Anti-inflammatory effects of ozenoxacin, a topical quinolone antimicrobial agent

Ozenoxacin is a topical quinolone showing potent antimicrobial activities against Gram-negative and Gram-positive bacteria and is widely used for the treatment of inflammatory acne. However, the anti-inflammatory activities of ozenoxacin have not been examined so far. In the present study, we invest...

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Veröffentlicht in:	Journal of antibiotics 2020-04, Vol.73 (4), p.247-254
Hauptverfasser:	Tabara, Keisuke, Tamura, Rie, Nakamura, Aki, Mori, Sachi, Kitano, Takamichi, Fujikawa, Koki, Fujikawa, Mika, Okamoto, Kazuaki, Kanayama, Shoji, Uratsuji, Hideya, Ikeda, Fumiaki, Matsumoto, Tatsumi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 631/250/256 692/699/249/2510 82/80 96/95 Acne Acne Vulgaris - drug therapy Acne Vulgaris - pathology Aminopyridines - administration & dosage Aminopyridines - pharmacology Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Antimicrobial agents Bacteria Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line Disease Models, Animal Dose-Response Relationship, Drug Gram-positive bacteria Humans Inflammation - drug therapy Inflammation - microbiology Inflammation - pathology Interleukin-6 - metabolism Interleukin-8 - metabolism Kinases Life Sciences Male Medicinal Chemistry Microbiology Organic Chemistry Phosphorylation Propionibacterium acnes - pathogenicity Quinolones - administration & dosage Quinolones - pharmacology Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha - metabolism
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