Pharmacological basis and new insights of resveratrol action in the cardiovascular system
Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative,...
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| Veröffentlicht in: | British journal of pharmacology 2020-03, Vol.177 (6), p.1258-1277 |
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| creator | Cheng, Chak Kwong Luo, Jiang‐Yun Lau, Chi Wai Chen, Zhen‐Yu Tian, Xiao Yu Huang, Yu |
| description | Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.
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This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc |
| doi_str_mv | 10.1111/bph.14801 |
| format | Article |
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Linked Articles
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Linked Articles
This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc</description><subject>Aging</subject><subject>Anti-Inflammatory Agents</subject><subject>Antioxidants</subject><subject>Arteriosclerosis</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular System</subject><subject>Circadian rhythms</subject><subject>Developmental stages</subject><subject>Dietary Supplements</subject><subject>Energy metabolism</subject><subject>Functional foods & nutraceuticals</subject><subject>Inflammation</subject><subject>Ischemia</subject><subject>Microbiota</subject><subject>Phytoalexins</subject><subject>Resveratrol</subject><subject>Resveratrol - pharmacology</subject><subject>Review</subject><subject>Themed Section: Review</subject><subject>Wine</subject><issn>0007-1188</issn><issn>1476-5381</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhi0EokvhwAsgS1zgkNYT23FyQYIKKFIleoADJ2vsOBtXTrzYyVb79hi2VIDEXObwf_o0o5-Q58DOoMy52Y1nIFoGD8gGhGoqyVt4SDaMMVUBtO0JeZLzDWMlVPIxOeHAhQKpNuTb9YhpQhtD3HqLgRrMPlOcezq7W-rn7LfjkmkcaHJ57xIuKQaKdvFxLjFdRkctpt7HPWa7Bkw0H_Lipqfk0YAhu2d3-5R8_fD-y8VldfX546eLt1eVFYJD1UlgCszA-5qBQeGgha5xChX0baskF0OHdTMYNBxZz1jT1MqBMX0LDSDyU_Lm6N2tZnK9dfOSMOhd8hOmg47o9d_J7Ee9jXutmGyEqovg1Z0gxe-ry4uefLYuBJxdXLOu60YqybpOFfTlP-hNXNNc3tM1V0wJxkEW6vWRsinmnNxwfwww_bMwXQrTvwor7Is_r78nfzdUgPMjcOuDO_zfpN9dXx6VPwA8eaBt</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Cheng, Chak Kwong</creator><creator>Luo, Jiang‐Yun</creator><creator>Lau, Chi Wai</creator><creator>Chen, Zhen‐Yu</creator><creator>Tian, Xiao Yu</creator><creator>Huang, Yu</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1277-6784</orcidid></search><sort><creationdate>202003</creationdate><title>Pharmacological basis and new insights of resveratrol action in the cardiovascular system</title><author>Cheng, Chak Kwong ; Luo, Jiang‐Yun ; Lau, Chi Wai ; Chen, Zhen‐Yu ; Tian, Xiao Yu ; Huang, Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-951071bf3d201ba4e18196e7a71d887534f9a26fbab3a0d006627e1bbd8161aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aging</topic><topic>Anti-Inflammatory Agents</topic><topic>Antioxidants</topic><topic>Arteriosclerosis</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular System</topic><topic>Circadian rhythms</topic><topic>Developmental stages</topic><topic>Dietary Supplements</topic><topic>Energy metabolism</topic><topic>Functional foods & nutraceuticals</topic><topic>Inflammation</topic><topic>Ischemia</topic><topic>Microbiota</topic><topic>Phytoalexins</topic><topic>Resveratrol</topic><topic>Resveratrol - pharmacology</topic><topic>Review</topic><topic>Themed Section: Review</topic><topic>Wine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Chak Kwong</creatorcontrib><creatorcontrib>Luo, Jiang‐Yun</creatorcontrib><creatorcontrib>Lau, Chi Wai</creatorcontrib><creatorcontrib>Chen, Zhen‐Yu</creatorcontrib><creatorcontrib>Tian, Xiao Yu</creatorcontrib><creatorcontrib>Huang, Yu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Chak Kwong</au><au>Luo, Jiang‐Yun</au><au>Lau, Chi Wai</au><au>Chen, Zhen‐Yu</au><au>Tian, Xiao Yu</au><au>Huang, Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacological basis and new insights of resveratrol action in the cardiovascular system</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2020-03</date><risdate>2020</risdate><volume>177</volume><issue>6</issue><spage>1258</spage><epage>1277</epage><pages>1258-1277</pages><issn>0007-1188</issn><issn>1476-5381</issn><eissn>1476-5381</eissn><abstract>Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. 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Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development.
Linked Articles
This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>31347157</pmid><doi>10.1111/bph.14801</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-1277-6784</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Anti-Inflammatory Agents Antioxidants Arteriosclerosis Cardiomyopathy Cardiovascular diseases Cardiovascular System Circadian rhythms Developmental stages Dietary Supplements Energy metabolism Functional foods & nutraceuticals Inflammation Ischemia Microbiota Phytoalexins Resveratrol Resveratrol - pharmacology Review Themed Section: Review Wine |
| title | Pharmacological basis and new insights of resveratrol action in the cardiovascular system |
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