Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement
Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both in vitro and in vi...
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| Veröffentlicht in: | Scientific reports 2020-03, Vol.10 (1), p.4338, Article 4338 |
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| description | Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both
in vitro
and
in vivo
models, while increasing the hair growth efficacy compared to single-frequency US sonication. The
in vitro
experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in
in vitro
Franz-diffusion-cell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dual-frequency US-mediated MB cavitation can significantly increase both skin permeability and transdermal drug delivery. At the same US power density, hair growth was greater in the group with dual-frequency US plus MBs than in the group with single-frequency US plus MBs, without damaging the skin in mice. |
| doi_str_mv | 10.1038/s41598-020-61328-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7062896</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2375481191</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-3dbbb560ab421ca40ab6da96977c585bc2e9b8d25f9b1dd0c64cd28e3e0243233</originalsourceid><addsrcrecordid>eNp9UctuFDEQtFAQiUJ-gAOyxHkSu23PjC9IKAok0kpc4Gz5NbuOZuxgz2zYH-C7MWwem0t8cVldXdXuQugDJeeUsP6icCpk3xAgTUsZVPQGnQDhogEGcHSAj9FZKbekHgGSU_kOHTOgAjhlJ-jPKt03Q_a_Fh_tDrtFjwfPZZyzLmmJrpm8C3r2Dk_B5mQWY0aPrd6GWc8hRTykjCs5FufzpMdKi-l3cGHEzo9h6_MO6-jwRoeM1zndzxvs40ZH6ycf5_fo7aDH4s8e7lP08-vVj8vrZvX9283ll1VjecfnhjljjGiJNhyo1byC1mnZyq6zohfGgpemdyAGaahzxLbcOug98wQ4A8ZO0ee97t1i6o9stc56VHc5TDrvVNJBvazEsFHrtFUdaaGXbRX49CCQU11SmdVtWnKsMytgneA9pZJWFuxZdVWlZD88OVCi_sWn9vGpGp_6H58itenj4WxPLY9hVQLbE0otxbXPz96vyP4FRrmq2A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2375481191</pqid></control><display><type>article</type><title>Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Liao, Ai-Ho ; Lin, Keng-Hsien ; Chuang, Ho-Chiao ; Tsai, Chih-Hung ; Lin, Yi-Chun ; Wang, Chih-Hung ; Shih, Cheng-Ping ; Liu, Hao-Li</creator><creatorcontrib>Liao, Ai-Ho ; Lin, Keng-Hsien ; Chuang, Ho-Chiao ; Tsai, Chih-Hung ; Lin, Yi-Chun ; Wang, Chih-Hung ; Shih, Cheng-Ping ; Liu, Hao-Li</creatorcontrib><description>Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both
in vitro
and
in vivo
models, while increasing the hair growth efficacy compared to single-frequency US sonication. The
in vitro
experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in
in vitro
Franz-diffusion-cell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dual-frequency US-mediated MB cavitation can significantly increase both skin permeability and transdermal drug delivery. At the same US power density, hair growth was greater in the group with dual-frequency US plus MBs than in the group with single-frequency US plus MBs, without damaging the skin in mice.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-61328-0</identifier><identifier>PMID: 32152413</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/57 ; 692/308 ; Administration, Cutaneous ; Animals ; Cavitation ; Drug delivery ; Drug Delivery Systems - methods ; Drug Delivery Systems - standards ; Experiments ; Follicles ; Growth rate ; Hair ; Hair - drug effects ; Hair - growth & development ; Hair Follicle - drug effects ; Humanities and Social Sciences ; Mice ; Microbubbles ; Minoxidil ; Minoxidil - administration & dosage ; Minoxidil - pharmacokinetics ; Models, Animal ; Models, Biological ; multidisciplinary ; Permeability ; Science ; Science (multidisciplinary) ; Sonication ; Transdermal medication ; Ultrasonic imaging ; Ultrasonic Waves ; Ultrasound</subject><ispartof>Scientific reports, 2020-03, Vol.10 (1), p.4338, Article 4338</ispartof><rights>The Author(s) 2020</rights><rights>This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-3dbbb560ab421ca40ab6da96977c585bc2e9b8d25f9b1dd0c64cd28e3e0243233</citedby><cites>FETCH-LOGICAL-c474t-3dbbb560ab421ca40ab6da96977c585bc2e9b8d25f9b1dd0c64cd28e3e0243233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062896/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062896/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,41118,42187,51574,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32152413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Ai-Ho</creatorcontrib><creatorcontrib>Lin, Keng-Hsien</creatorcontrib><creatorcontrib>Chuang, Ho-Chiao</creatorcontrib><creatorcontrib>Tsai, Chih-Hung</creatorcontrib><creatorcontrib>Lin, Yi-Chun</creatorcontrib><creatorcontrib>Wang, Chih-Hung</creatorcontrib><creatorcontrib>Shih, Cheng-Ping</creatorcontrib><creatorcontrib>Liu, Hao-Li</creatorcontrib><title>Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both
in vitro
and
in vivo
models, while increasing the hair growth efficacy compared to single-frequency US sonication. The
in vitro
experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in
in vitro
Franz-diffusion-cell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dual-frequency US-mediated MB cavitation can significantly increase both skin permeability and transdermal drug delivery. At the same US power density, hair growth was greater in the group with dual-frequency US plus MBs than in the group with single-frequency US plus MBs, without damaging the skin in mice.</description><subject>631/57</subject><subject>692/308</subject><subject>Administration, Cutaneous</subject><subject>Animals</subject><subject>Cavitation</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Delivery Systems - standards</subject><subject>Experiments</subject><subject>Follicles</subject><subject>Growth rate</subject><subject>Hair</subject><subject>Hair - drug effects</subject><subject>Hair - growth & development</subject><subject>Hair Follicle - drug effects</subject><subject>Humanities and Social Sciences</subject><subject>Mice</subject><subject>Microbubbles</subject><subject>Minoxidil</subject><subject>Minoxidil - administration & dosage</subject><subject>Minoxidil - pharmacokinetics</subject><subject>Models, Animal</subject><subject>Models, Biological</subject><subject>multidisciplinary</subject><subject>Permeability</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Sonication</subject><subject>Transdermal medication</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonic Waves</subject><subject>Ultrasound</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9UctuFDEQtFAQiUJ-gAOyxHkSu23PjC9IKAok0kpc4Gz5NbuOZuxgz2zYH-C7MWwem0t8cVldXdXuQugDJeeUsP6icCpk3xAgTUsZVPQGnQDhogEGcHSAj9FZKbekHgGSU_kOHTOgAjhlJ-jPKt03Q_a_Fh_tDrtFjwfPZZyzLmmJrpm8C3r2Dk_B5mQWY0aPrd6GWc8hRTykjCs5FufzpMdKi-l3cGHEzo9h6_MO6-jwRoeM1zndzxvs40ZH6ycf5_fo7aDH4s8e7lP08-vVj8vrZvX9283ll1VjecfnhjljjGiJNhyo1byC1mnZyq6zohfGgpemdyAGaahzxLbcOug98wQ4A8ZO0ee97t1i6o9stc56VHc5TDrvVNJBvazEsFHrtFUdaaGXbRX49CCQU11SmdVtWnKsMytgneA9pZJWFuxZdVWlZD88OVCi_sWn9vGpGp_6H58itenj4WxPLY9hVQLbE0otxbXPz96vyP4FRrmq2A</recordid><startdate>20200309</startdate><enddate>20200309</enddate><creator>Liao, Ai-Ho</creator><creator>Lin, Keng-Hsien</creator><creator>Chuang, Ho-Chiao</creator><creator>Tsai, Chih-Hung</creator><creator>Lin, Yi-Chun</creator><creator>Wang, Chih-Hung</creator><creator>Shih, Cheng-Ping</creator><creator>Liu, Hao-Li</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20200309</creationdate><title>Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement</title><author>Liao, Ai-Ho ; Lin, Keng-Hsien ; Chuang, Ho-Chiao ; Tsai, Chih-Hung ; Lin, Yi-Chun ; Wang, Chih-Hung ; Shih, Cheng-Ping ; Liu, Hao-Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-3dbbb560ab421ca40ab6da96977c585bc2e9b8d25f9b1dd0c64cd28e3e0243233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>631/57</topic><topic>692/308</topic><topic>Administration, Cutaneous</topic><topic>Animals</topic><topic>Cavitation</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Delivery Systems - standards</topic><topic>Experiments</topic><topic>Follicles</topic><topic>Growth rate</topic><topic>Hair</topic><topic>Hair - drug effects</topic><topic>Hair - growth & development</topic><topic>Hair Follicle - drug effects</topic><topic>Humanities and Social Sciences</topic><topic>Mice</topic><topic>Microbubbles</topic><topic>Minoxidil</topic><topic>Minoxidil - administration & dosage</topic><topic>Minoxidil - pharmacokinetics</topic><topic>Models, Animal</topic><topic>Models, Biological</topic><topic>multidisciplinary</topic><topic>Permeability</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Sonication</topic><topic>Transdermal medication</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonic Waves</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Ai-Ho</creatorcontrib><creatorcontrib>Lin, Keng-Hsien</creatorcontrib><creatorcontrib>Chuang, Ho-Chiao</creatorcontrib><creatorcontrib>Tsai, Chih-Hung</creatorcontrib><creatorcontrib>Lin, Yi-Chun</creatorcontrib><creatorcontrib>Wang, Chih-Hung</creatorcontrib><creatorcontrib>Shih, Cheng-Ping</creatorcontrib><creatorcontrib>Liu, Hao-Li</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Ai-Ho</au><au>Lin, Keng-Hsien</au><au>Chuang, Ho-Chiao</au><au>Tsai, Chih-Hung</au><au>Lin, Yi-Chun</au><au>Wang, Chih-Hung</au><au>Shih, Cheng-Ping</au><au>Liu, Hao-Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-03-09</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>4338</spage><pages>4338-</pages><artnum>4338</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Ultrasound (US) has been found to rejuvenate and invigorate the hair follicles, increase the size of hair shafts, and promote new hair growth. Our present study found that dual-frequency US-mediated microbubble (MB) cavitation significantly enhanced minoxidil (Mx) delivery in both
in vitro
and
in vivo
models, while increasing the hair growth efficacy compared to single-frequency US sonication. The
in vitro
experiments showed that cavitation activity was enhanced more significantly during dual-frequency sonication than single-frequency sonication in higher concentration of MBs. The pigskin penetration depth in the group in which dual-frequency US was combined with MBs was 1.54 and 2.86 times greater than for single-frequency US combined with MBs and in the control group, respectively; the corresponding increases in the release rate of Mx at 18 hours in
in vitro
Franz-diffusion-cell experiments were 24.9% and 43.7%. During 21 days of treatment in C57BL/6J mice experiments, the growth rate at day 11 in the group in which dual-frequency US was combined with MBs increased by 2.07 times compared to single-frequency US combined with MBs. These results indicate that dual-frequency US-mediated MB cavitation can significantly increase both skin permeability and transdermal drug delivery. At the same US power density, hair growth was greater in the group with dual-frequency US plus MBs than in the group with single-frequency US plus MBs, without damaging the skin in mice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32152413</pmid><doi>10.1038/s41598-020-61328-0</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 631/57 692/308 Administration, Cutaneous Animals Cavitation Drug delivery Drug Delivery Systems - methods Drug Delivery Systems - standards Experiments Follicles Growth rate Hair Hair - drug effects Hair - growth & development Hair Follicle - drug effects Humanities and Social Sciences Mice Microbubbles Minoxidil Minoxidil - administration & dosage Minoxidil - pharmacokinetics Models, Animal Models, Biological multidisciplinary Permeability Science Science (multidisciplinary) Sonication Transdermal medication Ultrasonic imaging Ultrasonic Waves Ultrasound |
| title | Low-frequency dual-frequency ultrasound-mediated microbubble cavitation for transdermal minoxidil delivery and hair growth enhancement |
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