Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX)

Perfluorooctanoic acid (PFOA) is a poly- and perfluoroalkyl substance (PFAS) associated with adverse pregnancy outcomes in mice and humans, but little is known regarding one of its replacements, hexafluoropropylene oxide dimer acid (HFPO-DA, referred to here as GenX), both of which have been reporte...

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Veröffentlicht in:	Environmental health perspectives 2020-02, Vol.128 (2), p.27006
Hauptverfasser:	Blake, Bevin E, Cope, Harlie A, Hall, Samantha M, Keys, Robert D, Mahler, Beth W, McCord, James, Scott, Brittany, Stapleton, Heather M, Strynar, Mark J, Elmore, Susan A, Fenton, Suzanne E
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Acids Animals Birth weight Caprylates - toxicity Constellations Contaminants Dimers Dosimeters Dosimetry Drinking water Embryos Exposure Female Females Fluorocarbons - toxicity Gene expression Histopathology Humidity Hydrocarbons, Fluorinated - toxicity Latency Liver Mice Neprilysin Perfluoro compounds Perfluoroalkyl & polyfluoroalkyl substances Perfluorooctanoic acid Placenta Placenta - drug effects Pregnancy Pregnancy - drug effects Studies Thyroid Toxicity Toxicity Tests Water pollution Water pollution effects Weight
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