Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy
Purpose To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR). Methods Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] an...
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| Veröffentlicht in: | Acta ophthalmologica (Oxford, England) England), 2020-03, Vol.98 (2), p.e224-e231 |
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| container_title | Acta ophthalmologica (Oxford, England) |
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| creator | McAnany, J. Jason Park, Jason C. Liu, Karen Liu, Michelle Chen, Yi‐Fan Chau, Felix Y. Lim, Jennifer I. |
| description | Purpose
To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR).
Methods
Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] and 20 had mild non‐proliferative DR [NPDR]). No subject had a history of treatment for macular oedema. Letter CS, microperimetry (MP) sensitivity and visual acuity (VA) were measured. Letter CS and MP measurements were performed over the central 6° of the visual field. Spectral domain optical coherence tomography (SD‐OCT) images were obtained at corresponding locations, outer‐retina thickness was quantified, and structure–function relationships were evaluated.
Results
Analysis of variance indicated significant letter CS differences among the groups (p |
| doi_str_mv | 10.1111/aos.14241 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7060819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2371529672</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4431-fe424b51dfd405516b3ce0b1aeaf10e97a8ef68e509e9a55de59c9fb21742b473</originalsourceid><addsrcrecordid>eNp1kc9KHTEUh4NU1FoXvkAJdGMXV5OZ_JnZFORS24LgogrdhUzmjDd27uSak1Fm10fwGfskjV570UKzOYHz8XF-_Ag55OyY53diAx5zUQi-Rfa4lnJWalW92fzlj13yFvGGMcWVEjtkt-SSayH0HunmYUjRYqIIA_rk73yaqEdqEYPzNkFL731a0DAmiL9_PURIfrA0Lbz7OQAi9QMFG_sp7zDZa6Ctt02GHH1Cw8qmxfSObHe2Rzh4nvvk6uzz5fzr7Pziy7f56fnMCVHyWQc5RSN527WCSclVUzpgDbdgO86g1raCTlUgWQ21lbIFWbu6a4qcpmiELvfJp7V3NTZLaB08huvNKvqljZMJ1pvXm8EvzHW4M5opVvE6C46eBTHcjoDJLD066Hs7QBjRFEXNqrJSZZXRD_-gN2GMQ45nilJzWdRKF5n6uKZcDIgRus0xnJnH9kxuzzy1l9n3L6_fkH_rysDJGrj3PUz_N5nTi-9r5R_mMKkj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2371529672</pqid></control><display><type>article</type><title>Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy</title><source>MEDLINE</source><source>Wiley Journals</source><source>Wiley Online Library (Open Access Collection)</source><creator>McAnany, J. Jason ; Park, Jason C. ; Liu, Karen ; Liu, Michelle ; Chen, Yi‐Fan ; Chau, Felix Y. ; Lim, Jennifer I.</creator><creatorcontrib>McAnany, J. Jason ; Park, Jason C. ; Liu, Karen ; Liu, Michelle ; Chen, Yi‐Fan ; Chau, Felix Y. ; Lim, Jennifer I.</creatorcontrib><description>Purpose
To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR).
Methods
Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] and 20 had mild non‐proliferative DR [NPDR]). No subject had a history of treatment for macular oedema. Letter CS, microperimetry (MP) sensitivity and visual acuity (VA) were measured. Letter CS and MP measurements were performed over the central 6° of the visual field. Spectral domain optical coherence tomography (SD‐OCT) images were obtained at corresponding locations, outer‐retina thickness was quantified, and structure–function relationships were evaluated.
Results
Analysis of variance indicated significant letter CS differences among the groups (p < 0.001). Letter CS was reduced significantly for the mild NPDR group (p < 0.001; 33% reduction), but not the NDR group (p = 0.08). There were no significant differences in MP sensitivity or ORT among the groups (both p > 0.10). Nevertheless, Hoeffding's D tests indicated significant associations between ORT and letter CS (p < 0.001) and between ORT and MP sensitivity for the mild NPDR group (p = 0.01). VA was not significantly associated with ORT for either diabetic group (both p > 0.49).
Conclusions
Outer‐retina thickness is associated with letter CS and MP sensitivity, but not VA, in mild NPDR. This finding highlights the usefulness of simple letter CS measures and suggests neural dysfunction can occur in the absence of marked structural abnormalities in early‐stage DR.</description><identifier>ISSN: 1755-375X</identifier><identifier>EISSN: 1755-3768</identifier><identifier>DOI: 10.1111/aos.14241</identifier><identifier>PMID: 31517447</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Acuity ; Adult ; contrast sensitivity ; Contrast Sensitivity - physiology ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetic retinopathy ; Diabetic Retinopathy - physiopathology ; Edema ; Female ; Humans ; Male ; microperimetry ; Middle Aged ; optical coherence tomography ; Organ Size ; Retina ; Retina - pathology ; Retinopathy ; Structure-function relationships ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Visual field ; Visual Field Tests ; Visual Fields - physiology</subject><ispartof>Acta ophthalmologica (Oxford, England), 2020-03, Vol.98 (2), p.e224-e231</ispartof><rights>2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd</rights><rights>2019 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 Acta Ophthalmologica Scandinavica Foundation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-fe424b51dfd405516b3ce0b1aeaf10e97a8ef68e509e9a55de59c9fb21742b473</citedby><cites>FETCH-LOGICAL-c4431-fe424b51dfd405516b3ce0b1aeaf10e97a8ef68e509e9a55de59c9fb21742b473</cites><orcidid>0000-0003-1192-3487</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faos.14241$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faos.14241$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31517447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McAnany, J. Jason</creatorcontrib><creatorcontrib>Park, Jason C.</creatorcontrib><creatorcontrib>Liu, Karen</creatorcontrib><creatorcontrib>Liu, Michelle</creatorcontrib><creatorcontrib>Chen, Yi‐Fan</creatorcontrib><creatorcontrib>Chau, Felix Y.</creatorcontrib><creatorcontrib>Lim, Jennifer I.</creatorcontrib><title>Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy</title><title>Acta ophthalmologica (Oxford, England)</title><addtitle>Acta Ophthalmol</addtitle><description>Purpose
To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR).
Methods
Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] and 20 had mild non‐proliferative DR [NPDR]). No subject had a history of treatment for macular oedema. Letter CS, microperimetry (MP) sensitivity and visual acuity (VA) were measured. Letter CS and MP measurements were performed over the central 6° of the visual field. Spectral domain optical coherence tomography (SD‐OCT) images were obtained at corresponding locations, outer‐retina thickness was quantified, and structure–function relationships were evaluated.
Results
Analysis of variance indicated significant letter CS differences among the groups (p < 0.001). Letter CS was reduced significantly for the mild NPDR group (p < 0.001; 33% reduction), but not the NDR group (p = 0.08). There were no significant differences in MP sensitivity or ORT among the groups (both p > 0.10). Nevertheless, Hoeffding's D tests indicated significant associations between ORT and letter CS (p < 0.001) and between ORT and MP sensitivity for the mild NPDR group (p = 0.01). VA was not significantly associated with ORT for either diabetic group (both p > 0.49).
Conclusions
Outer‐retina thickness is associated with letter CS and MP sensitivity, but not VA, in mild NPDR. This finding highlights the usefulness of simple letter CS measures and suggests neural dysfunction can occur in the absence of marked structural abnormalities in early‐stage DR.</description><subject>Acuity</subject><subject>Adult</subject><subject>contrast sensitivity</subject><subject>Contrast Sensitivity - physiology</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - physiopathology</subject><subject>Edema</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>microperimetry</subject><subject>Middle Aged</subject><subject>optical coherence tomography</subject><subject>Organ Size</subject><subject>Retina</subject><subject>Retina - pathology</subject><subject>Retinopathy</subject><subject>Structure-function relationships</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Visual field</subject><subject>Visual Field Tests</subject><subject>Visual Fields - physiology</subject><issn>1755-375X</issn><issn>1755-3768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9KHTEUh4NU1FoXvkAJdGMXV5OZ_JnZFORS24LgogrdhUzmjDd27uSak1Fm10fwGfskjV570UKzOYHz8XF-_Ag55OyY53diAx5zUQi-Rfa4lnJWalW92fzlj13yFvGGMcWVEjtkt-SSayH0HunmYUjRYqIIA_rk73yaqEdqEYPzNkFL731a0DAmiL9_PURIfrA0Lbz7OQAi9QMFG_sp7zDZa6Ctt02GHH1Cw8qmxfSObHe2Rzh4nvvk6uzz5fzr7Pziy7f56fnMCVHyWQc5RSN527WCSclVUzpgDbdgO86g1raCTlUgWQ21lbIFWbu6a4qcpmiELvfJp7V3NTZLaB08huvNKvqljZMJ1pvXm8EvzHW4M5opVvE6C46eBTHcjoDJLD066Hs7QBjRFEXNqrJSZZXRD_-gN2GMQ45nilJzWdRKF5n6uKZcDIgRus0xnJnH9kxuzzy1l9n3L6_fkH_rysDJGrj3PUz_N5nTi-9r5R_mMKkj</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>McAnany, J. Jason</creator><creator>Park, Jason C.</creator><creator>Liu, Karen</creator><creator>Liu, Michelle</creator><creator>Chen, Yi‐Fan</creator><creator>Chau, Felix Y.</creator><creator>Lim, Jennifer I.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1192-3487</orcidid></search><sort><creationdate>202003</creationdate><title>Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy</title><author>McAnany, J. Jason ; Park, Jason C. ; Liu, Karen ; Liu, Michelle ; Chen, Yi‐Fan ; Chau, Felix Y. ; Lim, Jennifer I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-fe424b51dfd405516b3ce0b1aeaf10e97a8ef68e509e9a55de59c9fb21742b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acuity</topic><topic>Adult</topic><topic>contrast sensitivity</topic><topic>Contrast Sensitivity - physiology</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - physiopathology</topic><topic>Edema</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>microperimetry</topic><topic>Middle Aged</topic><topic>optical coherence tomography</topic><topic>Organ Size</topic><topic>Retina</topic><topic>Retina - pathology</topic><topic>Retinopathy</topic><topic>Structure-function relationships</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual field</topic><topic>Visual Field Tests</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McAnany, J. Jason</creatorcontrib><creatorcontrib>Park, Jason C.</creatorcontrib><creatorcontrib>Liu, Karen</creatorcontrib><creatorcontrib>Liu, Michelle</creatorcontrib><creatorcontrib>Chen, Yi‐Fan</creatorcontrib><creatorcontrib>Chau, Felix Y.</creatorcontrib><creatorcontrib>Lim, Jennifer I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta ophthalmologica (Oxford, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McAnany, J. Jason</au><au>Park, Jason C.</au><au>Liu, Karen</au><au>Liu, Michelle</au><au>Chen, Yi‐Fan</au><au>Chau, Felix Y.</au><au>Lim, Jennifer I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy</atitle><jtitle>Acta ophthalmologica (Oxford, England)</jtitle><addtitle>Acta Ophthalmol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>98</volume><issue>2</issue><spage>e224</spage><epage>e231</epage><pages>e224-e231</pages><issn>1755-375X</issn><eissn>1755-3768</eissn><abstract>Purpose
To determine the relationship between contrast sensitivity (CS) and outer‐retina thickness (ORT) in diabetics who have minimal or no diabetic retinopathy (DR).
Methods
Twenty non‐diabetic control subjects and 40 type‐2 diabetic subjects participated (20 had no clinically apparent DR [NDR] and 20 had mild non‐proliferative DR [NPDR]). No subject had a history of treatment for macular oedema. Letter CS, microperimetry (MP) sensitivity and visual acuity (VA) were measured. Letter CS and MP measurements were performed over the central 6° of the visual field. Spectral domain optical coherence tomography (SD‐OCT) images were obtained at corresponding locations, outer‐retina thickness was quantified, and structure–function relationships were evaluated.
Results
Analysis of variance indicated significant letter CS differences among the groups (p < 0.001). Letter CS was reduced significantly for the mild NPDR group (p < 0.001; 33% reduction), but not the NDR group (p = 0.08). There were no significant differences in MP sensitivity or ORT among the groups (both p > 0.10). Nevertheless, Hoeffding's D tests indicated significant associations between ORT and letter CS (p < 0.001) and between ORT and MP sensitivity for the mild NPDR group (p = 0.01). VA was not significantly associated with ORT for either diabetic group (both p > 0.49).
Conclusions
Outer‐retina thickness is associated with letter CS and MP sensitivity, but not VA, in mild NPDR. This finding highlights the usefulness of simple letter CS measures and suggests neural dysfunction can occur in the absence of marked structural abnormalities in early‐stage DR.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31517447</pmid><doi>10.1111/aos.14241</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1192-3487</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acuity Adult contrast sensitivity Contrast Sensitivity - physiology Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetic retinopathy Diabetic Retinopathy - physiopathology Edema Female Humans Male microperimetry Middle Aged optical coherence tomography Organ Size Retina Retina - pathology Retinopathy Structure-function relationships Tomography, Optical Coherence Visual Acuity - physiology Visual field Visual Field Tests Visual Fields - physiology |
| title | Contrast sensitivity is associated with outer‐retina thickness in early‐stage diabetic retinopathy |
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