Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study
To assess the role of human platelet antigens (HPA), P-selectin gene (SELP) polymorphisms, and HPA and SELP haplotypes with factor V (FV) R506Q in ischemic pediatric stroke (IPS) subtypes: cerebral sinovenous thrombosis (CSVT), perinatal (PAIS), and childhood (CAIS) arterial ischemic stroke. This ca...
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creator | Čeri, Andrea Leniček Krleža, Jasna Coen Herak, Désirée Miloš, Marija Pavić, Marina Barišić, Nina Đuranović, Vlasta Zadro, Renata |
description | To assess the role of human platelet antigens (HPA), P-selectin gene (SELP) polymorphisms, and HPA and SELP haplotypes with factor V (FV) R506Q in ischemic pediatric stroke (IPS) subtypes: cerebral sinovenous thrombosis (CSVT), perinatal (PAIS), and childhood (CAIS) arterial ischemic stroke.
This case-control study enrolled 150 children with confirmed IPS and 150 age- and sex-matched controls. FV R506Q and HPA-1 were genotyped with CVD StripAssay®, HPA-2 and HPA-3 with real-time polymerase chain reaction, SELP S290N, V599L, and T715P with high resolution melting analysis, and SELP N562D with sequence-specific polymerase chain reaction.
HPA-1b allele (odds ratio [OR] 2.75, 95% confidence interval [CI] 1.02-7.42, P=0.048) and HPA-1a2a3b (OR 5.46, 95% CI 1.51-19.76, P=0.011), HPA-1b2a3a (OR 7.00, 95% CI 1.25-39.13, P=0.028), and HPA-1b2b3a (OR 11.39, 95% CI 1.39-92.95, P=0.024) haplotypes increased the risk for CSVT. HPA-3b allele was significantly associated with 2-fold lower risk for PAIS (OR 0.49, 95% CI 0.26-0.89, P=0.020) and CAIS (OR 0.47, 95% CI 0.26-0.86, P=0.014) and non-significantly associated with increased risk for CSVT (OR 6.43, 95% CI 0.83-50.00, P=0.022). HPA-1a2b3a haplotype was significantly associated with CAIS (OR 6.76, 95% CI 2.13-21.44, P=0.001). The inclusion of FV R506Q in SELP haplotype analysis increased the risk for PAIS 4-fold in QNDVT carriers (OR 8.14, 95% CI 0.93-71.33, P=0.060) compared with NDVT haplotype (OR 2.45, 95% CI 0.98-6.18, P=0.058), but the result was not significant.
Individual HPAs, and particularly HPA haplotypes, are involved in IPS subtypes pathogenesis. A possible risk-inducing synergistic effect of SELP haplotypes with FV R506Q is restricted to PAIS only. |
doi_str_mv | 10.3325/cmj.2020.61.18 |
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This case-control study enrolled 150 children with confirmed IPS and 150 age- and sex-matched controls. FV R506Q and HPA-1 were genotyped with CVD StripAssay®, HPA-2 and HPA-3 with real-time polymerase chain reaction, SELP S290N, V599L, and T715P with high resolution melting analysis, and SELP N562D with sequence-specific polymerase chain reaction.
HPA-1b allele (odds ratio [OR] 2.75, 95% confidence interval [CI] 1.02-7.42, P=0.048) and HPA-1a2a3b (OR 5.46, 95% CI 1.51-19.76, P=0.011), HPA-1b2a3a (OR 7.00, 95% CI 1.25-39.13, P=0.028), and HPA-1b2b3a (OR 11.39, 95% CI 1.39-92.95, P=0.024) haplotypes increased the risk for CSVT. HPA-3b allele was significantly associated with 2-fold lower risk for PAIS (OR 0.49, 95% CI 0.26-0.89, P=0.020) and CAIS (OR 0.47, 95% CI 0.26-0.86, P=0.014) and non-significantly associated with increased risk for CSVT (OR 6.43, 95% CI 0.83-50.00, P=0.022). HPA-1a2b3a haplotype was significantly associated with CAIS (OR 6.76, 95% CI 2.13-21.44, P=0.001). The inclusion of FV R506Q in SELP haplotype analysis increased the risk for PAIS 4-fold in QNDVT carriers (OR 8.14, 95% CI 0.93-71.33, P=0.060) compared with NDVT haplotype (OR 2.45, 95% CI 0.98-6.18, P=0.058), but the result was not significant.
Individual HPAs, and particularly HPA haplotypes, are involved in IPS subtypes pathogenesis. A possible risk-inducing synergistic effect of SELP haplotypes with FV R506Q is restricted to PAIS only.</description><identifier>ISSN: 0353-9504</identifier><identifier>EISSN: 1332-8166</identifier><identifier>DOI: 10.3325/cmj.2020.61.18</identifier><identifier>PMID: 32118374</identifier><identifier>CODEN: CMEJEN</identifier><language>eng</language><publisher>Croatia: Medicinski fakultet Sveučilišta u Zagrebu, Medicinski fakultet Sveučilišta u Splitu, Medicinski fakultet Sveučilišta u Rijeci</publisher><ispartof>Croatian medical journal, 2020-02, Vol.61 (1), p.18-27</ispartof><rights>Copyright © 2020 by the Croatian Medical Journal. All rights reserved. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-8b05cf4149b612982bb22d888a49b34601bc40e67347bca59e382e6f4492724f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063553/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063553/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32118374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Čeri, Andrea</creatorcontrib><creatorcontrib>Leniček Krleža, Jasna</creatorcontrib><creatorcontrib>Coen Herak, Désirée</creatorcontrib><creatorcontrib>Miloš, Marija</creatorcontrib><creatorcontrib>Pavić, Marina</creatorcontrib><creatorcontrib>Barišić, Nina</creatorcontrib><creatorcontrib>Đuranović, Vlasta</creatorcontrib><creatorcontrib>Zadro, Renata</creatorcontrib><title>Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study</title><title>Croatian medical journal</title><addtitle>Croat Med J</addtitle><description>To assess the role of human platelet antigens (HPA), P-selectin gene (SELP) polymorphisms, and HPA and SELP haplotypes with factor V (FV) R506Q in ischemic pediatric stroke (IPS) subtypes: cerebral sinovenous thrombosis (CSVT), perinatal (PAIS), and childhood (CAIS) arterial ischemic stroke.
This case-control study enrolled 150 children with confirmed IPS and 150 age- and sex-matched controls. FV R506Q and HPA-1 were genotyped with CVD StripAssay®, HPA-2 and HPA-3 with real-time polymerase chain reaction, SELP S290N, V599L, and T715P with high resolution melting analysis, and SELP N562D with sequence-specific polymerase chain reaction.
HPA-1b allele (odds ratio [OR] 2.75, 95% confidence interval [CI] 1.02-7.42, P=0.048) and HPA-1a2a3b (OR 5.46, 95% CI 1.51-19.76, P=0.011), HPA-1b2a3a (OR 7.00, 95% CI 1.25-39.13, P=0.028), and HPA-1b2b3a (OR 11.39, 95% CI 1.39-92.95, P=0.024) haplotypes increased the risk for CSVT. HPA-3b allele was significantly associated with 2-fold lower risk for PAIS (OR 0.49, 95% CI 0.26-0.89, P=0.020) and CAIS (OR 0.47, 95% CI 0.26-0.86, P=0.014) and non-significantly associated with increased risk for CSVT (OR 6.43, 95% CI 0.83-50.00, P=0.022). HPA-1a2b3a haplotype was significantly associated with CAIS (OR 6.76, 95% CI 2.13-21.44, P=0.001). The inclusion of FV R506Q in SELP haplotype analysis increased the risk for PAIS 4-fold in QNDVT carriers (OR 8.14, 95% CI 0.93-71.33, P=0.060) compared with NDVT haplotype (OR 2.45, 95% CI 0.98-6.18, P=0.058), but the result was not significant.
Individual HPAs, and particularly HPA haplotypes, are involved in IPS subtypes pathogenesis. A possible risk-inducing synergistic effect of SELP haplotypes with FV R506Q is restricted to PAIS only.</description><issn>0353-9504</issn><issn>1332-8166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpVkc1r2zAYxkXpaLJs1x2Hjr3Y07flHQaltGuhMBjbWcjK68aNbHmSXch_X4VkoTnp5Xke_fTxIPSFkpJzJr-5_qVkhJFS0ZLqC7SkWS40VeoSLQmXvKglEQv0MaUXknNCqCu04IxSzSuxROZ38IBDi0dvJ_Aw4WcYAI_B7_oQx02X-oS7AXfJbaDvHB5h3dkp5ilNMWwBp7mZdiOk79hiZxMULgzZ8dmf17tP6ENrfYLPx3WF_t7f_bl9KJ5-_Xy8vXkqnGB6KnRDpGsFFXWjKKs1axrG1lprmxUuFKGNEwRUxUXVOCtr4JqBaoWoWcVEy1fox4E7zk0Pawf5DtabMXa9jTsTbGfOnaHbmOfwaiqiuJQ8A4oDYBOd3Z5tPCgpOsijYYJQyXL--nhgDP9mSJPp8x-B93aAMCfDuKp1LSXZo8tD1MWQUoT2RKfE7Fs0uUWzb9EoanIxK_T1_WNO8f-18Tc-nJp7</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Čeri, Andrea</creator><creator>Leniček Krleža, Jasna</creator><creator>Coen Herak, Désirée</creator><creator>Miloš, Marija</creator><creator>Pavić, Marina</creator><creator>Barišić, Nina</creator><creator>Đuranović, Vlasta</creator><creator>Zadro, Renata</creator><general>Medicinski fakultet Sveučilišta u Zagrebu, Medicinski fakultet Sveučilišta u Splitu, Medicinski fakultet Sveučilišta u Rijeci</general><general>Croatian Medical Schools</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>VP8</scope><scope>5PM</scope></search><sort><creationdate>20200201</creationdate><title>Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study</title><author>Čeri, Andrea ; Leniček Krleža, Jasna ; Coen Herak, Désirée ; Miloš, Marija ; Pavić, Marina ; Barišić, Nina ; Đuranović, Vlasta ; Zadro, Renata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-8b05cf4149b612982bb22d888a49b34601bc40e67347bca59e382e6f4492724f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Čeri, Andrea</creatorcontrib><creatorcontrib>Leniček Krleža, Jasna</creatorcontrib><creatorcontrib>Coen Herak, Désirée</creatorcontrib><creatorcontrib>Miloš, Marija</creatorcontrib><creatorcontrib>Pavić, Marina</creatorcontrib><creatorcontrib>Barišić, Nina</creatorcontrib><creatorcontrib>Đuranović, Vlasta</creatorcontrib><creatorcontrib>Zadro, Renata</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hrcak: Portal of scientific journals of Croatia</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Croatian medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Čeri, Andrea</au><au>Leniček Krleža, Jasna</au><au>Coen Herak, Désirée</au><au>Miloš, Marija</au><au>Pavić, Marina</au><au>Barišić, Nina</au><au>Đuranović, Vlasta</au><au>Zadro, Renata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study</atitle><jtitle>Croatian medical journal</jtitle><addtitle>Croat Med J</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>61</volume><issue>1</issue><spage>18</spage><epage>27</epage><pages>18-27</pages><issn>0353-9504</issn><eissn>1332-8166</eissn><coden>CMEJEN</coden><abstract>To assess the role of human platelet antigens (HPA), P-selectin gene (SELP) polymorphisms, and HPA and SELP haplotypes with factor V (FV) R506Q in ischemic pediatric stroke (IPS) subtypes: cerebral sinovenous thrombosis (CSVT), perinatal (PAIS), and childhood (CAIS) arterial ischemic stroke.
This case-control study enrolled 150 children with confirmed IPS and 150 age- and sex-matched controls. FV R506Q and HPA-1 were genotyped with CVD StripAssay®, HPA-2 and HPA-3 with real-time polymerase chain reaction, SELP S290N, V599L, and T715P with high resolution melting analysis, and SELP N562D with sequence-specific polymerase chain reaction.
HPA-1b allele (odds ratio [OR] 2.75, 95% confidence interval [CI] 1.02-7.42, P=0.048) and HPA-1a2a3b (OR 5.46, 95% CI 1.51-19.76, P=0.011), HPA-1b2a3a (OR 7.00, 95% CI 1.25-39.13, P=0.028), and HPA-1b2b3a (OR 11.39, 95% CI 1.39-92.95, P=0.024) haplotypes increased the risk for CSVT. HPA-3b allele was significantly associated with 2-fold lower risk for PAIS (OR 0.49, 95% CI 0.26-0.89, P=0.020) and CAIS (OR 0.47, 95% CI 0.26-0.86, P=0.014) and non-significantly associated with increased risk for CSVT (OR 6.43, 95% CI 0.83-50.00, P=0.022). HPA-1a2b3a haplotype was significantly associated with CAIS (OR 6.76, 95% CI 2.13-21.44, P=0.001). The inclusion of FV R506Q in SELP haplotype analysis increased the risk for PAIS 4-fold in QNDVT carriers (OR 8.14, 95% CI 0.93-71.33, P=0.060) compared with NDVT haplotype (OR 2.45, 95% CI 0.98-6.18, P=0.058), but the result was not significant.
Individual HPAs, and particularly HPA haplotypes, are involved in IPS subtypes pathogenesis. A possible risk-inducing synergistic effect of SELP haplotypes with FV R506Q is restricted to PAIS only.</abstract><cop>Croatia</cop><pub>Medicinski fakultet Sveučilišta u Zagrebu, Medicinski fakultet Sveučilišta u Splitu, Medicinski fakultet Sveučilišta u Rijeci</pub><pmid>32118374</pmid><doi>10.3325/cmj.2020.61.18</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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title | Role of platelet gene polymorphisms in ischemic pediatric stroke subtypes: a case-control study |
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