Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

Senescent cells accumulate with age in vertebrates and promote aging largely through their senescence‐associated secretory phenotype (SASP). Many types of stress induce senescence, including genotoxic stress. ERCC1‐XPF is a DNA repair endonuclease required for multiple DNA repair mechanisms that pro...

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Veröffentlicht in:	Aging cell 2020-03, Vol.19 (3), p.e13094-n/a
Hauptverfasser:	Yousefzadeh, Matthew J., Zhao, Jing, Bukata, Christina, Wade, Erin A., McGowan, Sara J., Angelini, Luise A., Bank, Michael P., Gurkar, Aditi U., McGuckian, Collin A., Calubag, Mariah F., Kato, Jonathan I., Burd, Christin E., Robbins, Paul D., Niedernhofer, Laura J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - metabolism Animals Bioluminescence cellular senescence Cellular Senescence - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - metabolism Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Deoxyribonucleic acid DNA DNA damage DNA Damage - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics endogenous DNA damage Endonuclease Endonucleases - deficiency Endonucleases - genetics ERCC1 protein ERCC1‐XPF Female Gene expression Genomes Genotoxicity GTP-binding protein INK4a protein Lung - metabolism Lymphocytes Male Mice Mice, Inbred C57BL Mice, Transgenic mRNA Mutants Organ Specificity Original p16 Protein Pancreas Pancreas - metabolism Phenotypes progeria RNA, Messenger - genetics Senescence Sex Factors T-Lymphocytes - metabolism Thymus Gland - metabolism β-Galactosidase
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