Bone‐strengthening effects and safety of compound peptides from skin of Chiloscyllium plagiosum and Mustelus griseus
Fish processing produces a lot of by‐products highly containing large amount of proteins which mainly consist of collagen, implying great potential value for application as nutraceutical ingredients. In present study, two kinds of sharks, Chiloscyllium plagiosum and Mustelus griseus, were used as ra...
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| Veröffentlicht in: | Food Science & Nutrition 2020-03, Vol.8 (3), p.1522-1533 |
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| creator | Xu, Xin‐Heng Lv, Peng‐Fei Wang, Tong‐Xin Wang, Bao‐Xuan Shi, Yan Wang, Bi‐Xue Meng, Zheng‐Rou Chen, Qing‐Xi Zhuang, Jiang‐Xing Wang, Yule‐Yue |
| description | Fish processing produces a lot of by‐products highly containing large amount of proteins which mainly consist of collagen, implying great potential value for application as nutraceutical ingredients. In present study, two kinds of sharks, Chiloscyllium plagiosum and Mustelus griseus, were used as raw material to gain three kinds of “compound peptides” (CPs) by enzymolysis, FCP (CPs from the flesh of C. plagiosum), SCP (CPs from the skin of C. plagiosum), and SMG (CPs from the skin of M. griseus). According to a series of constituent analysis, the molecule weights of FCP, SCP, and SMG were under 800 Da; amino acids composition analysis of FCP, SCP, and SMG showed that there were high glycine, proline, and hydroxyproline and low cysteine contents in SCP and SMG, which is the characteristic of collagen peptides; their total protein contents were 87.500%, 91.875%, and 95.625%, respectively; and heavy metal contents of CPs were all beneath national standards. After three kinds of CPs were administrated intragastrically to C57BL/6 mice at a total dosage of 15 g/kg, bone‐strengthening effects of SCP and SMG were manifested by osteoblasts activity promotion, bone mineral density (BMD) increase, and marrow adipocyte number decrease, yet nonsignificant effects were shown in FCP group. No index showed toxicity of SCP and SMG in subacute toxicology trial, indicating their safety as functional foods. Herein, industrial application foundation of the skins from these two sharks was explored but more efforts should subsequently be implemented for further exploitation.
Our research showed that the skin of two kinds of sharks Chiloscyllium plagiosum and Mustelus griseus might have a novel application as extractive raw materials of functional food—a hydrolysate which we named compound peptides. They are easy to produce and possess bone‐strengthening effects and nontoxic, laying a foundation for industrial production. |
| doi_str_mv | 10.1002/fsn3.1438 |
| format | Article |
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Our research showed that the skin of two kinds of sharks Chiloscyllium plagiosum and Mustelus griseus might have a novel application as extractive raw materials of functional food—a hydrolysate which we named compound peptides. They are easy to produce and possess bone‐strengthening effects and nontoxic, laying a foundation for industrial production.</description><identifier>ISSN: 2048-7177</identifier><identifier>EISSN: 2048-7177</identifier><identifier>DOI: 10.1002/fsn3.1438</identifier><identifier>PMID: 32180961</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Amino acids ; Aqueous solutions ; Arthritis ; Biomedical materials ; Bone marrow ; Bone mineral density ; bone trabecular ; Bones ; bone‐strengthening effects ; Chiloscyllium plagiosum ; Collagen ; compound peptides ; Density ; Enzymolysis ; Food ; Food industry ; Food safety ; Functional foods ; Functional foods & nutraceuticals ; Glycine ; Heavy metals ; Hydrochloric acid ; Hydroxyproline ; Industrial applications ; Laboratory animals ; Metabolism ; Mustelus griseus ; Original Research ; Osteoblasts ; Peptides ; Proline ; Proteins ; Raw materials ; Safety and security measures ; shark skin ; Sharks ; Skin ; subacute toxicity ; Toxicity ; Toxicology ; Zoonoses</subject><ispartof>Food Science & Nutrition, 2020-03, Vol.8 (3), p.1522-1533</ispartof><rights>2020 The Authors. published by Wiley Periodicals, Inc.</rights><rights>2020 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5108-55aa337e902459066324a0ef52dfc418c3d79532ecb055aca875f790710968ad3</citedby><cites>FETCH-LOGICAL-c5108-55aa337e902459066324a0ef52dfc418c3d79532ecb055aca875f790710968ad3</cites><orcidid>0000-0002-3951-8873 ; 0000-0002-8775-1506 ; 0000-0003-0914-5719 ; 0000-0002-1024-7344</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063341/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063341/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32180961$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xin‐Heng</creatorcontrib><creatorcontrib>Lv, Peng‐Fei</creatorcontrib><creatorcontrib>Wang, Tong‐Xin</creatorcontrib><creatorcontrib>Wang, Bao‐Xuan</creatorcontrib><creatorcontrib>Shi, Yan</creatorcontrib><creatorcontrib>Wang, Bi‐Xue</creatorcontrib><creatorcontrib>Meng, Zheng‐Rou</creatorcontrib><creatorcontrib>Chen, Qing‐Xi</creatorcontrib><creatorcontrib>Zhuang, Jiang‐Xing</creatorcontrib><creatorcontrib>Wang, Yule‐Yue</creatorcontrib><title>Bone‐strengthening effects and safety of compound peptides from skin of Chiloscyllium plagiosum and Mustelus griseus</title><title>Food Science & Nutrition</title><addtitle>Food Sci Nutr</addtitle><description>Fish processing produces a lot of by‐products highly containing large amount of proteins which mainly consist of collagen, implying great potential value for application as nutraceutical ingredients. In present study, two kinds of sharks, Chiloscyllium plagiosum and Mustelus griseus, were used as raw material to gain three kinds of “compound peptides” (CPs) by enzymolysis, FCP (CPs from the flesh of C. plagiosum), SCP (CPs from the skin of C. plagiosum), and SMG (CPs from the skin of M. griseus). According to a series of constituent analysis, the molecule weights of FCP, SCP, and SMG were under 800 Da; amino acids composition analysis of FCP, SCP, and SMG showed that there were high glycine, proline, and hydroxyproline and low cysteine contents in SCP and SMG, which is the characteristic of collagen peptides; their total protein contents were 87.500%, 91.875%, and 95.625%, respectively; and heavy metal contents of CPs were all beneath national standards. After three kinds of CPs were administrated intragastrically to C57BL/6 mice at a total dosage of 15 g/kg, bone‐strengthening effects of SCP and SMG were manifested by osteoblasts activity promotion, bone mineral density (BMD) increase, and marrow adipocyte number decrease, yet nonsignificant effects were shown in FCP group. No index showed toxicity of SCP and SMG in subacute toxicology trial, indicating their safety as functional foods. Herein, industrial application foundation of the skins from these two sharks was explored but more efforts should subsequently be implemented for further exploitation.
Our research showed that the skin of two kinds of sharks Chiloscyllium plagiosum and Mustelus griseus might have a novel application as extractive raw materials of functional food—a hydrolysate which we named compound peptides. They are easy to produce and possess bone‐strengthening effects and nontoxic, laying a foundation for industrial production.</description><subject>Amino acids</subject><subject>Aqueous solutions</subject><subject>Arthritis</subject><subject>Biomedical materials</subject><subject>Bone marrow</subject><subject>Bone mineral density</subject><subject>bone trabecular</subject><subject>Bones</subject><subject>bone‐strengthening effects</subject><subject>Chiloscyllium plagiosum</subject><subject>Collagen</subject><subject>compound peptides</subject><subject>Density</subject><subject>Enzymolysis</subject><subject>Food</subject><subject>Food industry</subject><subject>Food safety</subject><subject>Functional foods</subject><subject>Functional foods & nutraceuticals</subject><subject>Glycine</subject><subject>Heavy metals</subject><subject>Hydrochloric acid</subject><subject>Hydroxyproline</subject><subject>Industrial applications</subject><subject>Laboratory animals</subject><subject>Metabolism</subject><subject>Mustelus griseus</subject><subject>Original Research</subject><subject>Osteoblasts</subject><subject>Peptides</subject><subject>Proline</subject><subject>Proteins</subject><subject>Raw materials</subject><subject>Safety and security measures</subject><subject>shark skin</subject><subject>Sharks</subject><subject>Skin</subject><subject>subacute 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effects and safety of compound peptides from skin of Chiloscyllium plagiosum and Mustelus griseus</title><author>Xu, Xin‐Heng ; Lv, Peng‐Fei ; Wang, Tong‐Xin ; Wang, Bao‐Xuan ; Shi, Yan ; Wang, Bi‐Xue ; Meng, Zheng‐Rou ; Chen, Qing‐Xi ; Zhuang, Jiang‐Xing ; Wang, Yule‐Yue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5108-55aa337e902459066324a0ef52dfc418c3d79532ecb055aca875f790710968ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Amino acids</topic><topic>Aqueous solutions</topic><topic>Arthritis</topic><topic>Biomedical materials</topic><topic>Bone marrow</topic><topic>Bone mineral density</topic><topic>bone trabecular</topic><topic>Bones</topic><topic>bone‐strengthening effects</topic><topic>Chiloscyllium plagiosum</topic><topic>Collagen</topic><topic>compound peptides</topic><topic>Density</topic><topic>Enzymolysis</topic><topic>Food</topic><topic>Food 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Qing‐Xi</au><au>Zhuang, Jiang‐Xing</au><au>Wang, Yule‐Yue</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone‐strengthening effects and safety of compound peptides from skin of Chiloscyllium plagiosum and Mustelus griseus</atitle><jtitle>Food Science & Nutrition</jtitle><addtitle>Food Sci Nutr</addtitle><date>2020-03</date><risdate>2020</risdate><volume>8</volume><issue>3</issue><spage>1522</spage><epage>1533</epage><pages>1522-1533</pages><issn>2048-7177</issn><eissn>2048-7177</eissn><abstract>Fish processing produces a lot of by‐products highly containing large amount of proteins which mainly consist of collagen, implying great potential value for application as nutraceutical ingredients. In present study, two kinds of sharks, Chiloscyllium plagiosum and Mustelus griseus, were used as raw material to gain three kinds of “compound peptides” (CPs) by enzymolysis, FCP (CPs from the flesh of C. plagiosum), SCP (CPs from the skin of C. plagiosum), and SMG (CPs from the skin of M. griseus). According to a series of constituent analysis, the molecule weights of FCP, SCP, and SMG were under 800 Da; amino acids composition analysis of FCP, SCP, and SMG showed that there were high glycine, proline, and hydroxyproline and low cysteine contents in SCP and SMG, which is the characteristic of collagen peptides; their total protein contents were 87.500%, 91.875%, and 95.625%, respectively; and heavy metal contents of CPs were all beneath national standards. After three kinds of CPs were administrated intragastrically to C57BL/6 mice at a total dosage of 15 g/kg, bone‐strengthening effects of SCP and SMG were manifested by osteoblasts activity promotion, bone mineral density (BMD) increase, and marrow adipocyte number decrease, yet nonsignificant effects were shown in FCP group. No index showed toxicity of SCP and SMG in subacute toxicology trial, indicating their safety as functional foods. Herein, industrial application foundation of the skins from these two sharks was explored but more efforts should subsequently be implemented for further exploitation.
Our research showed that the skin of two kinds of sharks Chiloscyllium plagiosum and Mustelus griseus might have a novel application as extractive raw materials of functional food—a hydrolysate which we named compound peptides. They are easy to produce and possess bone‐strengthening effects and nontoxic, laying a foundation for industrial production.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>32180961</pmid><doi>10.1002/fsn3.1438</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3951-8873</orcidid><orcidid>https://orcid.org/0000-0002-8775-1506</orcidid><orcidid>https://orcid.org/0000-0003-0914-5719</orcidid><orcidid>https://orcid.org/0000-0002-1024-7344</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Amino acids Aqueous solutions Arthritis Biomedical materials Bone marrow Bone mineral density bone trabecular Bones bone‐strengthening effects Chiloscyllium plagiosum Collagen compound peptides Density Enzymolysis Food Food industry Food safety Functional foods Functional foods & nutraceuticals Glycine Heavy metals Hydrochloric acid Hydroxyproline Industrial applications Laboratory animals Metabolism Mustelus griseus Original Research Osteoblasts Peptides Proline Proteins Raw materials Safety and security measures shark skin Sharks Skin subacute toxicity Toxicity Toxicology Zoonoses |
| title | Bone‐strengthening effects and safety of compound peptides from skin of Chiloscyllium plagiosum and Mustelus griseus |
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