Influence of Hydroxyapatite Coating for the Prevention of Bone Mineral Density Loss and Bone Metabolism after Total Hip Arthroplasty: Assessment Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial
Background. Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evalua...
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| creator | Inaba, Yutaka Miyamae, Yushi Oba, Masatoshi Hyonmin, Choe Kobayashi, Naomi Tezuka, Taro Morita, Akira |
| description | Background. Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evaluate the effectiveness of HA-coated implants for preventing BMD loss and to determine the status of bone remodeling after total hip arthroplasty (THA), making comparisons with non-HA-coated implants. Methods. A total of 52 patients who underwent primary THA were randomly allocated to HA and non-HA groups. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at 1 week postoperation to form a baseline measurement, and then 24 weeks and 48 weeks after surgery. The relative change in BMD was evaluated for regions of interest (ROIs) based on the Gruen zone classifications. 18F-fluoride positron emission tomography (PET) was performed at 24 weeks postsurgery, and the maximum standardized uptake values (SUVmax) were evaluated in the proximal (HA-coated) and distal (non-HA-coated) areas in both groups. Results. There were significant differences in BMD loss in ROIs 3 and 6 (p=0.03), while no significant difference was observed in ROI 7 at either 24 or 48 weeks postsurgery. There was no significant correlation between PET uptake and BMD (24 or 48 weeks) in either group. Conclusion. The influence of a HA coating in terms of BMD preservation is limited. No significant correlation was found between BMD and SUVmax measured by PET, either with or without the use of a HA coating. |
| doi_str_mv | 10.1155/2020/4154290 |
| format | Article |
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Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evaluate the effectiveness of HA-coated implants for preventing BMD loss and to determine the status of bone remodeling after total hip arthroplasty (THA), making comparisons with non-HA-coated implants. Methods. A total of 52 patients who underwent primary THA were randomly allocated to HA and non-HA groups. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at 1 week postoperation to form a baseline measurement, and then 24 weeks and 48 weeks after surgery. The relative change in BMD was evaluated for regions of interest (ROIs) based on the Gruen zone classifications. 18F-fluoride positron emission tomography (PET) was performed at 24 weeks postsurgery, and the maximum standardized uptake values (SUVmax) were evaluated in the proximal (HA-coated) and distal (non-HA-coated) areas in both groups. Results. There were significant differences in BMD loss in ROIs 3 and 6 (p=0.03), while no significant difference was observed in ROI 7 at either 24 or 48 weeks postsurgery. There was no significant correlation between PET uptake and BMD (24 or 48 weeks) in either group. Conclusion. The influence of a HA coating in terms of BMD preservation is limited. No significant correlation was found between BMD and SUVmax measured by PET, either with or without the use of a HA coating.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/4154290</identifier><identifier>PMID: 32185203</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Biomedical materials ; Bone density ; Bone implants ; Bone mineral density ; Bone remodeling ; Bone turnover ; Clinical trials ; Coating ; Coatings ; Dual energy X-ray absorptiometry ; Emission analysis ; Evaluation ; Fluorides ; Fluorine isotopes ; Hip ; Hydroxyapatite ; Joint replacement surgery ; Joint surgery ; Metabolism ; Patient satisfaction ; Positron emission ; Positron emission tomography ; Prevention ; Prostheses ; Randomization ; Surgery ; Surgical implants ; Tomography ; Total hip arthroplasty ; Transplants & implants</subject><ispartof>BioMed research international, 2020-01, Vol.2020 (2020), p.1-9</ispartof><rights>Copyright © 2020 Taro Tezuka et al.</rights><rights>Copyright © 2020 Taro Tezuka et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Taro Tezuka et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-2419-0860</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060431/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060431/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids></links><search><contributor>Ogawa, Kazuma</contributor><contributor>Kazuma Ogawa</contributor><creatorcontrib>Inaba, Yutaka</creatorcontrib><creatorcontrib>Miyamae, Yushi</creatorcontrib><creatorcontrib>Oba, Masatoshi</creatorcontrib><creatorcontrib>Hyonmin, Choe</creatorcontrib><creatorcontrib>Kobayashi, Naomi</creatorcontrib><creatorcontrib>Tezuka, Taro</creatorcontrib><creatorcontrib>Morita, Akira</creatorcontrib><title>Influence of Hydroxyapatite Coating for the Prevention of Bone Mineral Density Loss and Bone Metabolism after Total Hip Arthroplasty: Assessment Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial</title><title>BioMed research international</title><description>Background. Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evaluate the effectiveness of HA-coated implants for preventing BMD loss and to determine the status of bone remodeling after total hip arthroplasty (THA), making comparisons with non-HA-coated implants. Methods. A total of 52 patients who underwent primary THA were randomly allocated to HA and non-HA groups. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at 1 week postoperation to form a baseline measurement, and then 24 weeks and 48 weeks after surgery. The relative change in BMD was evaluated for regions of interest (ROIs) based on the Gruen zone classifications. 18F-fluoride positron emission tomography (PET) was performed at 24 weeks postsurgery, and the maximum standardized uptake values (SUVmax) were evaluated in the proximal (HA-coated) and distal (non-HA-coated) areas in both groups. Results. There were significant differences in BMD loss in ROIs 3 and 6 (p=0.03), while no significant difference was observed in ROI 7 at either 24 or 48 weeks postsurgery. There was no significant correlation between PET uptake and BMD (24 or 48 weeks) in either group. Conclusion. The influence of a HA coating in terms of BMD preservation is limited. No significant correlation was found between BMD and SUVmax measured by PET, either with or without the use of a HA coating.</description><subject>Biomedical materials</subject><subject>Bone density</subject><subject>Bone implants</subject><subject>Bone mineral density</subject><subject>Bone remodeling</subject><subject>Bone turnover</subject><subject>Clinical trials</subject><subject>Coating</subject><subject>Coatings</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Emission analysis</subject><subject>Evaluation</subject><subject>Fluorides</subject><subject>Fluorine isotopes</subject><subject>Hip</subject><subject>Hydroxyapatite</subject><subject>Joint replacement surgery</subject><subject>Joint surgery</subject><subject>Metabolism</subject><subject>Patient satisfaction</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Prevention</subject><subject>Prostheses</subject><subject>Randomization</subject><subject>Surgery</subject><subject>Surgical implants</subject><subject>Tomography</subject><subject>Total hip arthroplasty</subject><subject>Transplants & 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of Hydroxyapatite Coating for the Prevention of Bone Mineral Density Loss and Bone Metabolism after Total Hip Arthroplasty: Assessment Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial</title><author>Inaba, Yutaka ; Miyamae, Yushi ; Oba, Masatoshi ; Hyonmin, Choe ; Kobayashi, Naomi ; Tezuka, Taro ; Morita, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e2130-24c10da2b47372c20784bc4d0e07015c78ab33da4428ef677fa4926b9928e49d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical materials</topic><topic>Bone density</topic><topic>Bone implants</topic><topic>Bone mineral density</topic><topic>Bone remodeling</topic><topic>Bone turnover</topic><topic>Clinical trials</topic><topic>Coating</topic><topic>Coatings</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Emission analysis</topic><topic>Evaluation</topic><topic>Fluorides</topic><topic>Fluorine isotopes</topic><topic>Hip</topic><topic>Hydroxyapatite</topic><topic>Joint replacement surgery</topic><topic>Joint surgery</topic><topic>Metabolism</topic><topic>Patient satisfaction</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Prevention</topic><topic>Prostheses</topic><topic>Randomization</topic><topic>Surgery</topic><topic>Surgical implants</topic><topic>Tomography</topic><topic>Total hip arthroplasty</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Inaba, Yutaka</creatorcontrib><creatorcontrib>Miyamae, Yushi</creatorcontrib><creatorcontrib>Oba, Masatoshi</creatorcontrib><creatorcontrib>Hyonmin, Choe</creatorcontrib><creatorcontrib>Kobayashi, Naomi</creatorcontrib><creatorcontrib>Tezuka, Taro</creatorcontrib><creatorcontrib>Morita, Akira</creatorcontrib><collection>الدوريات 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Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial</atitle><jtitle>BioMed research international</jtitle><date>2020-01-01</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Hydroxyapatite- (HA-) coated implants tend to achieve good osteoinductivity and stable clinical results; however, the influence of the coating on the prevention of bone mineral density (BMD) loss around the implant is unclear. The purpose of this randomized controlled trial was to evaluate the effectiveness of HA-coated implants for preventing BMD loss and to determine the status of bone remodeling after total hip arthroplasty (THA), making comparisons with non-HA-coated implants. Methods. A total of 52 patients who underwent primary THA were randomly allocated to HA and non-HA groups. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at 1 week postoperation to form a baseline measurement, and then 24 weeks and 48 weeks after surgery. The relative change in BMD was evaluated for regions of interest (ROIs) based on the Gruen zone classifications. 18F-fluoride positron emission tomography (PET) was performed at 24 weeks postsurgery, and the maximum standardized uptake values (SUVmax) were evaluated in the proximal (HA-coated) and distal (non-HA-coated) areas in both groups. Results. There were significant differences in BMD loss in ROIs 3 and 6 (p=0.03), while no significant difference was observed in ROI 7 at either 24 or 48 weeks postsurgery. There was no significant correlation between PET uptake and BMD (24 or 48 weeks) in either group. Conclusion. The influence of a HA coating in terms of BMD preservation is limited. No significant correlation was found between BMD and SUVmax measured by PET, either with or without the use of a HA coating.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32185203</pmid><doi>10.1155/2020/4154290</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-2419-0860</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Biomedical materials Bone density Bone implants Bone mineral density Bone remodeling Bone turnover Clinical trials Coating Coatings Dual energy X-ray absorptiometry Emission analysis Evaluation Fluorides Fluorine isotopes Hip Hydroxyapatite Joint replacement surgery Joint surgery Metabolism Patient satisfaction Positron emission Positron emission tomography Prevention Prostheses Randomization Surgery Surgical implants Tomography Total hip arthroplasty Transplants & implants |
| title | Influence of Hydroxyapatite Coating for the Prevention of Bone Mineral Density Loss and Bone Metabolism after Total Hip Arthroplasty: Assessment Using 18F-Fluoride Positron Emission Tomography and Dual-Energy X-Ray Absorptiometry by Randomized Controlled Trial |
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