Skeletal muscle transcriptional networks linked to type I myofiber grouping in Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative disorder impacting cognition, movement, and quality of life in >10 million individuals worldwide. We recently characterized and quantified a skeletal muscle pathology in PD represented by exaggerated type I myofiber grouping presumed to...

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Veröffentlicht in:	Journal of applied physiology (1985) 2020-02, Vol.128 (2), p.229-240
Hauptverfasser:	Lavin, Kaleen M, Sealfon, Stuart C, McDonald, Merry-Lynn N, Roberts, Brandon M, Wilk, Katarzyna, Nair, Venugopalan D, Ge, Yongchao, Lakshman Kumar, Preeti, Windham, Samuel T, Bamman, Marcas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Aged Annotations Cell cycle Cell survival Cognition Correlation analysis Denervation Energy metabolism Female Gene expression Gene Regulatory Networks Genes Group size Humans Male Mapping Men miRNA Movement disorders Muscle Fibers, Slow-Twitch - pathology Muscle, Skeletal - pathology Muscles Musculoskeletal system Network analysis Networks Neurodegenerative diseases Neuromuscular Junction - physiopathology Older people Parkinson Disease - genetics Parkinson Disease - pathology Parkinson's disease Phenotypes Polyadenine Post-transcription Protein turnover Quality of Life Reinnervation RNA-Seq Sex Signaling Skeletal muscle Survival Transcriptome Transcriptomics Young adults
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