A Tetrahedral Boronic Acid Diester Formed by an Unnatural Amino Acid in the Ligand Pocket of an Engineered Lipocalin

Boronic acids have long been known to form cyclic diesters with cis‐diol compounds, including many carbohydrates. This phenomenon was previously exploited to create an artificial lectin by incorporating p‐borono‐l‐phenylalanine (Bpa) into the ligand pocket of an engineered lipocalin, resulting in a...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2020-02, Vol.21 (4), p.469-472
Hauptverfasser:	Sommer, Carina A., Eichinger, Andreas, Skerra, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Aqueous solutions Benzene Boron Boron Compounds - chemistry boronic acids Carbohydrates Chains cis-diols Communication Communications Coordination compounds Crystal structure Crystallization cyclic diesters Diesters ligand design Ligands Lipocalin lipocalins Lipocalins - chemistry Molecular Conformation pH effects Phenylalanine Phenylalanine - analogs & derivatives Phenylalanine - chemistry Polysaccharides Protein Engineering Structural analysis synthetic biology Thermodynamics
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