Oxygen‐dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy
Protoporphyrin IX‐triplet state lifetime technique (PpIX‐TSLT) is a method used to measure oxygen (PO2) in human cells. The aim of this study was to assess the technical feasibility and safety of measuring oxygen‐dependent delayed fluorescence of 5‐aminolevulinic acid (ALA)‐induced PpIX during upper...
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| description | Protoporphyrin IX‐triplet state lifetime technique (PpIX‐TSLT) is a method used to measure oxygen (PO2) in human cells. The aim of this study was to assess the technical feasibility and safety of measuring oxygen‐dependent delayed fluorescence of 5‐aminolevulinic acid (ALA)‐induced PpIX during upper gastrointestinal (GI) endoscopy. Endoscopic delayed fluorescence measurements were performed 4 hours after oral administration of ALA in healthy volunteers. The ALA dose administered was 0, 1, 5 or 20 mg/kg. Measurements were performed at three mucosal spots in the gastric antrum, duodenal bulb and descending duodenum with the catheter above the mucosa and while applying pressure to induce local ischemia and monitor mitochondrial respiration. During two endoscopies, measurements were performed both before and after intravenous administration of butylscopolamine. Delayed fluorescence measurements were successfully performed during all 10 upper GI endoscopies. ALA dose of 5 mg/kg showed adequate signal‐to‐noise ratio (SNR) values >20 without side effects. All pressure measurements showed significant prolongation of delayed fluorescence lifetime compared to measurements performed without pressure (P |
| doi_str_mv | 10.1002/jbio.201900025 |
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Oxygen tension (PO2) can be measured in human cells by delayed fluorescence lifetime quenching of 5‐aminolevulinic acid‐induced protoporphyrin IX. This study aimed to assess the technical feasibility and safety of this technique during upper gastrointestinal endoscopy in the gastrointestinal (GI) tract. The endoscopic delayed fluorescence lifetime measurements in the GI tract were technically feasible and safe. Local mucosal ischemia was introduced temporarily by applying pressure with the probe on the mucosa. The lifetime prolongation demonstrated the oxygen‐dependence of the signal.</description><identifier>ISSN: 1864-063X</identifier><identifier>EISSN: 1864-0648</identifier><identifier>DOI: 10.1002/jbio.201900025</identifier><identifier>PMID: 31140739</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH & Co. KGaA</publisher><subject>5‐aminolevulinic acid (ALA) ; Adult ; Aminolevulinic acid ; Atomic energy levels ; chronic mesenteric ischemia ; COMET ; diagnostics ; Duodenum ; Duodenum - diagnostic imaging ; Duodenum - metabolism ; Endoscopy ; Endoscopy, Gastrointestinal ; Feasibility ; Fluorescence ; Full ; Gastrointestinal tract ; Healthy Volunteers ; Humans ; Intravenous administration ; Ischemia ; Medical instruments ; Mitochondria ; Mucosa ; Oral administration ; Oxygen ; Oxygen - metabolism ; oxygen tension (PO2) ; PpIX‐TSLT ; Pressure ; Pressure effects ; Prolongation ; Protoporphyrin ; Protoporphyrin IX ; Protoporphyrins - metabolism ; Side effects ; Stomach - diagnostic imaging ; Triplet state ; upper gastrointestinal endoscopy</subject><ispartof>Journal of biophotonics, 2019-10, Vol.12 (10), p.e201900025-n/a</ispartof><rights>2019 The Authors. published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 The Authors. Journal of Biophotonics published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2019. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4685-987d532b50c002c69f549f137cabac0a68f7373e1f0e2fb1d3607eaf4b4723f63</citedby><cites>FETCH-LOGICAL-c4685-987d532b50c002c69f549f137cabac0a68f7373e1f0e2fb1d3607eaf4b4723f63</cites><orcidid>0000-0002-6507-5666</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbio.201900025$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbio.201900025$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31140739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dijk, Louisa J. D.</creatorcontrib><creatorcontrib>Ubbink, Rinse</creatorcontrib><creatorcontrib>Terlouw, Luke G.</creatorcontrib><creatorcontrib>Noord, Desirée</creatorcontrib><creatorcontrib>Mik, Egbert G.</creatorcontrib><creatorcontrib>Bruno, Marco J.</creatorcontrib><title>Oxygen‐dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy</title><title>Journal of biophotonics</title><addtitle>J Biophotonics</addtitle><description>Protoporphyrin IX‐triplet state lifetime technique (PpIX‐TSLT) is a method used to measure oxygen (PO2) in human cells. The aim of this study was to assess the technical feasibility and safety of measuring oxygen‐dependent delayed fluorescence of 5‐aminolevulinic acid (ALA)‐induced PpIX during upper gastrointestinal (GI) endoscopy. Endoscopic delayed fluorescence measurements were performed 4 hours after oral administration of ALA in healthy volunteers. The ALA dose administered was 0, 1, 5 or 20 mg/kg. Measurements were performed at three mucosal spots in the gastric antrum, duodenal bulb and descending duodenum with the catheter above the mucosa and while applying pressure to induce local ischemia and monitor mitochondrial respiration. During two endoscopies, measurements were performed both before and after intravenous administration of butylscopolamine. Delayed fluorescence measurements were successfully performed during all 10 upper GI endoscopies. ALA dose of 5 mg/kg showed adequate signal‐to‐noise ratio (SNR) values >20 without side effects. All pressure measurements showed significant prolongation of delayed fluorescence lifetime compared to measurements performed without pressure (P < .001). Measurements before and after administration of butylscopolamine did not differ significantly in the duodenal bulb and descending duodenum. Measurements of oxygen‐dependent delayed fluorescence of ALA‐induced PpIX in the GI tract during upper GI endoscopy are technically feasible and safe.
Oxygen tension (PO2) can be measured in human cells by delayed fluorescence lifetime quenching of 5‐aminolevulinic acid‐induced protoporphyrin IX. This study aimed to assess the technical feasibility and safety of this technique during upper gastrointestinal endoscopy in the gastrointestinal (GI) tract. The endoscopic delayed fluorescence lifetime measurements in the GI tract were technically feasible and safe. Local mucosal ischemia was introduced temporarily by applying pressure with the probe on the mucosa. The lifetime prolongation demonstrated the oxygen‐dependence of the signal.</description><subject>5‐aminolevulinic acid (ALA)</subject><subject>Adult</subject><subject>Aminolevulinic acid</subject><subject>Atomic energy levels</subject><subject>chronic mesenteric ischemia</subject><subject>COMET</subject><subject>diagnostics</subject><subject>Duodenum</subject><subject>Duodenum - diagnostic imaging</subject><subject>Duodenum - metabolism</subject><subject>Endoscopy</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Feasibility</subject><subject>Fluorescence</subject><subject>Full</subject><subject>Gastrointestinal tract</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Intravenous administration</subject><subject>Ischemia</subject><subject>Medical instruments</subject><subject>Mitochondria</subject><subject>Mucosa</subject><subject>Oral administration</subject><subject>Oxygen</subject><subject>Oxygen - metabolism</subject><subject>oxygen tension (PO2)</subject><subject>PpIX‐TSLT</subject><subject>Pressure</subject><subject>Pressure effects</subject><subject>Prolongation</subject><subject>Protoporphyrin</subject><subject>Protoporphyrin IX</subject><subject>Protoporphyrins - metabolism</subject><subject>Side effects</subject><subject>Stomach - diagnostic imaging</subject><subject>Triplet state</subject><subject>upper gastrointestinal endoscopy</subject><issn>1864-063X</issn><issn>1864-0648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkT-P1DAQxSME4o6DlhJZoqHZxY4TO26QuBN_9nTSNiBdZzn2eDerxDZ2AqSjpeMz8knwau_2Dhoqz2h-fvabVxTPCV4SjMvXu7bzyxITgXNXPyhOScOqBWZV8_BY0-uT4klKO4wZpjV9XJxQQirMqTgtfq6_zxtwv3_8MhDAGXAjMtCrGQyy_eQjJA1OA_IWhehHH3wM2zl2Dq2u0QAqTTGjuR23gNLoB6W3SDmDzOSz2jTkItMbNIUAEW1UGqPv3Ahp7JzqUX7TJ-3D_LR4ZFWf4NnNeVZ8fv_u08XHxdX6w-ri7dVCV6ypF6LhpqZlW2OdHWsmbF0JSyjXqlUaK9ZYTjkFYjGUtiWGMsxB2aqteEkto2fFm4NumNoBTHY3RtXLELtBxVl61cm_J67byo3_KjlmNav2Aq9uBKL_MmUfcujykvpeOfBTkmVJSVNTXuKMvvwH3fkpZtt7SgjWUCyaTC0PlI4-pQj2-BmC5T5luU9ZHlPOF17ct3DEb2PNgDgA37oe5v_Iycvz1fpO_A_bkLl6</recordid><startdate>201910</startdate><enddate>201910</enddate><creator>Dijk, Louisa J. D.</creator><creator>Ubbink, Rinse</creator><creator>Terlouw, Luke G.</creator><creator>Noord, Desirée</creator><creator>Mik, Egbert G.</creator><creator>Bruno, Marco J.</creator><general>WILEY‐VCH Verlag GmbH & Co. KGaA</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SP</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>K9.</scope><scope>L7M</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6507-5666</orcidid></search><sort><creationdate>201910</creationdate><title>Oxygen‐dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy</title><author>Dijk, Louisa J. D. ; Ubbink, Rinse ; Terlouw, Luke G. ; Noord, Desirée ; Mik, Egbert G. ; Bruno, Marco J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4685-987d532b50c002c69f549f137cabac0a68f7373e1f0e2fb1d3607eaf4b4723f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>5‐aminolevulinic acid (ALA)</topic><topic>Adult</topic><topic>Aminolevulinic acid</topic><topic>Atomic energy levels</topic><topic>chronic mesenteric ischemia</topic><topic>COMET</topic><topic>diagnostics</topic><topic>Duodenum</topic><topic>Duodenum - diagnostic imaging</topic><topic>Duodenum - metabolism</topic><topic>Endoscopy</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Feasibility</topic><topic>Fluorescence</topic><topic>Full</topic><topic>Gastrointestinal tract</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Intravenous administration</topic><topic>Ischemia</topic><topic>Medical instruments</topic><topic>Mitochondria</topic><topic>Mucosa</topic><topic>Oral administration</topic><topic>Oxygen</topic><topic>Oxygen - metabolism</topic><topic>oxygen tension (PO2)</topic><topic>PpIX‐TSLT</topic><topic>Pressure</topic><topic>Pressure effects</topic><topic>Prolongation</topic><topic>Protoporphyrin</topic><topic>Protoporphyrin IX</topic><topic>Protoporphyrins - metabolism</topic><topic>Side effects</topic><topic>Stomach - diagnostic imaging</topic><topic>Triplet state</topic><topic>upper gastrointestinal endoscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dijk, Louisa J. D.</creatorcontrib><creatorcontrib>Ubbink, Rinse</creatorcontrib><creatorcontrib>Terlouw, Luke G.</creatorcontrib><creatorcontrib>Noord, Desirée</creatorcontrib><creatorcontrib>Mik, Egbert G.</creatorcontrib><creatorcontrib>Bruno, Marco J.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of biophotonics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dijk, Louisa J. D.</au><au>Ubbink, Rinse</au><au>Terlouw, Luke G.</au><au>Noord, Desirée</au><au>Mik, Egbert G.</au><au>Bruno, Marco J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxygen‐dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy</atitle><jtitle>Journal of biophotonics</jtitle><addtitle>J Biophotonics</addtitle><date>2019-10</date><risdate>2019</risdate><volume>12</volume><issue>10</issue><spage>e201900025</spage><epage>n/a</epage><pages>e201900025-n/a</pages><issn>1864-063X</issn><eissn>1864-0648</eissn><abstract>Protoporphyrin IX‐triplet state lifetime technique (PpIX‐TSLT) is a method used to measure oxygen (PO2) in human cells. The aim of this study was to assess the technical feasibility and safety of measuring oxygen‐dependent delayed fluorescence of 5‐aminolevulinic acid (ALA)‐induced PpIX during upper gastrointestinal (GI) endoscopy. Endoscopic delayed fluorescence measurements were performed 4 hours after oral administration of ALA in healthy volunteers. The ALA dose administered was 0, 1, 5 or 20 mg/kg. Measurements were performed at three mucosal spots in the gastric antrum, duodenal bulb and descending duodenum with the catheter above the mucosa and while applying pressure to induce local ischemia and monitor mitochondrial respiration. During two endoscopies, measurements were performed both before and after intravenous administration of butylscopolamine. Delayed fluorescence measurements were successfully performed during all 10 upper GI endoscopies. ALA dose of 5 mg/kg showed adequate signal‐to‐noise ratio (SNR) values >20 without side effects. All pressure measurements showed significant prolongation of delayed fluorescence lifetime compared to measurements performed without pressure (P < .001). Measurements before and after administration of butylscopolamine did not differ significantly in the duodenal bulb and descending duodenum. Measurements of oxygen‐dependent delayed fluorescence of ALA‐induced PpIX in the GI tract during upper GI endoscopy are technically feasible and safe.
Oxygen tension (PO2) can be measured in human cells by delayed fluorescence lifetime quenching of 5‐aminolevulinic acid‐induced protoporphyrin IX. This study aimed to assess the technical feasibility and safety of this technique during upper gastrointestinal endoscopy in the gastrointestinal (GI) tract. The endoscopic delayed fluorescence lifetime measurements in the GI tract were technically feasible and safe. Local mucosal ischemia was introduced temporarily by applying pressure with the probe on the mucosa. The lifetime prolongation demonstrated the oxygen‐dependence of the signal.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH & Co. KGaA</pub><pmid>31140739</pmid><doi>10.1002/jbio.201900025</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6507-5666</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 5‐aminolevulinic acid (ALA) Adult Aminolevulinic acid Atomic energy levels chronic mesenteric ischemia COMET diagnostics Duodenum Duodenum - diagnostic imaging Duodenum - metabolism Endoscopy Endoscopy, Gastrointestinal Feasibility Fluorescence Full Gastrointestinal tract Healthy Volunteers Humans Intravenous administration Ischemia Medical instruments Mitochondria Mucosa Oral administration Oxygen Oxygen - metabolism oxygen tension (PO2) PpIX‐TSLT Pressure Pressure effects Prolongation Protoporphyrin Protoporphyrin IX Protoporphyrins - metabolism Side effects Stomach - diagnostic imaging Triplet state upper gastrointestinal endoscopy |
| title | Oxygen‐dependent delayed fluorescence of protoporphyrin IX measured in the stomach and duodenum during upper gastrointestinal endoscopy |
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