Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns
Objective To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak. Methods A prospective study enrolled microcephalic and normocephalic newborns with suspected CZI between January and December 2016. Serology (immuno...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 2020-01, Vol.148 (S2), p.9-14 |
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| creator | Oliveira, João V. Carvalho, Tereza C.X. Giovanetti, Marta Jesus, Jaqueline G. Santos, Cleiton S. Pessoa, Lorena B. Magalhães Filho, Cláudio F.Q. Lima, Jéssica G.S. Carvalho, Daniel A.X. Figueiredo, Eduardo M. Biron, Ana Carolina Santos, Daiana C. Viana, Paloma Duarte, Alan O. Pessoa, Rosana Souza, Gloryane B. Calcagno, Juan I. Lima, Fernanda W.M. Alcantara, Luiz C.J. Siqueira, Isadora C. |
| description | Objective
To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak.
Methods
A prospective study enrolled microcephalic and normocephalic newborns with suspected CZI between January and December 2016. Serology (immunoglobulins IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction (RT‐qPCR) for the Zika virus were performed. Demographic and clinical characteristics of newborns with and without microcephaly were compared.
Results
Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic. The majority of these cases were born between January and May 2016. IgM and IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic newborn blood samples, respectively. Six (24%) microcephalic newborns tested positive for Zika virus by RT‐qPCR in urine or placenta samples. Thirteen (11.8%) normocephalic newborns also tested positive for Zika virus by PCR in urine, plasma, or placenta samples, while IgM antibodies against Zika were detected in 4 (4.2%) others.
Conclusions
Identification of 17 normocephalic CZI cases, confirmed by IgM serology or RT‐qPCR for Zika virus, provides evidence that CZI can present asymptomatically at birth. This finding highlights the need for prenatal and neonatal screening for Zika virus in endemic regions.
Neonatal surveillance for congenital Zika infection in Brazil and the identification of Zika virus in microcephalic and normocephalic newborns. |
| doi_str_mv | 10.1002/ijgo.13042 |
| format | Article |
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To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak.
Methods
A prospective study enrolled microcephalic and normocephalic newborns with suspected CZI between January and December 2016. Serology (immunoglobulins IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction (RT‐qPCR) for the Zika virus were performed. Demographic and clinical characteristics of newborns with and without microcephaly were compared.
Results
Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic. The majority of these cases were born between January and May 2016. IgM and IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic newborn blood samples, respectively. Six (24%) microcephalic newborns tested positive for Zika virus by RT‐qPCR in urine or placenta samples. Thirteen (11.8%) normocephalic newborns also tested positive for Zika virus by PCR in urine, plasma, or placenta samples, while IgM antibodies against Zika were detected in 4 (4.2%) others.
Conclusions
Identification of 17 normocephalic CZI cases, confirmed by IgM serology or RT‐qPCR for Zika virus, provides evidence that CZI can present asymptomatically at birth. This finding highlights the need for prenatal and neonatal screening for Zika virus in endemic regions.
Neonatal surveillance for congenital Zika infection in Brazil and the identification of Zika virus in microcephalic and normocephalic newborns.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1002/ijgo.13042</identifier><identifier>PMID: 31975394</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>Brazil ; Brazil - epidemiology ; Case-Control Studies ; Congenital infection ; Disease Outbreaks ; Female ; Humans ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Infant, Newborn ; Infant, Newborn, Diseases - epidemiology ; Infectious Disease Transmission, Vertical - statistics & numerical data ; Male ; Microcephaly ; Microcephaly - blood ; Microcephaly - epidemiology ; Microcephaly - virology ; Neonatal Screening - methods ; Neonatal surveillance ; Pregnancy ; Pregnancy Complications, Infectious - blood ; Pregnancy Complications, Infectious - epidemiology ; Pregnancy Complications, Infectious - etiology ; Prospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Supplement ; Zika virus ; Zika Virus - isolation & purification ; Zika Virus Infection - blood ; Zika Virus Infection - epidemiology ; Zika Virus Infection - etiology</subject><ispartof>International journal of gynecology and obstetrics, 2020-01, Vol.148 (S2), p.9-14</ispartof><rights>2020 World Health Organization; licensed by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics</rights><rights>2020 World Health Organization; licensed by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4202-72a35e1bc1586f9d8b88066940976c968e82135cc050edb0b5dd887f37ab8db23</citedby><cites>FETCH-LOGICAL-c4202-72a35e1bc1586f9d8b88066940976c968e82135cc050edb0b5dd887f37ab8db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijgo.13042$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijgo.13042$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31975394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliveira, João V.</creatorcontrib><creatorcontrib>Carvalho, Tereza C.X.</creatorcontrib><creatorcontrib>Giovanetti, Marta</creatorcontrib><creatorcontrib>Jesus, Jaqueline G.</creatorcontrib><creatorcontrib>Santos, Cleiton S.</creatorcontrib><creatorcontrib>Pessoa, Lorena B.</creatorcontrib><creatorcontrib>Magalhães Filho, Cláudio F.Q.</creatorcontrib><creatorcontrib>Lima, Jéssica G.S.</creatorcontrib><creatorcontrib>Carvalho, Daniel A.X.</creatorcontrib><creatorcontrib>Figueiredo, Eduardo M.</creatorcontrib><creatorcontrib>Biron, Ana Carolina</creatorcontrib><creatorcontrib>Santos, Daiana C.</creatorcontrib><creatorcontrib>Viana, Paloma</creatorcontrib><creatorcontrib>Duarte, Alan O.</creatorcontrib><creatorcontrib>Pessoa, Rosana</creatorcontrib><creatorcontrib>Souza, Gloryane B.</creatorcontrib><creatorcontrib>Calcagno, Juan I.</creatorcontrib><creatorcontrib>Lima, Fernanda W.M.</creatorcontrib><creatorcontrib>Alcantara, Luiz C.J.</creatorcontrib><creatorcontrib>Siqueira, Isadora C.</creatorcontrib><title>Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Objective
To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak.
Methods
A prospective study enrolled microcephalic and normocephalic newborns with suspected CZI between January and December 2016. Serology (immunoglobulins IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction (RT‐qPCR) for the Zika virus were performed. Demographic and clinical characteristics of newborns with and without microcephaly were compared.
Results
Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic. The majority of these cases were born between January and May 2016. IgM and IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic newborn blood samples, respectively. Six (24%) microcephalic newborns tested positive for Zika virus by RT‐qPCR in urine or placenta samples. Thirteen (11.8%) normocephalic newborns also tested positive for Zika virus by PCR in urine, plasma, or placenta samples, while IgM antibodies against Zika were detected in 4 (4.2%) others.
Conclusions
Identification of 17 normocephalic CZI cases, confirmed by IgM serology or RT‐qPCR for Zika virus, provides evidence that CZI can present asymptomatically at birth. This finding highlights the need for prenatal and neonatal screening for Zika virus in endemic regions.
Neonatal surveillance for congenital Zika infection in Brazil and the identification of Zika virus in microcephalic and normocephalic newborns.</description><subject>Brazil</subject><subject>Brazil - epidemiology</subject><subject>Case-Control Studies</subject><subject>Congenital infection</subject><subject>Disease Outbreaks</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - epidemiology</subject><subject>Infectious Disease Transmission, Vertical - statistics & numerical data</subject><subject>Male</subject><subject>Microcephaly</subject><subject>Microcephaly - blood</subject><subject>Microcephaly - epidemiology</subject><subject>Microcephaly - virology</subject><subject>Neonatal Screening - methods</subject><subject>Neonatal surveillance</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - blood</subject><subject>Pregnancy Complications, Infectious - epidemiology</subject><subject>Pregnancy Complications, Infectious - etiology</subject><subject>Prospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Supplement</subject><subject>Zika virus</subject><subject>Zika Virus - isolation & purification</subject><subject>Zika Virus Infection - blood</subject><subject>Zika Virus Infection - epidemiology</subject><subject>Zika Virus Infection - etiology</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kb1uFDEURi1ERJZAwwMglwixwfb82KaIBBEkQREpgIbGsj13dp3M2Ivt2Wh5Fh42M5klgobKxXd07vX9EHpByTElhL1116twTAtSskdoQQWXy6Lk8jFajCFZcibZIXqa0jUhhHJKn6DDgkpeFbJcoN9fIHiddYfTELfguk57C7gNEdvgV-DdlP1wNxo734LNLnjcDNH5Fc5rwIzQGvfOxmBhs9bdDochmwj6ZuTxV91tdRPiG_wh6l-uezebti4OCTeQ976R1GnXb3LodXYWe7g1Ifr0DB20ukvwfP8eoe-fPn47PV9eXp1dnL6_XNqSETb-UBcVUGNpJepWNsIIQepalkTy2spagGC0qKwlFYHGEFM1jRC8Lbg2ojGsOEIns3czmB4aCz5H3alNdL2OOxW0U_8m3q3VKmwVJ3Upq0nwai-I4ecAKaveJQvTMSEMSbGiLNm4EBUj-npGx5OlFKF9GEOJmupUU53qvs4Rfvn3Yg_on_5GgM7Aretg9x-Vuvh8djVL7wCmcK6x</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Oliveira, João V.</creator><creator>Carvalho, Tereza C.X.</creator><creator>Giovanetti, Marta</creator><creator>Jesus, Jaqueline G.</creator><creator>Santos, Cleiton S.</creator><creator>Pessoa, Lorena B.</creator><creator>Magalhães Filho, Cláudio F.Q.</creator><creator>Lima, Jéssica G.S.</creator><creator>Carvalho, Daniel A.X.</creator><creator>Figueiredo, Eduardo M.</creator><creator>Biron, Ana Carolina</creator><creator>Santos, Daiana C.</creator><creator>Viana, Paloma</creator><creator>Duarte, Alan O.</creator><creator>Pessoa, Rosana</creator><creator>Souza, Gloryane B.</creator><creator>Calcagno, Juan I.</creator><creator>Lima, Fernanda W.M.</creator><creator>Alcantara, Luiz C.J.</creator><creator>Siqueira, Isadora C.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202001</creationdate><title>Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns</title><author>Oliveira, João V. ; Carvalho, Tereza C.X. ; Giovanetti, Marta ; Jesus, Jaqueline G. ; Santos, Cleiton S. ; Pessoa, Lorena B. ; Magalhães Filho, Cláudio F.Q. ; Lima, Jéssica G.S. ; Carvalho, Daniel A.X. ; Figueiredo, Eduardo M. ; Biron, Ana Carolina ; Santos, Daiana C. ; Viana, Paloma ; Duarte, Alan O. ; Pessoa, Rosana ; Souza, Gloryane B. ; Calcagno, Juan I. ; Lima, Fernanda W.M. ; Alcantara, Luiz C.J. ; Siqueira, Isadora C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4202-72a35e1bc1586f9d8b88066940976c968e82135cc050edb0b5dd887f37ab8db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Brazil</topic><topic>Brazil - epidemiology</topic><topic>Case-Control Studies</topic><topic>Congenital infection</topic><topic>Disease Outbreaks</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - epidemiology</topic><topic>Infectious Disease Transmission, Vertical - statistics & numerical data</topic><topic>Male</topic><topic>Microcephaly</topic><topic>Microcephaly - blood</topic><topic>Microcephaly - epidemiology</topic><topic>Microcephaly - virology</topic><topic>Neonatal Screening - methods</topic><topic>Neonatal surveillance</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - blood</topic><topic>Pregnancy Complications, Infectious - epidemiology</topic><topic>Pregnancy Complications, Infectious - etiology</topic><topic>Prospective Studies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Supplement</topic><topic>Zika virus</topic><topic>Zika Virus - isolation & purification</topic><topic>Zika Virus Infection - blood</topic><topic>Zika Virus Infection - epidemiology</topic><topic>Zika Virus Infection - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, João V.</creatorcontrib><creatorcontrib>Carvalho, Tereza C.X.</creatorcontrib><creatorcontrib>Giovanetti, Marta</creatorcontrib><creatorcontrib>Jesus, Jaqueline G.</creatorcontrib><creatorcontrib>Santos, Cleiton S.</creatorcontrib><creatorcontrib>Pessoa, Lorena B.</creatorcontrib><creatorcontrib>Magalhães Filho, Cláudio F.Q.</creatorcontrib><creatorcontrib>Lima, Jéssica G.S.</creatorcontrib><creatorcontrib>Carvalho, Daniel A.X.</creatorcontrib><creatorcontrib>Figueiredo, Eduardo M.</creatorcontrib><creatorcontrib>Biron, Ana Carolina</creatorcontrib><creatorcontrib>Santos, Daiana C.</creatorcontrib><creatorcontrib>Viana, Paloma</creatorcontrib><creatorcontrib>Duarte, Alan O.</creatorcontrib><creatorcontrib>Pessoa, Rosana</creatorcontrib><creatorcontrib>Souza, Gloryane B.</creatorcontrib><creatorcontrib>Calcagno, Juan I.</creatorcontrib><creatorcontrib>Lima, Fernanda W.M.</creatorcontrib><creatorcontrib>Alcantara, Luiz C.J.</creatorcontrib><creatorcontrib>Siqueira, Isadora C.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, João V.</au><au>Carvalho, Tereza C.X.</au><au>Giovanetti, Marta</au><au>Jesus, Jaqueline G.</au><au>Santos, Cleiton S.</au><au>Pessoa, Lorena B.</au><au>Magalhães Filho, Cláudio F.Q.</au><au>Lima, Jéssica G.S.</au><au>Carvalho, Daniel A.X.</au><au>Figueiredo, Eduardo M.</au><au>Biron, Ana Carolina</au><au>Santos, Daiana C.</au><au>Viana, Paloma</au><au>Duarte, Alan O.</au><au>Pessoa, Rosana</au><au>Souza, Gloryane B.</au><au>Calcagno, Juan I.</au><au>Lima, Fernanda W.M.</au><au>Alcantara, Luiz C.J.</au><au>Siqueira, Isadora C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2020-01</date><risdate>2020</risdate><volume>148</volume><issue>S2</issue><spage>9</spage><epage>14</epage><pages>9-14</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><abstract>Objective
To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak.
Methods
A prospective study enrolled microcephalic and normocephalic newborns with suspected CZI between January and December 2016. Serology (immunoglobulins IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction (RT‐qPCR) for the Zika virus were performed. Demographic and clinical characteristics of newborns with and without microcephaly were compared.
Results
Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic. The majority of these cases were born between January and May 2016. IgM and IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic newborn blood samples, respectively. Six (24%) microcephalic newborns tested positive for Zika virus by RT‐qPCR in urine or placenta samples. Thirteen (11.8%) normocephalic newborns also tested positive for Zika virus by PCR in urine, plasma, or placenta samples, while IgM antibodies against Zika were detected in 4 (4.2%) others.
Conclusions
Identification of 17 normocephalic CZI cases, confirmed by IgM serology or RT‐qPCR for Zika virus, provides evidence that CZI can present asymptomatically at birth. This finding highlights the need for prenatal and neonatal screening for Zika virus in endemic regions.
Neonatal surveillance for congenital Zika infection in Brazil and the identification of Zika virus in microcephalic and normocephalic newborns.</abstract><cop>United States</cop><pub>John Wiley and Sons Inc</pub><pmid>31975394</pmid><doi>10.1002/ijgo.13042</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 2020-01, Vol.148 (S2), p.9-14 |
| issn | 0020-7292 1879-3479 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7064952 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Brazil Brazil - epidemiology Case-Control Studies Congenital infection Disease Outbreaks Female Humans Immunoglobulin G - blood Immunoglobulin M - blood Infant, Newborn Infant, Newborn, Diseases - epidemiology Infectious Disease Transmission, Vertical - statistics & numerical data Male Microcephaly Microcephaly - blood Microcephaly - epidemiology Microcephaly - virology Neonatal Screening - methods Neonatal surveillance Pregnancy Pregnancy Complications, Infectious - blood Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - etiology Prospective Studies Reverse Transcriptase Polymerase Chain Reaction Supplement Zika virus Zika Virus - isolation & purification Zika Virus Infection - blood Zika Virus Infection - epidemiology Zika Virus Infection - etiology |
| title | Neonatal surveillance for congenital Zika infection during the 2016 microcephaly outbreak in Salvador, Brazil: Zika virus detection in asymptomatic newborns |
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