS. The residual effect of the insecticide was assessed monthly by exposing susceptible
An. gambiae
s.s. Kisumu strain to sprayed surfaces in cone assays and measuring mortality at 24 hours. Malaria case burden data were extracted from laboratory records of four health facilities within the sprayed area and two adjacent unsprayed areas. IRS was associated with reductions in
An. funestus
numbers in the intervention areas compared to non-intervention areas by 88% with light traps (risk ratio [RR] 0.12, 95% CI 0.07–0.21, p < 0.001) and 93% with PSC collections (RR = 0.07, 0.03–0.17, p < 0.001). The corresponding reductions in the numbers of
An. arabiensis
collected by PSC were 69% in the intervention compared to the non-intervention areas (RR = 0.31, 0.14–0.68, p = 0.006), but there was no significant difference with light traps (RR = 0.45, 0.21–0.96, p = 0.05). Before IRS,
An. funestus
accounted for over 80% of
Anopheles
mosquitoes collected by light trap and PSC in all sites. After IRS,
An. arabiensis
accounted for 86% of
Anopheles
collected by PSC and 66% by CDC light trap in the sprayed sites while the proportion in non-intervention sites remained unchanged. No sporozoite infections were detected in intervention areas after IRS and biting rates by
An. funestus
were reduced to near zero.
Anopheles funestus
and
An. arabiensis
were fully susceptible to pirimiphos-methyl and resistant to pyrethroids. The residual effect of Actellic 300CS lasted ten months on mud and concrete walls. Malaria case counts among febrile patients within IRS areas was lower post- compared to pre-IRS by 44%, 65% and 47% in Rongo, Uriri and Nyatike health facilities respectively. A single application of IRS with Actellic 300CS in Migori County provided ten months protection and resulted in the near elimination of the primary malaria vector
An. funestus
and a corresponding reduction of malaria case count among out-patients. The impact was less on
An. arabiensis
, most likely due to their exophilic nature.</description><subject>45</subject><subject>45/29</subject><subject>45/77</subject><subject>631/158/1745</subject><subject>631/601/1466</subject><subject>692/700/478/174</subject><subject>Animals</subject><subject>Anopheles</subject><subject>Biting</subject><subject>Disease transmission</subject><subject>Disease Vectors</subject><subject>Entomology</subject><subject>Geography, Medical</subject><subject>Health facilities</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Insect Control - methods</subject><subject>Insecticides</subject><subject>Insecticides - administration & dosage</subject><subject>Intervention</subject><subject>Kenya - epidemiology</subject><subject>Light traps</subject><subject>Malaria</subject><subject>Malaria - epidemiology</subject><subject>Malaria - parasitology</subject><subject>Malaria - prevention & control</subject><subject>Malaria - transmission</subject><subject>multidisciplinary</subject><subject>Organophosphates</subject><subject>Organothiophosphorus Compounds - administration & dosage</subject><subject>Pirimiphos-methyl</subject><subject>Pyrethroids</subject><subject>Residual effects</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Seasons</subject><subject>Spraying</subject><subject>Vector-borne diseases</subject><subject>Vectors</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc1u1DAUhS0EotXQF2CBLLEBqSn-iZ1kg1SNKFRtxQJYW3dsZ8ZVYgfbaZWX4hlxmVLaDd7Yss85915_CL2m5IQS3n5INRVdWxFGKkm5IBV7hg4ZqUXFOGPPH50P0FFK16Qswbqadi_RAWe0mAg7RL_Oxwl0xqHHzpsQIo42OTPDgNMUYXF-i29d3uHJRTe6aRdSNdq8Wwb87lRnOwxOY07I-tt7HDy2PocxDGHrdEkoiWXPIaa7_BzBp9Gl5IoQvMEjDBAdYA3J4s0cjfXFgq_cNkSH12H2eTnGtzZlGz2-sH6BV-hFD0OyR_f7Cv04-_R9_aW6_Pr5fH16WWnBWa5sb5kAyYE3hgAYaYxumaQ1lWLTi3JpZEsF9IzrrtGiY6whlltobdtzafkKfdznTvNmtEaXuSIMaip_AHFRAZx6-uLdTm3DjWqIlFTUJeDtfUAMP-cygroOc_SlZ8V4IxnhjHdFxfYqHUNK0fYPFShRd5jVHrMqmNUfzMW9Qm8e9_Zg-Qu1CPheUAgWfjb-q_2f2N-ocrcd</recordid><startdate>20200311</startdate><enddate>20200311</enddate><creator>Abong’o, Bernard</creator><creator>Gimnig, John E.</creator><creator>Torr, Stephen J.</creator><creator>Longman, Bradley</creator><creator>Omoke, Diana</creator><creator>Muchoki, Margaret</creator><creator>ter Kuile, Feiko</creator><creator>Ochomo, Eric</creator><creator>Munga, Stephen</creator><creator>Samuels, Aaron M.</creator><creator>Njagi, Kiambo</creator><creator>Maas, James</creator><creator>Perry, Robert T.</creator><creator>Fornadel, Christen</creator><creator>Donnelly, Martin J.</creator><creator>Oxborough, Richard M.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing 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of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya</title><author>Abong’o, Bernard ; Gimnig, John E. ; Torr, Stephen J. ; Longman, Bradley ; Omoke, Diana ; Muchoki, Margaret ; ter Kuile, Feiko ; Ochomo, Eric ; Munga, Stephen ; Samuels, Aaron M. ; Njagi, Kiambo ; Maas, James ; Perry, Robert T. ; Fornadel, Christen ; Donnelly, Martin J. ; Oxborough, Richard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-efe25a63a37d0aad6ddc82614165bf57d0d6815af23c97c592270e3ea8e8f36e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>45</topic><topic>45/29</topic><topic>45/77</topic><topic>631/158/1745</topic><topic>631/601/1466</topic><topic>692/700/478/174</topic><topic>Animals</topic><topic>Anopheles</topic><topic>Biting</topic><topic>Disease transmission</topic><topic>Disease Vectors</topic><topic>Entomology</topic><topic>Geography, Medical</topic><topic>Health facilities</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Insect Control - methods</topic><topic>Insecticides</topic><topic>Insecticides - administration & dosage</topic><topic>Intervention</topic><topic>Kenya - epidemiology</topic><topic>Light traps</topic><topic>Malaria</topic><topic>Malaria - epidemiology</topic><topic>Malaria - parasitology</topic><topic>Malaria - prevention & control</topic><topic>Malaria - transmission</topic><topic>multidisciplinary</topic><topic>Organophosphates</topic><topic>Organothiophosphorus Compounds - administration & dosage</topic><topic>Pirimiphos-methyl</topic><topic>Pyrethroids</topic><topic>Residual effects</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Seasons</topic><topic>Spraying</topic><topic>Vector-borne diseases</topic><topic>Vectors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abong’o, Bernard</creatorcontrib><creatorcontrib>Gimnig, John E.</creatorcontrib><creatorcontrib>Torr, Stephen J.</creatorcontrib><creatorcontrib>Longman, Bradley</creatorcontrib><creatorcontrib>Omoke, Diana</creatorcontrib><creatorcontrib>Muchoki, Margaret</creatorcontrib><creatorcontrib>ter Kuile, Feiko</creatorcontrib><creatorcontrib>Ochomo, Eric</creatorcontrib><creatorcontrib>Munga, Stephen</creatorcontrib><creatorcontrib>Samuels, Aaron M.</creatorcontrib><creatorcontrib>Njagi, Kiambo</creatorcontrib><creatorcontrib>Maas, James</creatorcontrib><creatorcontrib>Perry, Robert T.</creatorcontrib><creatorcontrib>Fornadel, Christen</creatorcontrib><creatorcontrib>Donnelly, Martin J.</creatorcontrib><creatorcontrib>Oxborough, Richard M.</creatorcontrib><collection>Springer Nature OA Free 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Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abong’o, Bernard</au><au>Gimnig, John E.</au><au>Torr, Stephen J.</au><au>Longman, Bradley</au><au>Omoke, Diana</au><au>Muchoki, Margaret</au><au>ter Kuile, Feiko</au><au>Ochomo, Eric</au><au>Munga, Stephen</au><au>Samuels, Aaron M.</au><au>Njagi, Kiambo</au><au>Maas, James</au><au>Perry, Robert T.</au><au>Fornadel, Christen</au><au>Donnelly, Martin J.</au><au>Oxborough, Richard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-11</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>4518</spage><pages>4518-</pages><artnum>4518</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Indoor residual spraying (IRS) of insecticides is a major vector control strategy for malaria prevention. We evaluated the impact of a single round of IRS with the organophosphate, pirimiphos-methyl (Actellic 300CS), on entomological and parasitological parameters of malaria in Migori County, western Kenya in 2017, in an area where primary vectors are resistant to pyrethroids but susceptible to the IRS compound. Entomological monitoring was conducted by indoor CDC light trap, pyrethrum spray catches (PSC) and human landing collection (HLC) before and after IRS. The residual effect of the insecticide was assessed monthly by exposing susceptible
An. gambiae
s.s. Kisumu strain to sprayed surfaces in cone assays and measuring mortality at 24 hours. Malaria case burden data were extracted from laboratory records of four health facilities within the sprayed area and two adjacent unsprayed areas. IRS was associated with reductions in
An. funestus
numbers in the intervention areas compared to non-intervention areas by 88% with light traps (risk ratio [RR] 0.12, 95% CI 0.07–0.21, p < 0.001) and 93% with PSC collections (RR = 0.07, 0.03–0.17, p < 0.001). The corresponding reductions in the numbers of
An. arabiensis
collected by PSC were 69% in the intervention compared to the non-intervention areas (RR = 0.31, 0.14–0.68, p = 0.006), but there was no significant difference with light traps (RR = 0.45, 0.21–0.96, p = 0.05). Before IRS,
An. funestus
accounted for over 80% of
Anopheles
mosquitoes collected by light trap and PSC in all sites. After IRS,
An. arabiensis
accounted for 86% of
Anopheles
collected by PSC and 66% by CDC light trap in the sprayed sites while the proportion in non-intervention sites remained unchanged. No sporozoite infections were detected in intervention areas after IRS and biting rates by
An. funestus
were reduced to near zero.
Anopheles funestus
and
An. arabiensis
were fully susceptible to pirimiphos-methyl and resistant to pyrethroids. The residual effect of Actellic 300CS lasted ten months on mud and concrete walls. Malaria case counts among febrile patients within IRS areas was lower post- compared to pre-IRS by 44%, 65% and 47% in Rongo, Uriri and Nyatike health facilities respectively. A single application of IRS with Actellic 300CS in Migori County provided ten months protection and resulted in the near elimination of the primary malaria vector
An. funestus
and a corresponding reduction of malaria case count among out-patients. The impact was less on
An. arabiensis
, most likely due to their exophilic nature.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32161302</pmid><doi>10.1038/s41598-020-61350-2</doi><orcidid>https://orcid.org/0000-0003-3663-5617</orcidid><orcidid>https://orcid.org/0000-0002-5038-604X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-03, Vol.10 (1), p.4518, Article 4518 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7066154 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature OA Free Journals; Nature Free; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 45 45/29 45/77 631/158/1745 631/601/1466 692/700/478/174 Animals Anopheles Biting Disease transmission Disease Vectors Entomology Geography, Medical Health facilities Humanities and Social Sciences Humans Insect Control - methods Insecticides Insecticides - administration & dosage Intervention Kenya - epidemiology Light traps Malaria Malaria - epidemiology Malaria - parasitology Malaria - prevention & control Malaria - transmission multidisciplinary Organophosphates Organothiophosphorus Compounds - administration & dosage Pirimiphos-methyl Pyrethroids Residual effects Science Science (multidisciplinary) Seasons Spraying Vector-borne diseases Vectors |
| title | Impact of indoor residual spraying with pirimiphos-methyl (Actellic 300CS) on entomological indicators of transmission and malaria case burden in Migori County, western Kenya |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T05%3A31%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20indoor%20residual%20spraying%20with%20pirimiphos-methyl%20(Actellic%20300CS)%20on%20entomological%20indicators%20of%20transmission%20and%20malaria%20case%20burden%20in%20Migori%20County,%20western%20Kenya&rft.jtitle=Scientific%20reports&rft.au=Abong%E2%80%99o,%20Bernard&rft.date=2020-03-11&rft.volume=10&rft.issue=1&rft.spage=4518&rft.pages=4518-&rft.artnum=4518&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-61350-2&rft_dat=%3Cproquest_pubme%3E2376203239%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2376203239&rft_id=info:pmid/32161302&rfr_iscdi=true |