ABCA12 regulates insulin secretion from β‐cells

Dysregulation of lipid homeostasis is intimately associated with defects in insulin secretion, a key feature of type 2 diabetes. Here, we explore the role of the putative lipid transporter ABCA12 in regulating insulin secretion from β‐cells. Mice with β‐cell‐specific deletion of Abca12 display impai...

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Veröffentlicht in:	EMBO reports 2020-03, Vol.21 (3), p.e48692-n/a
Hauptverfasser:	Ursino, Gloria M, Fu, Ying, Cottle, Denny L, Mukhamedova, Nigora, Jones, Lynelle K, Low, Hann, Tham, Ming Shen, Gan, Wan Jun, Mellett, Natalie A, Das, Partha P, Weir, Jacquelyn M, Ditiatkovski, Michael, Fynch, Stacey, Thorn, Peter, Thomas, Helen E, Meikle, Peter J, Parkington, Helena C, Smyth, Ian M, Sviridov, Dmitri
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCA1 protein ABCA12 Actin Animals Apoptosis ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism ATP-Binding Cassette Transporters - metabolism ATP-binding protein Beta cells Cdc42 protein Cell death Cell membranes Ceramide Cholesterol cholesterol homeostasis Clonal deletion Cytology Cytoskeleton Defects Deletion Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism EMBO20 EMBO21 Glucose Glucose - metabolism Granular materials Guanosine triphosphatases Homeostasis Insulin Insulin - metabolism Insulin Secretion Insulin-Secreting Cells - metabolism Lipid rafts Lipids Mice Morphology Pancreas Polymerization Potassium Protein transport Proteins Rafts Secretion Secretory vesicles type 2 diabetes
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