SRV2 promotes mitochondrial fission and Mst1-Drp1 signaling in LPS-induced septic cardiomyopathy

Mitochondrial fission is associated with cardiomyocyte death and myocardial depression, and suppressor of ras val-2 (SRV2) is a newly discovered pro-fission protein. In this study, we examined the mechanisms of SRV2-mediated mitochondrial fission in septic cardiomyopathy. Western blotting, ELISA, an...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2020-01, Vol.12 (2), p.1417-1432
Hauptverfasser:	Shang, Xiuling, Zhang, Yingrui, Xu, Jingqing, Li, Min, Wang, Xiaoting, Yu, Rongguo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiomyopathies - etiology Cardiomyopathies - metabolism Cardiomyopathies - pathology Cell Survival - genetics Death-Associated Protein Kinases - metabolism Disease Models, Animal Hepatocyte Growth Factor - metabolism Lipopolysaccharides - adverse effects Mice Mitochondria - genetics Mitochondria - metabolism Mitochondrial Dynamics - genetics Mitochondrial Proteins - genetics Myocytes, Cardiac - metabolism Proto-Oncogene Proteins - metabolism Research Paper
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