Proteomic Analysis Reveals Novel Mechanisms by Which Polychlorinated Biphenyls Compromise the Liver Promoting Diet-Induced Steatohepatitis

Environmental pollution contributes to fatty liver disease pathogenesis. Polychlorinated biphenyl (PCB) exposures have been associated with liver enzyme elevation and suspected steatohepatitis in cohort studies. Male mice treated with the commercial PCB mixture, Aroclor 1260 (20 mg/kg), and fed high...

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Veröffentlicht in:	Journal of proteome research 2019-04, Vol.18 (4), p.1582-1594
Hauptverfasser:	Hardesty, Josiah E, Wahlang, Banrida, Falkner, K. Cameron, Shi, Hongxue, Jin, Jian, Zhou, Yun, Wilkey, Daniel W, Merchant, Michael L, Watson, Corey T, Feng, Wenke, Morris, Andrew J, Hennig, Bernhard, Prough, Russell A, Cave, Matthew C
Format:	Artikel
Sprache:	eng
Schlagworte:	albumins aroclors chronic exposure cohort studies cytoskeleton epidermal growth factor factor analysis fatty liver fibrosis gene activation glutathione high fat diet humans liver males malnutrition mechanism of action metabolism mice pathogenesis phosphorylation pollutants pollution protein content proteome proteomics receptors transcription factors transforming growth factor beta
Online-Zugang:	Volltext
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