The Antiosteoporosis Effects of Yishen Bugu Ye Based on Its Regulation on the Differentiation of Osteoblast and Osteoclast

Yishen Bugu Ye (YSBGY), a traditional Chinese medicine comprising 12 types of medicinal herbs, is often prescribed in China to increase bone strength. In this study, the antiosteoporotic effects of YSBGY were investigated in C57BL/6 mice afflicted with dexamethasone- (Dex-) induced osteoporosis (OP)...

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Veröffentlicht in:	BioMed research international 2020, Vol.2020 (2020), p.1-12
Hauptverfasser:	Hu, Min, Huang, Tao, Li, Yutong, Meng, Weiqi, Zhang, Yongfeng, Li, Yangyang, Wang, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Animals Biomedical materials Bone Density Bone growth Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - metabolism Bone Morphogenetic Protein Receptors, Type II - metabolism Bone morphogenetic proteins Bone strength Bones Cancellous Bone Catalase Cell Differentiation - drug effects Chondrocytes Collagen Collagen (type I) Collagen Type I - metabolism Core Binding Factor Alpha 1 Subunit - metabolism Cortical bone Cortical Bone - metabolism Cortical Bone - pathology Cytokines - metabolism Denosumab Density Dexamethasone Differentiation Disease Models, Animal Drugs, Chinese Herbal - pharmacology Edema Femur Fractures Herbal medicine Homeostasis Immunoglobulins Inflammation Interleukin 1 Interleukin 7 Interleukins Kidneys Laboratory animals Liver Lymphocytes Male Medical research Medicinal herbs Medicinal plants Medicine, Botanic Medicine, Herbal Mice Mice, Inbred C57BL NF-AT protein Osteoblastogenesis Osteoblasts - drug effects Osteocalcin Osteocalcin - metabolism Osteoclastogenesis Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis Osteopontin - metabolism Osteoporosis Osteoporosis - diagnostic imaging Osteoporosis - drug therapy Osteoporosis - pathology Peptides Phosphatase Phosphatases Proteins Spleen Superoxide dismutase Superoxide Dismutase - blood T cells Tartrate-Resistant Acid Phosphatase - metabolism Tibia Traditional Chinese medicine Transcription factors Tumor necrosis factor-TNF Variance analysis
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