Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses

Flaviviridae infections represent a major global health burden. By deciphering mechanistic aspects of hepatitis C virus (HCV)-host interactions, one could discover common strategy for inhibiting the replication of related flaviviruses. By elucidating the HCV interactome, we identified the 17-beta-hy...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.4040, Article 4040
Hauptverfasser:	Mohamed, Bassim, Mazeaud, Clément, Baril, Martin, Poirier, Donald, Sow, Aïssatou Aïcha, Chatel-Chaix, Laurent, Titorenko, Vladimir, Lamarre, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/89 14/19 17-Hydroxysteroid Dehydrogenases 17-Hydroxysteroid Dehydrogenases - genetics 17-Hydroxysteroid Dehydrogenases - metabolism 631/326 631/326/596/1905 Animals Chlorocebus aethiops Dehydrogenase Dehydrogenases Dengue fever Fatty acids Flaviviridae Global health HeLa Cells Hep G2 Cells Hepacivirus Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C - enzymology Hepatitis C - genetics Humanities and Social Sciences Humans Life cycles Life Sciences multidisciplinary Oleic Acid Oleic Acid - pharmacology Replication Ribonucleic acid RNA Science Science (multidisciplinary) Supplements Vector-borne diseases Vero Cells Virions Virus Replication Virus Replication - drug effects Virus Replication - genetics
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