Identification of a combination of transcription factors that synergistically increases endothelial cell barrier resistance

Endothelial cells (ECs) display remarkable plasticity during development before becoming quiescent and functionally mature. EC maturation is directed by several known transcription factors (TFs), but the specific set of TFs responsible for promoting high-resistance barriers, such as the blood-brain...

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Veröffentlicht in:	Scientific reports 2020-03, Vol.10 (1), p.3886-3886, Article 3886
Hauptverfasser:	Roudnicky, Filip, Kim, Bo Kyoung, Lan, Yanjun, Schmucki, Roland, Küppers, Verena, Christensen, Klaus, Graf, Martin, Patsch, Christoph, Burcin, Mark, Meyer, Claas Aiko, Westenskow, Peter D., Cowan, Chad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/106 38 38/90 38/91 42 42/44 631/136/16/1986 631/532/1360 Blood-brain barrier Blood-Brain Barrier - cytology Cell Differentiation Central nervous system Developmental plasticity Dextran Endothelial cells Endothelial Cells - cytology Endothelial Cells - metabolism Ets-1 protein Gene expression Humanities and Social Sciences Humans Maturation multidisciplinary Permeability Pluripotency Pluripotent Stem Cells - cytology Protein transport Science Science (multidisciplinary) Stem cells Tight junctions Transcription factors Transcription Factors - metabolism Wnt protein
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