Axl-148b chimeric aptamers inhibit breast cancer and melanoma progression

microRNAs (miRNAs) are small non-coding RNAs acting as negative regulators of gene expression and involved in tumor progression. We recently showed that inhibition of the pro-metastatic miR-214 and simultaneous overexpression of its downstream player, the anti-metastatic miR-148b, strongly reduced m...

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Veröffentlicht in:	International journal of biological sciences 2020-01, Vol.16 (7), p.1238-1251
Hauptverfasser:	Quirico, Lorena, Orso, Francesca, Esposito, Carla L, Bertone, Sofia, Coppo, Roberto, Conti, Laura, Catuogno, Silvia, Cavallo, Federica, de Franciscis, Vittorio, Taverna, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Annealing Antibodies Apoptosis Aptamers Axl protein Biotechnology Breast cancer Cancer Conjugates Gene expression Kinases Laboratories Melanoma Metastases Metastasis MicroRNAs miRNA Necrosis Non-coding RNA Protein-tyrosine kinase receptors Regulators Research Paper Selectivity Tumor cells Tumors Tyrosine Xenografts Xenotransplantation
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