Early-life inhalant allergen exposure, filaggrin genotype, and the development of sensitization from infancy to adolescence

We hypothesized that filaggrin (FLG) loss-of-function mutations modify the effect of allergen exposure on the development of allergic sensitization. We sought to determine whether early-life exposure to inhalant allergens increases the risk of specific sensitization and whether FLG mutations modulat...

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