Comprehensive autophagy evaluation in cardiac disease models
Abstract Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the...
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| Veröffentlicht in: | Cardiovascular research 2020-03, Vol.116 (3), p.483-504 |
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| creator | Kaludercic, Nina Maiuri, Maria Chiara Kaushik, Susmita Fernández, Álvaro F de Bruijn, Jenny Castoldi, Francesca Chen, Yun Ito, Jumpei Mukai, Risa Murakawa, Tomokazu Nah, Jihoon Pietrocola, Federico Saito, Toshiro Sebti, Salwa Semenzato, Martina Tsansizi, Lorenza Sciarretta, Sebastiano Madrigal-Matute, Julio |
| description | Abstract
Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system. |
| doi_str_mv | 10.1093/cvr/cvz233 |
| format | Article |
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Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/cvz233</identifier><identifier>PMID: 31504266</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Cardiology and cardiovascular system ; Cellular Biology ; Editor's Choice ; Human health and pathology ; Life Sciences ; Reviews ; Subcellular Processes</subject><ispartof>Cardiovascular research, 2020-03, Vol.116 (3), p.483-504</ispartof><rights>The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology. 2019</rights><rights>Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-693364b9c567e0d689c0d5f4893a0bc0d8d9b3956912739459ebc0fde273fd473</citedby><cites>FETCH-LOGICAL-c549t-693364b9c567e0d689c0d5f4893a0bc0d8d9b3956912739459ebc0fde273fd473</cites><orcidid>0000-0003-0845-9265 ; 0000-0003-4669-4100 ; 0000-0001-9273-6047 ; 0000-0002-2930-234X ; 0000-0003-1365-3863 ; 0000-0002-0894-5450 ; 0000-0002-8447-6246 ; 0000-0001-5149-9962 ; 0000-0002-2587-9483 ; 0000-0002-7704-4285 ; 0000-0003-4327-1129 ; 0000-0003-2254-2233 ; 0000-0001-9760-7674</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,1583,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31504266$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-02537153$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaludercic, Nina</creatorcontrib><creatorcontrib>Maiuri, Maria Chiara</creatorcontrib><creatorcontrib>Kaushik, Susmita</creatorcontrib><creatorcontrib>Fernández, Álvaro F</creatorcontrib><creatorcontrib>de Bruijn, Jenny</creatorcontrib><creatorcontrib>Castoldi, Francesca</creatorcontrib><creatorcontrib>Chen, Yun</creatorcontrib><creatorcontrib>Ito, Jumpei</creatorcontrib><creatorcontrib>Mukai, Risa</creatorcontrib><creatorcontrib>Murakawa, Tomokazu</creatorcontrib><creatorcontrib>Nah, Jihoon</creatorcontrib><creatorcontrib>Pietrocola, Federico</creatorcontrib><creatorcontrib>Saito, Toshiro</creatorcontrib><creatorcontrib>Sebti, Salwa</creatorcontrib><creatorcontrib>Semenzato, Martina</creatorcontrib><creatorcontrib>Tsansizi, Lorenza</creatorcontrib><creatorcontrib>Sciarretta, Sebastiano</creatorcontrib><creatorcontrib>Madrigal-Matute, Julio</creatorcontrib><title>Comprehensive autophagy evaluation in cardiac disease models</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Abstract
Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.</description><subject>Cardiology and cardiovascular system</subject><subject>Cellular Biology</subject><subject>Editor's Choice</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Reviews</subject><subject>Subcellular Processes</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kVFr1TAUx4Mo7rr54geQvgg6qCY9SdrAEMbFbcIFX9xzyE1OdyNtU5O2sH16MzqH7mEPITknv_ML4U_IO0Y_M6rgi11iXncVwAuyYbUQJVRcvCQbSmlTSpBwRN6k9CuXQtT8NTkCJiivpNyQs23ox4gHHJJfsDDzFMaDubktcDHdbCYfhsIPhTXReWML5xOahEUfHHbphLxqTZfw7cN-TK4vvv3cXpW7H5fft-e70gquplIqAMn3ygpZI3WyUZY60fJGgaH7fG6c2oMSUrGqBsWFwtxtHeaqdbyGY_J19Y7zvkdncZii6fQYfW_irQ7G6_9vBn_QN2HRNZWcCpoFn1bB4cnY1flO3_doJaBmAhaW2Y8Pj8Xwe8Y06d4ni11nBgxz0lXVNDVrgEJGT1fUxpBSxPbRzai-j0bnaPQaTYbf__uJR_RvFhn4sAJhHp8T_QEXg5d0</recordid><startdate>20200301</startdate><enddate>20200301</enddate><creator>Kaludercic, Nina</creator><creator>Maiuri, Maria Chiara</creator><creator>Kaushik, Susmita</creator><creator>Fernández, Álvaro F</creator><creator>de Bruijn, Jenny</creator><creator>Castoldi, Francesca</creator><creator>Chen, Yun</creator><creator>Ito, Jumpei</creator><creator>Mukai, Risa</creator><creator>Murakawa, Tomokazu</creator><creator>Nah, Jihoon</creator><creator>Pietrocola, Federico</creator><creator>Saito, Toshiro</creator><creator>Sebti, Salwa</creator><creator>Semenzato, Martina</creator><creator>Tsansizi, Lorenza</creator><creator>Sciarretta, Sebastiano</creator><creator>Madrigal-Matute, Julio</creator><general>Oxford University Press</general><general>Oxford University Press (OUP)</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0845-9265</orcidid><orcidid>https://orcid.org/0000-0003-4669-4100</orcidid><orcidid>https://orcid.org/0000-0001-9273-6047</orcidid><orcidid>https://orcid.org/0000-0002-2930-234X</orcidid><orcidid>https://orcid.org/0000-0003-1365-3863</orcidid><orcidid>https://orcid.org/0000-0002-0894-5450</orcidid><orcidid>https://orcid.org/0000-0002-8447-6246</orcidid><orcidid>https://orcid.org/0000-0001-5149-9962</orcidid><orcidid>https://orcid.org/0000-0002-2587-9483</orcidid><orcidid>https://orcid.org/0000-0002-7704-4285</orcidid><orcidid>https://orcid.org/0000-0003-4327-1129</orcidid><orcidid>https://orcid.org/0000-0003-2254-2233</orcidid><orcidid>https://orcid.org/0000-0001-9760-7674</orcidid></search><sort><creationdate>20200301</creationdate><title>Comprehensive autophagy evaluation in cardiac disease models</title><author>Kaludercic, Nina ; 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Autophagy is a highly conserved recycling mechanism essential for maintaining cellular homeostasis. The pathophysiological role of autophagy has been explored since its discovery 50 years ago, but interest in autophagy has grown exponentially over the last years. Many researchers around the globe have found that autophagy is a critical pathway involved in the pathogenesis of cardiac diseases. Several groups have created novel and powerful tools for gaining deeper insights into the role of autophagy in the aetiology and development of pathologies affecting the heart. Here, we discuss how established and emerging methods to study autophagy can be used to unravel the precise function of this central recycling mechanism in the cardiac system.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31504266</pmid><doi>10.1093/cvr/cvz233</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0003-0845-9265</orcidid><orcidid>https://orcid.org/0000-0003-4669-4100</orcidid><orcidid>https://orcid.org/0000-0001-9273-6047</orcidid><orcidid>https://orcid.org/0000-0002-2930-234X</orcidid><orcidid>https://orcid.org/0000-0003-1365-3863</orcidid><orcidid>https://orcid.org/0000-0002-0894-5450</orcidid><orcidid>https://orcid.org/0000-0002-8447-6246</orcidid><orcidid>https://orcid.org/0000-0001-5149-9962</orcidid><orcidid>https://orcid.org/0000-0002-2587-9483</orcidid><orcidid>https://orcid.org/0000-0002-7704-4285</orcidid><orcidid>https://orcid.org/0000-0003-4327-1129</orcidid><orcidid>https://orcid.org/0000-0003-2254-2233</orcidid><orcidid>https://orcid.org/0000-0001-9760-7674</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Cardiovascular research, 2020-03, Vol.116 (3), p.483-504 |
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| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Cardiology and cardiovascular system Cellular Biology Editor's Choice Human health and pathology Life Sciences Reviews Subcellular Processes |
| title | Comprehensive autophagy evaluation in cardiac disease models |
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