Scorpion alleviates bone cancer pain through inhibition of bone destruction and glia activation

Background Bone cancer pain is common in patients with advanced cancers as tumor metastasizes to bone. The inefficient clinical treatment severely reduces quality of life of bone cancer pain patients. During the pain status, activated spinal astrocytes and microglia release various inflammatory cyto...

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Veröffentlicht in:	Molecular pain 2020, Vol.16, p.1744806920909993-1744806920909993
Hauptverfasser:	Yu, Jiachuan, Luo, Yuanyuan, Jin, Huidan, Lv, Jiaxin, Zhou, Tingting, Yabasin, Iddrisu Baba, Wen, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Astrocytes Astrocytes - metabolism Behavior, Animal Biological Products - therapeutic use Bone and Bones - pathology Bone cancer Bone Neoplasms - drug therapy Bone Neoplasms - physiopathology Bone tumors Cancer Pain - drug therapy Cancer Pain - physiopathology Cell Line, Tumor Cell proliferation Female Filaments Glial fibrillary acidic protein Hyperalgesia IL-1β Immunofluorescence Inflammation Interleukin 6 Interleukin-1beta - metabolism Interleukin-6 - metabolism Mammary Neoplasms, Animal - pathology Microglia mRNA Neoplasm Transplantation Neuroglia - drug effects Neuroglia - metabolism Pain Pain perception Patients Proteins Quality of life Rats Rats, Sprague-Dawley Scorpions - chemistry Spinal cord Spinal Cord - metabolism Spinal Cord - pathology Stomach Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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