B cell-Derived IL35 Drives STAT3-Dependent CD8 + T-cell Exclusion in Pancreatic Cancer

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by a paucity of tumor-proximal CD8 T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8 T-cell exclusion and resistance to immunotherapy are not well-known. Here, using...

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Veröffentlicht in:	Cancer immunology research 2020-03, Vol.8 (3), p.292-308
Hauptverfasser:	Mirlekar, Bhalchandra, Michaud, Daniel, Lee, Samuel J, Kren, Nancy P, Harris, Cameron, Greene, Kevin, Goldman, Emily C, Gupta, Gaorav P, Fields, Ryan C, Hawkins, William G, DeNardo, David G, Rashid, Naim U, Yeh, Jen Jen, McRee, Autumn J, Vincent, Benjamin G, Vignali, Dario A A, Pylayeva-Gupta, Yuliya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - immunology B-Lymphocytes - immunology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - immunology Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - therapy Case-Control Studies CD8-Positive T-Lymphocytes - immunology Cell Proliferation - physiology Humans Immunotherapy, Adoptive - methods Interleukins - genetics Interleukins - immunology Lymphocyte Activation Lymphocytes, Tumor-Infiltrating - immunology Mice Mice, Inbred C57BL Pancreatic Neoplasms - genetics Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Receptors, CCR5 - genetics Receptors, CCR5 - immunology Receptors, CXCR3 - genetics Receptors, CXCR3 - immunology Signal Transduction - immunology STAT3 Transcription Factor - genetics STAT3 Transcription Factor - immunology T-Lymphocytes, Regulatory - immunology Tumor Cells, Cultured Xenograft Model Antitumor Assays
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