Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus
Plasma B-type natriuretic peptide (BNP) is a useful marker for diagnosis of hemodynamically significant PDA (hsPDA) and serial BNP measurement is also valuable for monitoring treatment response. This retrospective study was performed to evaluate whether plasma BNP level can predict treatment respons...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.4430-4430, Article 4430 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4430 |
|---|---|
| container_issue | 1 |
| container_start_page | 4430 |
| container_title | Scientific reports |
| container_volume | 10 |
| creator | Oh, Seong Hee Lee, Byong Sop Jung, Euiseok Oh, Moon Yeon Do, Hyun-Jeong Kim, Ellen Ai-Rhan Kim, Ki-Soo |
| description | Plasma B-type natriuretic peptide (BNP) is a useful marker for diagnosis of hemodynamically significant PDA (hsPDA) and serial BNP measurement is also valuable for monitoring treatment response. This retrospective study was performed to evaluate whether plasma BNP level can predict treatment response to ibuprofen in preterm infants born at |
| doi_str_mv | 10.1038/s41598-020-61291-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7064477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2375808054</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e8f78a3b6cf1ce5806527d17dac4ddd3ad52825e2d2fb0d51a95b3d5e8de72753</originalsourceid><addsrcrecordid>eNp9kTtvFTEQhVcIRKKQP0CBLNHQLPi53m2QIOIlRYICastrzyaOdm3jR65S8s_x5YYQKHDjkeabM2d0uu4pwS8JZuOrzImYxh5T3A-ETqTfPeiOKeaip4zSh_fqo-405yvcnqATJ9Pj7ohRIiQh03H348uq86bR277cREBel-RqguIMihCLs4CM9j4UFBNYZwoqCXTZwBeUIMfgM6ASkJtrTGEBj5zfowXS1spF-5LRzpVLFHXZD9lqSs1Ip0a4kGt-0j1a9Jrh9PY_6b69f_f17GN__vnDp7M3573hkpcexkWOms2DWYgBMeJBUGmJtNpway3TVtCRCqCWLjO2guhJzMwKGC1IKgU76V4fdGOdN7CmmUl6VTG5TacbFbRTf3e8u1QX4VpJPHAuZRN4cSuQwvcKuajNZQPrqj2EmhVlcqBsaFk09Pk_6FWoybfz9lQzP2LBG0UPlEkh5wTLnRmC1T5kdQhZtZDVr5DVrg09u3_G3cjvSBvADkBuLX8B6c_u_8j-BMMTt14</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2375808054</pqid></control><display><type>article</type><title>Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus</title><source>SpringerOpen</source><source>Nature Free</source><source>EZB Free E-Journals</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Oh, Seong Hee ; Lee, Byong Sop ; Jung, Euiseok ; Oh, Moon Yeon ; Do, Hyun-Jeong ; Kim, Ellen Ai-Rhan ; Kim, Ki-Soo</creator><creatorcontrib>Oh, Seong Hee ; Lee, Byong Sop ; Jung, Euiseok ; Oh, Moon Yeon ; Do, Hyun-Jeong ; Kim, Ellen Ai-Rhan ; Kim, Ki-Soo</creatorcontrib><description>Plasma B-type natriuretic peptide (BNP) is a useful marker for diagnosis of hemodynamically significant PDA (hsPDA) and serial BNP measurement is also valuable for monitoring treatment response. This retrospective study was performed to evaluate whether plasma BNP level can predict treatment response to ibuprofen in preterm infants born at <30 weeks of gestation with hsPDA. Plasma BNP was measured before (baseline) and 12 to 24 h after (post-treatment) completion of the first (IBU1) and second (IBU2) course of ibuprofen. We compared the BNP levels of responders (closed or insignificant PDA) with those of non-responders (hsPDA requiring further pharmacologic or surgical closure) to each course of ibuprofen. The treatment response rates for IBU1 (n = 92) and IBU2 (n = 19) were 74% and 26%, respectively. In IBU1, non-responders had lower gestational age and birth weight than responders (both,
P
= 0.004), while in IBU2, non-responders had lower birth weight (
P
= 0.014) and platelet counts (
P
= 0.005) than responders; however, baseline BNP levels did not differ significantly between responders and non-responders in either IBU1 (median 1,434 vs. 1,750 pg/mL) or IBU2 (415 vs. 596 pg/mL). Post-treatment BNP was a useful marker for monitoring treatment efficacy of IBU1 and IBU2 for hsPDA with a cut-off value of 331 pg/mL (
P
< 0.001) and 423 pg/mL(
P
< 0.010), respectively. We did not identify a cut-off baseline BNP level that could predict treatment response to ibuprofen in preterm infants with hsPDA.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-61291-w</identifier><identifier>PMID: 32157119</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/53/2423 ; 692/700/1720/3186 ; Birth weight ; Brain natriuretic peptide ; Congenital diseases ; Coronary vessels ; Gestational age ; Humanities and Social Sciences ; Ibuprofen ; Infants ; multidisciplinary ; Newborn babies ; Nonsteroidal anti-inflammatory drugs ; Peptides ; Premature babies ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.4430-4430, Article 4430</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e8f78a3b6cf1ce5806527d17dac4ddd3ad52825e2d2fb0d51a95b3d5e8de72753</citedby><cites>FETCH-LOGICAL-c474t-e8f78a3b6cf1ce5806527d17dac4ddd3ad52825e2d2fb0d51a95b3d5e8de72753</cites><orcidid>0000-0002-1347-4200</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064477/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064477/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32157119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oh, Seong Hee</creatorcontrib><creatorcontrib>Lee, Byong Sop</creatorcontrib><creatorcontrib>Jung, Euiseok</creatorcontrib><creatorcontrib>Oh, Moon Yeon</creatorcontrib><creatorcontrib>Do, Hyun-Jeong</creatorcontrib><creatorcontrib>Kim, Ellen Ai-Rhan</creatorcontrib><creatorcontrib>Kim, Ki-Soo</creatorcontrib><title>Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Plasma B-type natriuretic peptide (BNP) is a useful marker for diagnosis of hemodynamically significant PDA (hsPDA) and serial BNP measurement is also valuable for monitoring treatment response. This retrospective study was performed to evaluate whether plasma BNP level can predict treatment response to ibuprofen in preterm infants born at <30 weeks of gestation with hsPDA. Plasma BNP was measured before (baseline) and 12 to 24 h after (post-treatment) completion of the first (IBU1) and second (IBU2) course of ibuprofen. We compared the BNP levels of responders (closed or insignificant PDA) with those of non-responders (hsPDA requiring further pharmacologic or surgical closure) to each course of ibuprofen. The treatment response rates for IBU1 (n = 92) and IBU2 (n = 19) were 74% and 26%, respectively. In IBU1, non-responders had lower gestational age and birth weight than responders (both,
P
= 0.004), while in IBU2, non-responders had lower birth weight (
P
= 0.014) and platelet counts (
P
= 0.005) than responders; however, baseline BNP levels did not differ significantly between responders and non-responders in either IBU1 (median 1,434 vs. 1,750 pg/mL) or IBU2 (415 vs. 596 pg/mL). Post-treatment BNP was a useful marker for monitoring treatment efficacy of IBU1 and IBU2 for hsPDA with a cut-off value of 331 pg/mL (
P
< 0.001) and 423 pg/mL(
P
< 0.010), respectively. We did not identify a cut-off baseline BNP level that could predict treatment response to ibuprofen in preterm infants with hsPDA.</description><subject>692/53/2423</subject><subject>692/700/1720/3186</subject><subject>Birth weight</subject><subject>Brain natriuretic peptide</subject><subject>Congenital diseases</subject><subject>Coronary vessels</subject><subject>Gestational age</subject><subject>Humanities and Social Sciences</subject><subject>Ibuprofen</subject><subject>Infants</subject><subject>multidisciplinary</subject><subject>Newborn babies</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Peptides</subject><subject>Premature babies</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kTtvFTEQhVcIRKKQP0CBLNHQLPi53m2QIOIlRYICastrzyaOdm3jR65S8s_x5YYQKHDjkeabM2d0uu4pwS8JZuOrzImYxh5T3A-ETqTfPeiOKeaip4zSh_fqo-405yvcnqATJ9Pj7ohRIiQh03H348uq86bR277cREBel-RqguIMihCLs4CM9j4UFBNYZwoqCXTZwBeUIMfgM6ASkJtrTGEBj5zfowXS1spF-5LRzpVLFHXZD9lqSs1Ip0a4kGt-0j1a9Jrh9PY_6b69f_f17GN__vnDp7M3573hkpcexkWOms2DWYgBMeJBUGmJtNpway3TVtCRCqCWLjO2guhJzMwKGC1IKgU76V4fdGOdN7CmmUl6VTG5TacbFbRTf3e8u1QX4VpJPHAuZRN4cSuQwvcKuajNZQPrqj2EmhVlcqBsaFk09Pk_6FWoybfz9lQzP2LBG0UPlEkh5wTLnRmC1T5kdQhZtZDVr5DVrg09u3_G3cjvSBvADkBuLX8B6c_u_8j-BMMTt14</recordid><startdate>20200310</startdate><enddate>20200310</enddate><creator>Oh, Seong Hee</creator><creator>Lee, Byong Sop</creator><creator>Jung, Euiseok</creator><creator>Oh, Moon Yeon</creator><creator>Do, Hyun-Jeong</creator><creator>Kim, Ellen Ai-Rhan</creator><creator>Kim, Ki-Soo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1347-4200</orcidid></search><sort><creationdate>20200310</creationdate><title>Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus</title><author>Oh, Seong Hee ; Lee, Byong Sop ; Jung, Euiseok ; Oh, Moon Yeon ; Do, Hyun-Jeong ; Kim, Ellen Ai-Rhan ; Kim, Ki-Soo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e8f78a3b6cf1ce5806527d17dac4ddd3ad52825e2d2fb0d51a95b3d5e8de72753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/53/2423</topic><topic>692/700/1720/3186</topic><topic>Birth weight</topic><topic>Brain natriuretic peptide</topic><topic>Congenital diseases</topic><topic>Coronary vessels</topic><topic>Gestational age</topic><topic>Humanities and Social Sciences</topic><topic>Ibuprofen</topic><topic>Infants</topic><topic>multidisciplinary</topic><topic>Newborn babies</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Peptides</topic><topic>Premature babies</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Seong Hee</creatorcontrib><creatorcontrib>Lee, Byong Sop</creatorcontrib><creatorcontrib>Jung, Euiseok</creatorcontrib><creatorcontrib>Oh, Moon Yeon</creatorcontrib><creatorcontrib>Do, Hyun-Jeong</creatorcontrib><creatorcontrib>Kim, Ellen Ai-Rhan</creatorcontrib><creatorcontrib>Kim, Ki-Soo</creatorcontrib><collection>SpringerOpen</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Seong Hee</au><au>Lee, Byong Sop</au><au>Jung, Euiseok</au><au>Oh, Moon Yeon</au><au>Do, Hyun-Jeong</au><au>Kim, Ellen Ai-Rhan</au><au>Kim, Ki-Soo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-10</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>4430</spage><epage>4430</epage><pages>4430-4430</pages><artnum>4430</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Plasma B-type natriuretic peptide (BNP) is a useful marker for diagnosis of hemodynamically significant PDA (hsPDA) and serial BNP measurement is also valuable for monitoring treatment response. This retrospective study was performed to evaluate whether plasma BNP level can predict treatment response to ibuprofen in preterm infants born at <30 weeks of gestation with hsPDA. Plasma BNP was measured before (baseline) and 12 to 24 h after (post-treatment) completion of the first (IBU1) and second (IBU2) course of ibuprofen. We compared the BNP levels of responders (closed or insignificant PDA) with those of non-responders (hsPDA requiring further pharmacologic or surgical closure) to each course of ibuprofen. The treatment response rates for IBU1 (n = 92) and IBU2 (n = 19) were 74% and 26%, respectively. In IBU1, non-responders had lower gestational age and birth weight than responders (both,
P
= 0.004), while in IBU2, non-responders had lower birth weight (
P
= 0.014) and platelet counts (
P
= 0.005) than responders; however, baseline BNP levels did not differ significantly between responders and non-responders in either IBU1 (median 1,434 vs. 1,750 pg/mL) or IBU2 (415 vs. 596 pg/mL). Post-treatment BNP was a useful marker for monitoring treatment efficacy of IBU1 and IBU2 for hsPDA with a cut-off value of 331 pg/mL (
P
< 0.001) and 423 pg/mL(
P
< 0.010), respectively. We did not identify a cut-off baseline BNP level that could predict treatment response to ibuprofen in preterm infants with hsPDA.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32157119</pmid><doi>10.1038/s41598-020-61291-w</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-1347-4200</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2020-03, Vol.10 (1), p.4430-4430, Article 4430 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7064477 |
| source | SpringerOpen; Nature Free; EZB Free E-Journals; DOAJ Directory of Open Access Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 692/53/2423 692/700/1720/3186 Birth weight Brain natriuretic peptide Congenital diseases Coronary vessels Gestational age Humanities and Social Sciences Ibuprofen Infants multidisciplinary Newborn babies Nonsteroidal anti-inflammatory drugs Peptides Premature babies Science Science (multidisciplinary) |
| title | Plasma B-type natriuretic peptide cannot predict treatment response to ibuprofen in preterm infants with patent ductus arteriosus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T18%3A05%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20B-type%20natriuretic%20peptide%20cannot%20predict%20treatment%20response%20to%20ibuprofen%20in%20preterm%20infants%20with%20patent%20ductus%20arteriosus&rft.jtitle=Scientific%20reports&rft.au=Oh,%20Seong%20Hee&rft.date=2020-03-10&rft.volume=10&rft.issue=1&rft.spage=4430&rft.epage=4430&rft.pages=4430-4430&rft.artnum=4430&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-020-61291-w&rft_dat=%3Cproquest_pubme%3E2375808054%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2375808054&rft_id=info:pmid/32157119&rfr_iscdi=true |