Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study
Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, base...
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| Veröffentlicht in: | European journal of epidemiology 2020-01, Vol.35 (1), p.75-86 |
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| creator | Xia, Congying Rook, Mieneke Pelgrim, Gert Jan Sidorenkov, Grigory Wisselink, Hendrik J. van Bolhuis, Jurjen N. van Ooijen, Peter M. A. Guo, Jiapan Oudkerk, Matthijs Groen, Harry van den Berge, Maarten van der Harst, Pim Dijkstra, Hildebrand Vonder, Marleen Heuvelmans, Marjolein A. Dorrius, Monique D. De Deyn, Peter Paul de Bock, Geertruida H. Dotinga, Aafje Vliegenthart, Rozemarijn |
| description | Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, based on pulmonary density and bronchial wall thickness, and of CAD, based on the coronary artery calcium score (CACS), at low radiation dose. To determine cut-off values for positive tests for elevated risk and presence of disease is one of the major tasks before considering implementation of CT screening in a general population. The ImaLife (Imaging in Lifelines) study, embedded in the Lifelines study, is designed to establish the reference values of the imaging biomarkers for the big three diseases in a well-defined general population aged 45 years and older. In total, 12,000 participants will undergo CACS and chest acquisitions with latest CT technology. The estimated percentage of individuals with lung nodules needing further workup is around 1–2%. Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. This information can be finally integrated into personalized precision health strategies in the general population. |
| doi_str_mv | 10.1007/s10654-019-00519-0 |
| format | Article |
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A. ; Guo, Jiapan ; Oudkerk, Matthijs ; Groen, Harry ; van den Berge, Maarten ; van der Harst, Pim ; Dijkstra, Hildebrand ; Vonder, Marleen ; Heuvelmans, Marjolein A. ; Dorrius, Monique D. ; De Deyn, Peter Paul ; de Bock, Geertruida H. ; Dotinga, Aafje ; Vliegenthart, Rozemarijn</creator><creatorcontrib>Xia, Congying ; Rook, Mieneke ; Pelgrim, Gert Jan ; Sidorenkov, Grigory ; Wisselink, Hendrik J. ; van Bolhuis, Jurjen N. ; van Ooijen, Peter M. A. ; Guo, Jiapan ; Oudkerk, Matthijs ; Groen, Harry ; van den Berge, Maarten ; van der Harst, Pim ; Dijkstra, Hildebrand ; Vonder, Marleen ; Heuvelmans, Marjolein A. ; Dorrius, Monique D. ; De Deyn, Peter Paul ; de Bock, Geertruida H. ; Dotinga, Aafje ; Vliegenthart, Rozemarijn</creatorcontrib><description>Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, based on pulmonary density and bronchial wall thickness, and of CAD, based on the coronary artery calcium score (CACS), at low radiation dose. To determine cut-off values for positive tests for elevated risk and presence of disease is one of the major tasks before considering implementation of CT screening in a general population. The ImaLife (Imaging in Lifelines) study, embedded in the Lifelines study, is designed to establish the reference values of the imaging biomarkers for the big three diseases in a well-defined general population aged 45 years and older. In total, 12,000 participants will undergo CACS and chest acquisitions with latest CT technology. The estimated percentage of individuals with lung nodules needing further workup is around 1–2%. Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. This information can be finally integrated into personalized precision health strategies in the general population.</description><identifier>ISSN: 0393-2990</identifier><identifier>EISSN: 1573-7284</identifier><identifier>DOI: 10.1007/s10654-019-00519-0</identifier><identifier>PMID: 31016436</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Arteriosclerosis ; Biomarkers ; Calcification (ectopic) ; Calcium ; Cancer ; Cardiology ; Cardiovascular disease ; Cardiovascular system ; Chronic obstructive pulmonary disease ; Computed tomography ; Coronary artery ; Coronary artery disease ; Coronary Artery Disease - diagnostic imaging ; Coronary vessels ; Early Detection of Cancer ; Epidemiology ; Female ; Heart diseases ; Humans ; Infectious Diseases ; Lung - diagnostic imaging ; Lung cancer ; Lung diseases ; Lung Neoplasms - diagnostic imaging ; Lung nodules ; Male ; Mass Screening ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; New Study ; Nodules ; Obstructive lung disease ; Oncology ; Population ; Population Surveillance ; Predictive Value of Tests ; Public Health ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Radiation dosage ; State of the art ; Tomography, X-Ray Computed - methods ; Wall thickness</subject><ispartof>European journal of epidemiology, 2020-01, Vol.35 (1), p.75-86</ispartof><rights>The Author(s) 2019</rights><rights>European Journal of Epidemiology is a copyright of Springer, (2019). All Rights Reserved. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). 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A.</creatorcontrib><creatorcontrib>Guo, Jiapan</creatorcontrib><creatorcontrib>Oudkerk, Matthijs</creatorcontrib><creatorcontrib>Groen, Harry</creatorcontrib><creatorcontrib>van den Berge, Maarten</creatorcontrib><creatorcontrib>van der Harst, Pim</creatorcontrib><creatorcontrib>Dijkstra, Hildebrand</creatorcontrib><creatorcontrib>Vonder, Marleen</creatorcontrib><creatorcontrib>Heuvelmans, Marjolein A.</creatorcontrib><creatorcontrib>Dorrius, Monique D.</creatorcontrib><creatorcontrib>De Deyn, Peter Paul</creatorcontrib><creatorcontrib>de Bock, Geertruida H.</creatorcontrib><creatorcontrib>Dotinga, Aafje</creatorcontrib><creatorcontrib>Vliegenthart, Rozemarijn</creatorcontrib><title>Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study</title><title>European journal of epidemiology</title><addtitle>Eur J Epidemiol</addtitle><addtitle>Eur J Epidemiol</addtitle><description>Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. 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Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. 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State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, based on pulmonary density and bronchial wall thickness, and of CAD, based on the coronary artery calcium score (CACS), at low radiation dose. To determine cut-off values for positive tests for elevated risk and presence of disease is one of the major tasks before considering implementation of CT screening in a general population. The ImaLife (Imaging in Lifelines) study, embedded in the Lifelines study, is designed to establish the reference values of the imaging biomarkers for the big three diseases in a well-defined general population aged 45 years and older. In total, 12,000 participants will undergo CACS and chest acquisitions with latest CT technology. The estimated percentage of individuals with lung nodules needing further workup is around 1–2%. Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. This information can be finally integrated into personalized precision health strategies in the general population.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>31016436</pmid><doi>10.1007/s10654-019-00519-0</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7262-3376</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0393-2990 |
| ispartof | European journal of epidemiology, 2020-01, Vol.35 (1), p.75-86 |
| issn | 0393-2990 1573-7284 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7058676 |
| source | Jstor Complete Legacy; MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Aged, 80 and over Aging Arteriosclerosis Biomarkers Calcification (ectopic) Calcium Cancer Cardiology Cardiovascular disease Cardiovascular system Chronic obstructive pulmonary disease Computed tomography Coronary artery Coronary artery disease Coronary Artery Disease - diagnostic imaging Coronary vessels Early Detection of Cancer Epidemiology Female Heart diseases Humans Infectious Diseases Lung - diagnostic imaging Lung cancer Lung diseases Lung Neoplasms - diagnostic imaging Lung nodules Male Mass Screening Medical imaging Medicine Medicine & Public Health Middle Aged New Study Nodules Obstructive lung disease Oncology Population Population Surveillance Predictive Value of Tests Public Health Pulmonary Disease, Chronic Obstructive - diagnostic imaging Radiation dosage State of the art Tomography, X-Ray Computed - methods Wall thickness |
| title | Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T09%3A33%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Early%20imaging%20biomarkers%20of%20lung%20cancer,%20COPD%20and%20coronary%20artery%20disease%20in%20the%20general%20population:%20rationale%20and%20design%20of%20the%20ImaLife%20(Imaging%20in%20Lifelines)%20Study&rft.jtitle=European%20journal%20of%20epidemiology&rft.au=Xia,%20Congying&rft.date=2020-01-01&rft.volume=35&rft.issue=1&rft.spage=75&rft.epage=86&rft.pages=75-86&rft.issn=0393-2990&rft.eissn=1573-7284&rft_id=info:doi/10.1007/s10654-019-00519-0&rft_dat=%3Cproquest_pubme%3E2213934683%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2212982928&rft_id=info:pmid/31016436&rfr_iscdi=true |