Mechanism underlying autoinducer recognition in the Vibrio cholerae DPO-VqmA quorum-sensing pathway

Quorum sensing is a bacterial communication process whereby bacteria produce, release, and detect extracellular signaling molecules called autoinducers to coordinate collective behaviors. In the pathogen Vibrio cholerae, the quorum-sensing autoinducer 3,5-dimethyl-pyrazin-2-ol (DPO) binds the recept...

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Veröffentlicht in:	The Journal of biological chemistry 2020-03, Vol.295 (10), p.2916-2931
Hauptverfasser:	Huang, Xiuliang, Duddy, Olivia P., Silpe, Justin E., Paczkowski, Jon E., Cong, Jianping, Henke, Brad R., Bassler, Bonnie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,5-dimethyl-pyrazin-2-ol (DPO) autoinducer bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism binding Binding Sites crystallography Crystallography, X-Ray DNA - chemistry DNA - metabolism Gene Expression Regulation, Bacterial gene regulation Ligands Microbiology Molecular Dynamics Simulation Mutagenesis, Site-Directed N-alanyl-aminoacetone (Ala-AA) Protein Binding Pyrazoles - chemistry Pyrazoles - metabolism Quorum Sensing Signal Transduction Structure-Activity Relationship Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Vibrio cholerae Vibrio cholerae - metabolism VqmA
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