Oligopeptide-modified poly(beta-amino ester)s-coated AdNuPARmE1A: Boosting the efficacy of intravenously administered therapeutic adenoviruses

Oncolytic adenoviruses are used as agents for the treatment of cancer. However, their potential is limited due to the high seroprevalence of anti-adenovirus neutralizing antibodies (nAbs) within the population and the rapid liver sequestration when systemically administered. To overcome these challe...

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Veröffentlicht in:	Theranostics 2020-01, Vol.10 (6), p.2744-2758
Hauptverfasser:	Brugada-Vilà, Pau, Cascante, Anna, Lázaro, Miguel Ángel, Castells-Sala, Cristina, Fornaguera, Cristina, Rovira-Rigau, Maria, Albertazzi, Lorenzo, Borros, Salvador, Fillat, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses Animals Antibodies Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Binding sites Cancer Cell Line, Tumor Efficiency HEK293 Cells Humans Mice Mice, Inbred C57BL Microscopy Nanoparticles Neoplasms - therapy Oligopeptides - chemistry Oligopeptides - pharmacokinetics Oligopeptides - pharmacology Oncolytic Virotherapy - methods Oncolytic Viruses Pancreatic cancer Physiology Polyethylene glycol Polymers Polymers - chemistry Polymers - pharmacokinetics Polymers - pharmacology RAW 264.7 Cells Research Paper
Online-Zugang:	Volltext
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